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SMILES: C1Cc2c(c(nn2C1)-c1ccccn1)-c1ccc2[nH]ccc2c1

InChI Key: InChIKey=QHMHAHQOXJQUDW-UHFFFAOYSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50184498   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Mitogen-activated protein kinase kinase kinase 20 (Homo sapiens (Human))	BDBM50184498 (5-(2-pyridin-2-yl-5,6-dihydro-4H-pyrrolo[1,2-b]pyr...) Show SMILES C1Cc2c(c(nn2C1)-c1ccccn1)-c1ccc2[nH]ccc2c1 Show InChI InChI=1S/C19H16N4/c1-2-9-20-16(4-1)19-18(17-5-3-11-23(17)22-19)14-6-7-15-13(12-14)8-10-21-15/h1-2,4,6-10,12,21H,3,5,11H2	PDB NCI pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	>2.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Lilly Research Laboratory Curated by ChEMBL					Assay Description Inhibition of MLK7				J Med Chem 49: 2138-42 (2006) Article DOI: 10.1021/jm058209g BindingDB Entry DOI: 10.7270/Q2V40TS0
					More data for this Ligand-Target Pair
TGF-beta receptor type-2 (Homo sapiens (Human))	BDBM50184498 (5-(2-pyridin-2-yl-5,6-dihydro-4H-pyrrolo[1,2-b]pyr...) Show SMILES C1Cc2c(c(nn2C1)-c1ccccn1)-c1ccc2[nH]ccc2c1 Show InChI InChI=1S/C19H16N4/c1-2-9-20-16(4-1)19-18(17-5-3-11-23(17)22-19)14-6-7-15-13(12-14)8-10-21-15/h1-2,4,6-10,12,21H,3,5,11H2	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	>2.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Lilly Research Laboratory Curated by ChEMBL					Assay Description Inhibition of recombinant human TGFbeta R2 expressed in Sf9 cells				J Med Chem 49: 2138-42 (2006) Article DOI: 10.1021/jm058209g BindingDB Entry DOI: 10.7270/Q2V40TS0
					More data for this Ligand-Target Pair
TGF-beta receptor type-1 (Homo sapiens (Human))	BDBM50184498 (5-(2-pyridin-2-yl-5,6-dihydro-4H-pyrrolo[1,2-b]pyr...) Show SMILES C1Cc2c(c(nn2C1)-c1ccccn1)-c1ccc2[nH]ccc2c1 Show InChI InChI=1S/C19H16N4/c1-2-9-20-16(4-1)19-18(17-5-3-11-23(17)22-19)14-6-7-15-13(12-14)8-10-21-15/h1-2,4,6-10,12,21H,3,5,11H2	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	>2.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Lilly Research Laboratory Curated by ChEMBL					Assay Description Inhibition of recombinant human TGFbeta R1 expressed in Sf9 cells				J Med Chem 49: 2138-42 (2006) Article DOI: 10.1021/jm058209g BindingDB Entry DOI: 10.7270/Q2V40TS0
					More data for this Ligand-Target Pair