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SMILES: COc1nn(cc1Nc1ncc(Cl)c(n1)-c1cnn2ccccc12)C1CCN(CC1)C(C)=O

InChI Key: InChIKey=DGKDQGNOYZSJDK-UHFFFAOYSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50184474   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Insulin-like growth factor 1 receptor (Homo sapiens (Human))	BDBM50184474 (CHEMBL3823522) Show SMILES COc1nn(cc1Nc1ncc(Cl)c(n1)-c1cnn2ccccc12)C1CCN(CC1)C(C)=O Show InChI InChI=1S/C22H23ClN8O2/c1-14(32)29-9-6-15(7-10-29)31-13-18(21(28-31)33-2)26-22-24-12-17(23)20(27-22)16-11-25-30-8-4-3-5-19(16)30/h3-5,8,11-13,15H,6-7,9-10H2,1-2H3,(H,24,26,27)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	49	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca Curated by ChEMBL					Assay Description Inhibition of recombinant human IGF-1R using fluorescent labeled FL-KKSRGDYMTMQIG-CONH2 as substrate after 1 hr 50 mins				J Med Chem 59: 4859-66 (2016) BindingDB Entry DOI: 10.7270/Q2KS6TG9
					More data for this Ligand-Target Pair
1,3-beta-glucan synthase component GSC2 (Saccharomyces cerevisiae)	BDBM50184474 (CHEMBL3823522) Show SMILES COc1nn(cc1Nc1ncc(Cl)c(n1)-c1cnn2ccccc12)C1CCN(CC1)C(C)=O Show InChI InChI=1S/C22H23ClN8O2/c1-14(32)29-9-6-15(7-10-29)31-13-18(21(28-31)33-2)26-22-24-12-17(23)20(27-22)16-11-25-30-8-4-3-5-19(16)30/h3-5,8,11-13,15H,6-7,9-10H2,1-2H3,(H,24,26,27)	KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca Curated by ChEMBL					Assay Description Inhibition of human ERG expressed in CHOK1 cells after 6 mins by electrophysiology assay				J Med Chem 59: 4859-66 (2016) BindingDB Entry DOI: 10.7270/Q2KS6TG9
					More data for this Ligand-Target Pair
Insulin-like growth factor 1 receptor (Homo sapiens (Human))	BDBM50184474 (CHEMBL3823522) Show SMILES COc1nn(cc1Nc1ncc(Cl)c(n1)-c1cnn2ccccc12)C1CCN(CC1)C(C)=O Show InChI InChI=1S/C22H23ClN8O2/c1-14(32)29-9-6-15(7-10-29)31-13-18(21(28-31)33-2)26-22-24-12-17(23)20(27-22)16-11-25-30-8-4-3-5-19(16)30/h3-5,8,11-13,15H,6-7,9-10H2,1-2H3,(H,24,26,27)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	46	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca Curated by ChEMBL					Assay Description Inhibition of IGF1-induced human IGF1R autophosphorylation expressed in IGF-1R knock-out mouse fibroblasts				J Med Chem 59: 4859-66 (2016) BindingDB Entry DOI: 10.7270/Q2KS6TG9
					More data for this Ligand-Target Pair
Cyclin-dependent kinase 2 (Homo sapiens (Human))	BDBM50184474 (CHEMBL3823522) Show SMILES COc1nn(cc1Nc1ncc(Cl)c(n1)-c1cnn2ccccc12)C1CCN(CC1)C(C)=O Show InChI InChI=1S/C22H23ClN8O2/c1-14(32)29-9-6-15(7-10-29)31-13-18(21(28-31)33-2)26-22-24-12-17(23)20(27-22)16-11-25-30-8-4-3-5-19(16)30/h3-5,8,11-13,15H,6-7,9-10H2,1-2H3,(H,24,26,27)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	361	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca Curated by ChEMBL					Assay Description Inhibition of CDK2 (unknown origin)				J Med Chem 59: 4859-66 (2016) BindingDB Entry DOI: 10.7270/Q2KS6TG9
					More data for this Ligand-Target Pair