BDBM50184484 5-(2-pyridin-2-yl-5,6-dihydro-4H-pyrrolo[1,2-b]pyrazol-3-yl)-1-[3-(tetrahydro-pyran-2-yloxy)-propyl]-1H-benzoimidazole::CHEMBL204158

SMILES: C(COC1CCCCO1)Cn1cnc2cc(ccc12)-c1c2CCCn2nc1-c1ccccn1

InChI Key: InChIKey=VTPAYYPWGCIXCD-UHFFFAOYSA-N

Data: 4 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50184484   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
TGF-beta receptor type-1 (Homo sapiens (Human))	BDBM50184484 (5-(2-pyridin-2-yl-5,6-dihydro-4H-pyrrolo[1,2-b]pyr...) Show SMILES C(COC1CCCCO1)Cn1cnc2cc(ccc12)-c1c2CCCn2nc1-c1ccccn1 Show InChI InChI=1S/C26H29N5O2/c1-3-12-27-20(7-1)26-25(23-8-5-14-31(23)29-26)19-10-11-22-21(17-19)28-18-30(22)13-6-16-33-24-9-2-4-15-32-24/h1,3,7,10-12,17-18,24H,2,4-6,8-9,13-16H2	PDB MMDB UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	6.58E+3	n/a	n/a	n/a	n/a	n/a	n/a
Lilly Research Laboratory Curated by ChEMBL					Assay Description Inhibition of recombinant human TGFbeta R1 expressed in Sf9 cells				J Med Chem 49: 2138-42 (2006) Article DOI: 10.1021/jm058209g BindingDB Entry DOI: 10.7270/Q2V40TS0
					More data for this Ligand-Target Pair
TGF-beta receptor type-2 (Homo sapiens (Human))	BDBM50184484 (5-(2-pyridin-2-yl-5,6-dihydro-4H-pyrrolo[1,2-b]pyr...) Show SMILES C(COC1CCCCO1)Cn1cnc2cc(ccc12)-c1c2CCCn2nc1-c1ccccn1 Show InChI InChI=1S/C26H29N5O2/c1-3-12-27-20(7-1)26-25(23-8-5-14-31(23)29-26)19-10-11-22-21(17-19)28-18-30(22)13-6-16-33-24-9-2-4-15-32-24/h1,3,7,10-12,17-18,24H,2,4-6,8-9,13-16H2	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	>2.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Lilly Research Laboratory Curated by ChEMBL					Assay Description Inhibition of recombinant human TGFbeta R2 expressed in Sf9 cells				J Med Chem 49: 2138-42 (2006) Article DOI: 10.1021/jm058209g BindingDB Entry DOI: 10.7270/Q2V40TS0
					More data for this Ligand-Target Pair
TGF-beta receptor type-1 (Homo sapiens (Human))	BDBM50184484 (5-(2-pyridin-2-yl-5,6-dihydro-4H-pyrrolo[1,2-b]pyr...) Show SMILES C(COC1CCCCO1)Cn1cnc2cc(ccc12)-c1c2CCCn2nc1-c1ccccn1 Show InChI InChI=1S/C26H29N5O2/c1-3-12-27-20(7-1)26-25(23-8-5-14-31(23)29-26)19-10-11-22-21(17-19)28-18-30(22)13-6-16-33-24-9-2-4-15-32-24/h1,3,7,10-12,17-18,24H,2,4-6,8-9,13-16H2	PDB MMDB UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	5.89E+3	n/a	n/a	n/a	n/a	n/a	n/a
Lilly Research Laboratory Curated by ChEMBL					Assay Description Inhibition of TGFbeta R1 induced transcriptional activation of p3TP-Lux in mink Mv1Lu lung cells				J Med Chem 49: 2138-42 (2006) Article DOI: 10.1021/jm058209g BindingDB Entry DOI: 10.7270/Q2V40TS0
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 20 (Homo sapiens (Human))	BDBM50184484 (5-(2-pyridin-2-yl-5,6-dihydro-4H-pyrrolo[1,2-b]pyr...) Show SMILES C(COC1CCCCO1)Cn1cnc2cc(ccc12)-c1c2CCCn2nc1-c1ccccn1 Show InChI InChI=1S/C26H29N5O2/c1-3-12-27-20(7-1)26-25(23-8-5-14-31(23)29-26)19-10-11-22-21(17-19)28-18-30(22)13-6-16-33-24-9-2-4-15-32-24/h1,3,7,10-12,17-18,24H,2,4-6,8-9,13-16H2	PDB NCI pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	>2.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Lilly Research Laboratory Curated by ChEMBL					Assay Description Inhibition of MLK7				J Med Chem 49: 2138-42 (2006) Article DOI: 10.1021/jm058209g BindingDB Entry DOI: 10.7270/Q2V40TS0
					More data for this Ligand-Target Pair