BDBM50184194 3,3'-difluoro-4'-(pyridin-2-ylaminomethyl)-biphenyl-2-carboxylic acid methyl ester::CHEMBL208538

SMILES: COC(=O)c1c(F)cccc1-c1ccc(CNc2ccccn2)c(F)c1

InChI Key: InChIKey=QFANIHXSNQVFLE-UHFFFAOYSA-N

Data: 2 KI

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50184194   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Bradykinin B1 receptor (Homo sapiens (Human))	BDBM50184194 (3,3'-difluoro-4'-(pyridin-2-ylaminomethyl)-bipheny...) Show SMILES COC(=O)c1c(F)cccc1-c1ccc(CNc2ccccn2)c(F)c1 Show InChI InChI=1S/C20H16F2N2O2/c1-26-20(25)19-15(5-4-6-16(19)21)13-8-9-14(17(22)11-13)12-24-18-7-2-3-10-23-18/h2-11H,12H2,1H3,(H,23,24)	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	815	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Heptares Therapeutics Limited Curated by ChEMBL					Assay Description Antagonist activity at human bradykinin B1 receptor expressed in human HEK293 cells assessed as calcium flux by FLIPR assay				J Med Chem 54: 4283-311 (2011) Article DOI: 10.1021/jm200371q BindingDB Entry DOI: 10.7270/Q23N23RZ
					More data for this Ligand-Target Pair
Bradykinin B1 receptor (Homo sapiens (Human))	BDBM50184194 (3,3'-difluoro-4'-(pyridin-2-ylaminomethyl)-bipheny...) Show SMILES COC(=O)c1c(F)cccc1-c1ccc(CNc2ccccn2)c(F)c1 Show InChI InChI=1S/C20H16F2N2O2/c1-26-20(25)19-15(5-4-6-16(19)21)13-8-9-14(17(22)11-13)12-24-18-7-2-3-10-23-18/h2-11H,12H2,1H3,(H,23,24)	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	815	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Binding affinity to human BK1 receptor				Bioorg Med Chem Lett 16: 2791-5 (2006) Article DOI: 10.1016/j.bmcl.2006.01.112 BindingDB Entry DOI: 10.7270/Q28915GX
					More data for this Ligand-Target Pair