BindingDB PrimarySearch

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SMILES: COc1cc2ncnc(Nc3cccc(Cl)c3F)c2cc1CN1CCN(C)CC1C(N)=O

InChI Key: InChIKey=WKIVNYVECBOILW-UHFFFAOYSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 13 hits for monomerid = 50183839
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
cAMP-dependent protein kinase catalytic subunit alpha/beta/gamma (Homo sapiens (Human))	BDBM50183839 (1-((4-(3-chloro-2-fluorophenylamino)-7-methoxyquin...) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Centre de Recherches Curated by ChEMBL					Assay Description Inhibition of PKA				Bioorg Med Chem Lett 16: 2672-6 (2006) Article DOI: 10.1016/j.bmcl.2006.02.025 BindingDB Entry DOI: 10.7270/Q25H7FVK
Centre de Recherches Curated by ChEMBL					More data for this Ligand-Target Pair
Epidermal growth factor receptor (Homo sapiens (Human))	BDBM50183839 (1-((4-(3-chloro-2-fluorophenylamino)-7-methoxyquin...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	30	n/a	n/a	n/a	n/a	n/a	n/a
Centre de Recherches Curated by ChEMBL					Assay Description Inhibition of EGFR in presence of 2 uM ATP				Bioorg Med Chem Lett 16: 2672-6 (2006) Article DOI: 10.1016/j.bmcl.2006.02.025 BindingDB Entry DOI: 10.7270/Q25H7FVK
Centre de Recherches Curated by ChEMBL					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 11/12/13/14 (Homo sapiens (Human))	BDBM50183839 (1-((4-(3-chloro-2-fluorophenylamino)-7-methoxyquin...) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Centre de Recherches Curated by ChEMBL					Assay Description Inhibition of SAP kinase				Bioorg Med Chem Lett 16: 2672-6 (2006) Article DOI: 10.1016/j.bmcl.2006.02.025 BindingDB Entry DOI: 10.7270/Q25H7FVK
Centre de Recherches Curated by ChEMBL					More data for this Ligand-Target Pair
Rho-associated protein kinase 2 (Homo sapiens (Human))	BDBM50183839 (1-((4-(3-chloro-2-fluorophenylamino)-7-methoxyquin...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Centre de Recherches Curated by ChEMBL					Assay Description Inhibition of ROCK2				Bioorg Med Chem Lett 16: 2672-6 (2006) Article DOI: 10.1016/j.bmcl.2006.02.025 BindingDB Entry DOI: 10.7270/Q25H7FVK
Centre de Recherches Curated by ChEMBL					More data for this Ligand-Target Pair
Serine/threonine-protein kinase Chk1 (Homo sapiens (Human))	BDBM50183839 (1-((4-(3-chloro-2-fluorophenylamino)-7-methoxyquin...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Centre de Recherches Curated by ChEMBL					Assay Description Inhibition of CHK1				Bioorg Med Chem Lett 16: 2672-6 (2006) Article DOI: 10.1016/j.bmcl.2006.02.025 BindingDB Entry DOI: 10.7270/Q25H7FVK
Centre de Recherches Curated by ChEMBL					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 10/8/9 (Homo sapiens (Human))	BDBM50183839 (1-((4-(3-chloro-2-fluorophenylamino)-7-methoxyquin...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Centre de Recherches Curated by ChEMBL					Assay Description Inhibition of JNK				Bioorg Med Chem Lett 16: 2672-6 (2006) Article DOI: 10.1016/j.bmcl.2006.02.025 BindingDB Entry DOI: 10.7270/Q25H7FVK
Centre de Recherches Curated by ChEMBL					More data for this Ligand-Target Pair
Glycogen synthase kinase-3 beta (Homo sapiens (Human))	BDBM50183839 (1-((4-(3-chloro-2-fluorophenylamino)-7-methoxyquin...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Centre de Recherches Curated by ChEMBL					Assay Description Inhibition of GSK3-beta				Bioorg Med Chem Lett 16: 2672-6 (2006) Article DOI: 10.1016/j.bmcl.2006.02.025 BindingDB Entry DOI: 10.7270/Q25H7FVK
Centre de Recherches Curated by ChEMBL					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src (Homo sapiens (Human))	BDBM50183839 (1-((4-(3-chloro-2-fluorophenylamino)-7-methoxyquin...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Centre de Recherches Curated by ChEMBL					Assay Description Inhibition of Src				Bioorg Med Chem Lett 16: 2672-6 (2006) Article DOI: 10.1016/j.bmcl.2006.02.025 BindingDB Entry DOI: 10.7270/Q25H7FVK
Centre de Recherches Curated by ChEMBL					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM50183839 (1-((4-(3-chloro-2-fluorophenylamino)-7-methoxyquin...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Centre de Recherches Curated by ChEMBL					Assay Description Inhibition of KDR				Bioorg Med Chem Lett 16: 2672-6 (2006) Article DOI: 10.1016/j.bmcl.2006.02.025 BindingDB Entry DOI: 10.7270/Q25H7FVK
Centre de Recherches Curated by ChEMBL					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 1 (Homo sapiens (Human))	BDBM50183839 (1-((4-(3-chloro-2-fluorophenylamino)-7-methoxyquin...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Centre de Recherches Curated by ChEMBL					Assay Description Inhibition of MAPK				Bioorg Med Chem Lett 16: 2672-6 (2006) Article DOI: 10.1016/j.bmcl.2006.02.025 BindingDB Entry DOI: 10.7270/Q25H7FVK
Centre de Recherches Curated by ChEMBL					More data for this Ligand-Target Pair
Epidermal growth factor receptor (Homo sapiens (Human))	BDBM50183839 (1-((4-(3-chloro-2-fluorophenylamino)-7-methoxyquin...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	80	n/a	n/a	n/a	n/a	n/a	n/a
Centre de Recherches Curated by ChEMBL					Assay Description Inhibition of EGFR in presence of 2 uM ATP				Bioorg Med Chem Lett 16: 2672-6 (2006) Article DOI: 10.1016/j.bmcl.2006.02.025 BindingDB Entry DOI: 10.7270/Q25H7FVK
Centre de Recherches Curated by ChEMBL					More data for this Ligand-Target Pair
Serine/threonine-protein kinase Sgk1 (Homo sapiens (Human))	BDBM50183839 (1-((4-(3-chloro-2-fluorophenylamino)-7-methoxyquin...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Centre de Recherches Curated by ChEMBL					Assay Description Inhibition of SGK				Bioorg Med Chem Lett 16: 2672-6 (2006) Article DOI: 10.1016/j.bmcl.2006.02.025 BindingDB Entry DOI: 10.7270/Q25H7FVK
Centre de Recherches Curated by ChEMBL					More data for this Ligand-Target Pair
Tyrosine-protein kinase Lck (Homo sapiens (Human))	BDBM50183839 (1-((4-(3-chloro-2-fluorophenylamino)-7-methoxyquin...) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Centre de Recherches Curated by ChEMBL					Assay Description Inhibition of LCK				Bioorg Med Chem Lett 16: 2672-6 (2006) Article DOI: 10.1016/j.bmcl.2006.02.025 BindingDB Entry DOI: 10.7270/Q25H7FVK
Centre de Recherches Curated by ChEMBL					More data for this Ligand-Target Pair