Found 13 hits for monomerid = 50183860 Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Mitogen-activated protein kinase 10/8/9
(Homo sapiens (Human)) | BDBM50183860
((R)-2-(((4-(3-chloro-2-fluorophenylamino)-7-methox...)Show SMILES COc1cc2ncnc(Nc3cccc(Cl)c3F)c2cc1CN(C)[C@H](C)C(=O)N(C)C Show InChI InChI=1S/C22H25ClFN5O2/c1-13(22(30)28(2)3)29(4)11-14-9-15-18(10-19(14)31-5)25-12-26-21(15)27-17-8-6-7-16(23)20(17)24/h6-10,12-13H,11H2,1-5H3,(H,25,26,27)/t13-/m1/s1 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Centre de Recherches
Curated by ChEMBL
| Assay Description Inhibition of JNK |
Bioorg Med Chem Lett 16: 2672-6 (2006)
Article DOI: 10.1016/j.bmcl.2006.02.025 BindingDB Entry DOI: 10.7270/Q25H7FVK |
More data for this Ligand-Target Pair | |
Serine/threonine-protein kinase Chk1
(Homo sapiens (Human)) | BDBM50183860
((R)-2-(((4-(3-chloro-2-fluorophenylamino)-7-methox...)Show SMILES COc1cc2ncnc(Nc3cccc(Cl)c3F)c2cc1CN(C)[C@H](C)C(=O)N(C)C Show InChI InChI=1S/C22H25ClFN5O2/c1-13(22(30)28(2)3)29(4)11-14-9-15-18(10-19(14)31-5)25-12-26-21(15)27-17-8-6-7-16(23)20(17)24/h6-10,12-13H,11H2,1-5H3,(H,25,26,27)/t13-/m1/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Centre de Recherches
Curated by ChEMBL
| Assay Description Inhibition of CHK1 |
Bioorg Med Chem Lett 16: 2672-6 (2006)
Article DOI: 10.1016/j.bmcl.2006.02.025 BindingDB Entry DOI: 10.7270/Q25H7FVK |
More data for this Ligand-Target Pair | |
Rho-associated protein kinase 2
(Homo sapiens (Human)) | BDBM50183860
((R)-2-(((4-(3-chloro-2-fluorophenylamino)-7-methox...)Show SMILES COc1cc2ncnc(Nc3cccc(Cl)c3F)c2cc1CN(C)[C@H](C)C(=O)N(C)C Show InChI InChI=1S/C22H25ClFN5O2/c1-13(22(30)28(2)3)29(4)11-14-9-15-18(10-19(14)31-5)25-12-26-21(15)27-17-8-6-7-16(23)20(17)24/h6-10,12-13H,11H2,1-5H3,(H,25,26,27)/t13-/m1/s1 | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Centre de Recherches
Curated by ChEMBL
| Assay Description Inhibition of ROCK2 |
Bioorg Med Chem Lett 16: 2672-6 (2006)
Article DOI: 10.1016/j.bmcl.2006.02.025 BindingDB Entry DOI: 10.7270/Q25H7FVK |
More data for this Ligand-Target Pair | |
cAMP-dependent protein kinase catalytic subunit alpha/beta/gamma
(Homo sapiens (Human)) | BDBM50183860
((R)-2-(((4-(3-chloro-2-fluorophenylamino)-7-methox...)Show SMILES COc1cc2ncnc(Nc3cccc(Cl)c3F)c2cc1CN(C)[C@H](C)C(=O)N(C)C Show InChI InChI=1S/C22H25ClFN5O2/c1-13(22(30)28(2)3)29(4)11-14-9-15-18(10-19(14)31-5)25-12-26-21(15)27-17-8-6-7-16(23)20(17)24/h6-10,12-13H,11H2,1-5H3,(H,25,26,27)/t13-/m1/s1 | PDB
KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Centre de Recherches
Curated by ChEMBL
| Assay Description Inhibition of PKA |
Bioorg Med Chem Lett 16: 2672-6 (2006)
Article DOI: 10.1016/j.bmcl.2006.02.025 BindingDB Entry DOI: 10.7270/Q25H7FVK |
More data for this Ligand-Target Pair | |
Epidermal growth factor receptor
(Homo sapiens (Human)) | BDBM50183860
