null
SMILES: OC(=O)C(=O)CC(=O)c1ccc2n(Cc3ccc(F)cc3)cc(C(=O)CC(=O)C(O)=O)c(=O)c2c1
InChI Key: InChIKey=MMZRUVLLFMTCOG-UHFFFAOYSA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Integrase (Human immunodeficiency virus 1) | BDBM50184349 ((Z)-4-[6-((Z)-3-carboxy-3-hydroxy-acryloyl)-1-(4-f...) | PDB MMDB UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar AffyNet | CHEMBL KEGG PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 17 | n/a | n/a | n/a | n/a | n/a | n/a |
Università di Roma La Sapienza Curated by ChEMBL | Assay Description Inhibition of HIV1 integrase strand transfer activity in presence of MgCl2 by gel-based assay | J Med Chem 49: 1939-45 (2006) Article DOI: 10.1021/jm0511583 BindingDB Entry DOI: 10.7270/Q2GT5MRF | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Integrase (Human immunodeficiency virus 1) | BDBM50184349 ((Z)-4-[6-((Z)-3-carboxy-3-hydroxy-acryloyl)-1-(4-f...) | PDB MMDB UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar AffyNet | CHEMBL KEGG PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 440 | n/a | n/a | n/a | n/a | n/a | n/a |
Università di Roma La Sapienza Curated by ChEMBL | Assay Description Inhibition of HIV1 integrase 3'-processing activity in presence of MgCl2 | J Med Chem 49: 1939-45 (2006) Article DOI: 10.1021/jm0511583 BindingDB Entry DOI: 10.7270/Q2GT5MRF | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Integrase (Human immunodeficiency virus 1) | BDBM50184349 ((Z)-4-[6-((Z)-3-carboxy-3-hydroxy-acryloyl)-1-(4-f...) | PDB MMDB UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar AffyNet | CHEMBL KEGG PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 12 | n/a | n/a | n/a | n/a | n/a | n/a |
Università di Roma La Sapienza Curated by ChEMBL | Assay Description Inhibition of HIV1 integrase strand transfer activity in presence of MnCl2 | J Med Chem 49: 1939-45 (2006) Article DOI: 10.1021/jm0511583 BindingDB Entry DOI: 10.7270/Q2GT5MRF | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Integrase (Human immunodeficiency virus 1) | BDBM50184349 ((Z)-4-[6-((Z)-3-carboxy-3-hydroxy-acryloyl)-1-(4-f...) | PDB UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet | CHEMBL KEGG PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 17 | n/a | n/a | n/a | n/a | n/a | n/a |
Facult£s Universitaires Notre-Dame de la Paix Curated by ChEMBL | Assay Description Inhibition of HIV1 integrase strand transfer activity expressed in Escherichia coli BL21 (DE3) by gel based assay in presence of magnesium | Bioorg Med Chem Lett 19: 4806-9 (2009) Article DOI: 10.1016/j.bmcl.2009.06.044 BindingDB Entry DOI: 10.7270/Q2862K73 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Integrase (Human immunodeficiency virus 1) | BDBM50184349 ((Z)-4-[6-((Z)-3-carboxy-3-hydroxy-acryloyl)-1-(4-f...) | PDB MMDB UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar AffyNet | CHEMBL KEGG PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 200 | n/a | n/a | n/a | n/a | n/a | n/a |
Università di Roma La Sapienza Curated by ChEMBL | Assay Description Inhibition of HIV1 integrase 3'-processing activity in presence of MnCl2 | J Med Chem 49: 1939-45 (2006) Article DOI: 10.1021/jm0511583 BindingDB Entry DOI: 10.7270/Q2GT5MRF | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Integrase (Human immunodeficiency virus 1) | BDBM50184349 ((Z)-4-[6-((Z)-3-carboxy-3-hydroxy-acryloyl)-1-(4-f...) | PDB UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet | CHEMBL KEGG PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 440 | n/a | n/a | n/a | n/a | n/a | n/a |
Facult£s Universitaires Notre-Dame de la Paix Curated by ChEMBL | Assay Description Inhibition of HIV1 integrase 3'-processing activity expressed in Escherichia coli BL21 (DE3) by gel based assay in presence of magnesium | Bioorg Med Chem Lett 19: 4806-9 (2009) Article DOI: 10.1016/j.bmcl.2009.06.044 BindingDB Entry DOI: 10.7270/Q2862K73 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Integrase (Human immunodeficiency virus 1) | BDBM50184349 ((Z)-4-[6-((Z)-3-carboxy-3-hydroxy-acryloyl)-1-(4-f...) | PDB MMDB UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar AffyNet | CHEMBL KEGG PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 16 | n/a | n/a | n/a | n/a | n/a | n/a |
Università di Roma La Sapienza Curated by ChEMBL | Assay Description Inhibition of HIV1 integrase strand transfer activity in presence of MgCl2 by plate-based electrochemiluminescent assay | J Med Chem 49: 1939-45 (2006) Article DOI: 10.1021/jm0511583 BindingDB Entry DOI: 10.7270/Q2GT5MRF | |||||||||||
More data for this Ligand-Target Pair |