BDBM50184046 CHEMBL425418::N-(2-(dimethylamino)ethyl)-6-(2-(3,4,5-trimethoxyphenylamino)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)picolinamide

SMILES: COc1cc(Nc2ncc3ccn(-c4cccc(n4)C(=O)NCCN(C)C)c3n2)cc(OC)c1OC

InChI Key: InChIKey=CRKWKHJABOJVAY-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50184046   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Focal adhesion kinase 1 (Homo sapiens (Human))	BDBM50184046 (CHEMBL425418 | N-(2-(dimethylamino)ethyl)-6-(2-(3,...) Show SMILES COc1cc(Nc2ncc3ccn(-c4cccc(n4)C(=O)NCCN(C)C)c3n2)cc(OC)c1OC Show InChI InChI=1S/C25H29N7O4/c1-31(2)12-10-26-24(33)18-7-6-8-21(29-18)32-11-9-16-15-27-25(30-23(16)32)28-17-13-19(34-3)22(36-5)20(14-17)35-4/h6-9,11,13-15H,10,12H2,1-5H3,(H,26,33)(H,27,28,30)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	634	n/a	n/a	n/a	n/a	n/a	n/a
Genomics Institute of the Novartis Research Foundation (GNF) Curated by ChEMBL					Assay Description Inhibition of FAK				Bioorg Med Chem Lett 16: 2689-92 (2006) Article DOI: 10.1016/j.bmcl.2006.02.032 BindingDB Entry DOI: 10.7270/Q2NK3DN0
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