((R)-2-(((4-(3-chloro-2-fluorophenylamino)-7-methox...)Show SMILES COc1cc2ncnc(Nc3cccc(Cl)c3F)c2cc1CN(C)[C@H](C)C(=O)N(C)C Show InChI InChI=1S/C22H25ClFN5O2/c1-13(22(30)28(2)3)29(4)11-14-9-15-18(10-19(14)31-5)25-12-26-21(15)27-17-8-6-7-16(23)20(17)24/h6-10,12-13H,11H2,1-5H3,(H,25,26,27)/t13-/m1/s1 | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 40 | n/a | n/a | n/a | n/a | n/a | n/a |
Centre de Recherches
Curated by ChEMBL
| Assay Description Inhibition of EGFR in presence of 2 uM ATP |
Bioorg Med Chem Lett 16: 2672-6 (2006)
Article DOI: 10.1016/j.bmcl.2006.02.025 BindingDB Entry DOI: 10.7270/Q25H7FVK |
More data for this Ligand-Target Pair | |
Mitogen-activated protein kinase 11/12/13/14
(Homo sapiens (Human)) | BDBM50183860
((R)-2-(((4-(3-chloro-2-fluorophenylamino)-7-methox...)Show SMILES COc1cc2ncnc(Nc3cccc(Cl)c3F)c2cc1CN(C)[C@H](C)C(=O)N(C)C Show InChI InChI=1S/C22H25ClFN5O2/c1-13(22(30)28(2)3)29(4)11-14-9-15-18(10-19(14)31-5)25-12-26-21(15)27-17-8-6-7-16(23)20(17)24/h6-10,12-13H,11H2,1-5H3,(H,25,26,27)/t13-/m1/s1 | PDB
KEGG
UniProtKB/SwissProt
antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Centre de Recherches
Curated by ChEMBL
| Assay Description Inhibition of SAP kinase |
Bioorg Med Chem Lett 16: 2672-6 (2006)
Article DOI: 10.1016/j.bmcl.2006.02.025 BindingDB Entry DOI: 10.7270/Q25H7FVK |
More data for this Ligand-Target Pair | |
Mitogen-activated protein kinase 1
(Homo sapiens (Human)) | BDBM50183860
((R)-2-(((4-(3-chloro-2-fluorophenylamino)-7-methox...)Show SMILES COc1cc2ncnc(Nc3cccc(Cl)c3F)c2cc1CN(C)[C@H](C)C(=O)N(C)C Show InChI InChI=1S/C22H25ClFN5O2/c1-13(22(30)28(2)3)29(4)11-14-9-15-18(10-19(14)31-5)25-12-26-21(15)27-17-8-6-7-16(23)20(17)24/h6-10,12-13H,11H2,1-5H3,(H,25,26,27)/t13-/m1/s1 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Centre de Recherches
Curated by ChEMBL
| Assay Description Inhibition of MAPK |
Bioorg Med Chem Lett 16: 2672-6 (2006)
Article DOI: 10.1016/j.bmcl.2006.02.025 BindingDB Entry DOI: 10.7270/Q25H7FVK |
More data for this Ligand-Target Pair | |
Tyrosine-protein kinase Lck
(Homo sapiens (Human)) | BDBM50183860
((R)-2-(((4-(3-chloro-2-fluorophenylamino)-7-methox...)Show SMILES COc1cc2ncnc(Nc3cccc(Cl)c3F)c2cc1CN(C)[C@H](C)C(=O)N(C)C Show InChI InChI=1S/C22H25ClFN5O2/c1-13(22(30)28(2)3)29(4)11-14-9-15-18(10-19(14)31-5)25-12-26-21(15)27-17-8-6-7-16(23)20(17)24/h6-10,12-13H,11H2,1-5H3,(H,25,26,27)/t13-/m1/s1 | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Centre de Recherches
Curated by ChEMBL
| Assay Description Inhibition of LCK |
Bioorg Med Chem Lett 16: 2672-6 (2006)
Article DOI: 10.1016/j.bmcl.2006.02.025 BindingDB Entry DOI: 10.7270/Q25H7FVK |
More data for this Ligand-Target Pair | |
Serine/threonine-protein kinase Sgk1
(Homo sapiens (Human)) | BDBM50183860
((R)-2-(((4-(3-chloro-2-fluorophenylamino)-7-methox...)Show SMILES COc1cc2ncnc(Nc3cccc(Cl)c3F)c2cc1CN(C)[C@H](C)C(=O)N(C)C Show InChI InChI=1S/C22H25ClFN5O2/c1-13(22(30)28(2)3)29(4)11-14-9-15-18(10-19(14)31-5)25-12-26-21(15)27-17-8-6-7-16(23)20(17)24/h6-10,12-13H,11H2,1-5H3,(H,25,26,27)/t13-/m1/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Centre de Recherches
Curated by ChEMBL
| Assay Description Inhibition of SGK |
Bioorg Med Chem Lett 16: 2672-6 (2006)
Article DOI: 10.1016/j.bmcl.2006.02.025 BindingDB Entry DOI: 10.7270/Q25H7FVK |
More data for this Ligand-Target Pair | |
Glycogen synthase kinase-3 beta
(Homo sapiens (Human)) | BDBM50183860
((R)-2-(((4-(3-chloro-2-fluorophenylamino)-7-methox...)Show SMILES COc1cc2ncnc(Nc3cccc(Cl)c3F)c2cc1CN(C)[C@H](C)C(=O)N(C)C Show InChI InChI=1S/C22H25ClFN5O2/c1-13(22(30)28(2)3)29(4)11-14-9-15-18(10-19(14)31-5)25-12-26-21(15)27-17-8-6-7-16(23)20(17)24/h6-10,12-13H,11H2,1-5H3,(H,25,26,27)/t13-/m1/s1 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Centre de Recherches
Curated by ChEMBL
| Assay Description Inhibition of GSK3-beta |
Bioorg Med Chem Lett 16: 2672-6 (2006)
Article DOI: 10.1016/j.bmcl.2006.02.025 BindingDB Entry DOI: 10.7270/Q25H7FVK |
More data for this Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50183860
((R)-2-(((4-(3-chloro-2-fluorophenylamino)-7-methox...)Show SMILES COc1cc2ncnc(Nc3cccc(Cl)c3F)c2cc1CN(C)[C@H](C)C(=O)N(C)C Show InChI InChI=1S/C22H25ClFN5O2/c1-13(22(30)28(2)3)29(4)11-14-9-15-18(10-19(14)31-5)25-12-26-21(15)27-17-8-6-7-16(23)20(17)24/h6-10,12-13H,11H2,1-5H3,(H,25,26,27)/t13-/m1/s1 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Centre de Recherches
Curated by ChEMBL
| Assay Description Inhibition of KDR |
Bioorg Med Chem Lett 16: 2672-6 (2006)
Article DOI: 10.1016/j.bmcl.2006.02.025 BindingDB Entry DOI: 10.7270/Q25H7FVK |
More data for this Ligand-Target Pair | |
Proto-oncogene tyrosine-protein kinase Src
(Homo sapiens (Human)) | BDBM50183860
((R)-2-(((4-(3-chloro-2-fluorophenylamino)-7-methox...)Show SMILES COc1cc2ncnc(Nc3cccc(Cl)c3F)c2cc1CN(C)[C@H](C)C(=O)N(C)C Show InChI InChI=1S/C22H25ClFN5O2/c1-13(22(30)28(2)3)29(4)11-14-9-15-18(10-19(14)31-5)25-12-26-21(15)27-17-8-6-7-16(23)20(17)24/h6-10,12-13H,11H2,1-5H3,(H,25,26,27)/t13-/m1/s1 | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Centre de Recherches
Curated by ChEMBL
| Assay Description Inhibition of Src |
Bioorg Med Chem Lett 16: 2672-6 (2006)
Article DOI: 10.1016/j.bmcl.2006.02.025 BindingDB Entry DOI: 10.7270/Q25H7FVK |
More data for this Ligand-Target Pair | |
Epidermal growth factor receptor
(Homo sapiens (Human)) | BDBM50183860
((R)-2-(((4-(3-chloro-2-fluorophenylamino)-7-methox...)Show SMILES COc1cc2ncnc(Nc3cccc(Cl)c3F)c2cc1CN(C)[C@H](C)C(=O)N(C)C Show InChI InChI=1S/C22H25ClFN5O2/c1-13(22(30)28(2)3)29(4)11-14-9-15-18(10-19(14)31-5)25-12-26-21(15)27-17-8-6-7-16(23)20(17)24/h6-10,12-13H,11H2,1-5H3,(H,25,26,27)/t13-/m1/s1 | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 90 | n/a | n/a | n/a | n/a | n/a | n/a |
Centre de Recherches
Curated by ChEMBL
| Assay Description Inhibition of EGFR in presence of 2 uM ATP |
Bioorg Med Chem Lett 16: 2672-6 (2006)
Article DOI: 10.1016/j.bmcl.2006.02.025 BindingDB Entry DOI: 10.7270/Q25H7FVK |
More data for this Ligand-Target Pair | |