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Enter Data

BDBM50184737 CHEMBL378563::N-(4-(trifluoromethyl)phenyl)-4-(3-(trifluoromethyl)pyridin-2-yl)benzamide

SMILES: FC(F)(F)c1ccc(NC(=O)c2ccc(cc2)-c2ncccc2C(F)(F)F)cc1

InChI Key: InChIKey=YOCQLGXBNLZHFA-UHFFFAOYSA-N

Data: 6 IC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50184737
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Transient receptor potential cation channel subfamily V member 1 (Homo sapiens (Human))	BDBM50184737 (CHEMBL378563 \| N-(4-(trifluoromethyl)phenyl)-4-(3-...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	13	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Curated by ChEMBL					Assay Description Antagonist activity against capsaicin-induced intracellular calcium ion increase in CHO cells expressing human TRPV1 in FLIPR assay				Bioorg Med Chem Lett 16: 2872-6 (2006) Article DOI: 10.1016/j.bmcl.2006.03.004 BindingDB Entry DOI: 10.7270/Q2959H50
Merck Sharp & Dohme Curated by ChEMBL					More data for this Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1 (Homo sapiens (Human))	BDBM50184737 (CHEMBL378563 \| N-(4-(trifluoromethyl)phenyl)-4-(3-...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	3	n/a	n/a	n/a	n/a	5.5	n/a
Merck Sharp & Dohme Curated by ChEMBL					Assay Description Inhibition of acidic pH 5.5-stimulated current in CHO cells expressing human TRPV1 receptor by patch clamp				Bioorg Med Chem Lett 16: 2872-6 (2006) Article DOI: 10.1016/j.bmcl.2006.03.004 BindingDB Entry DOI: 10.7270/Q2959H50
Merck Sharp & Dohme Curated by ChEMBL					More data for this Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1 (Homo sapiens (Human))	BDBM50184737 (CHEMBL378563 \| N-(4-(trifluoromethyl)phenyl)-4-(3-...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	14	n/a	n/a	n/a	n/a	n/a	n/a
Neurogen Corporation Curated by ChEMBL					Assay Description Inhibition of human TRPV1				J Med Chem 53: 3330-48 (2010) Article DOI: 10.1021/jm100051g BindingDB Entry DOI: 10.7270/Q2474BTP
Neurogen Corporation Curated by ChEMBL					More data for this Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1 (Homo sapiens (Human))	BDBM50184737 (CHEMBL378563 \| N-(4-(trifluoromethyl)phenyl)-4-(3-...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	14	n/a	n/a	n/a	n/a	n/a	n/a
Neurogen Corporation Curated by ChEMBL					Assay Description Antagonist activity at human TRPV1 receptor assessed as inhibition of capsaicin-induced activation				Bioorg Med Chem Lett 18: 4573-7 (2008) Article DOI: 10.1016/j.bmcl.2008.07.036 BindingDB Entry DOI: 10.7270/Q28P6099
Neurogen Corporation Curated by ChEMBL					More data for this Ligand-Target Pair
Vanilloid receptor (Rattus norvegicus (rat))	BDBM50184737 (CHEMBL378563 \| N-(4-(trifluoromethyl)phenyl)-4-(3-...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	26	n/a	n/a	n/a	n/a	n/a	n/a
Neurogen Corporation Curated by ChEMBL					Assay Description Antagonist activity against low pH(5.0-5.5)-activated rat VR1				Bioorg Med Chem Lett 16: 5217-21 (2006) Article DOI: 10.1016/j.bmcl.2006.07.010 BindingDB Entry DOI: 10.7270/Q2XP74KT
Neurogen Corporation Curated by ChEMBL					More data for this Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1 (Homo sapiens (Human))	BDBM50184737 (CHEMBL378563 \| N-(4-(trifluoromethyl)phenyl)-4-(3-...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	14	n/a	n/a	n/a	n/a	n/a	n/a
Neurogen Corporation Curated by ChEMBL					Assay Description Antagonist activity against capsaicin-activated human VR1 by FLIPR assay				Bioorg Med Chem Lett 16: 5217-21 (2006) Article DOI: 10.1016/j.bmcl.2006.07.010 BindingDB Entry DOI: 10.7270/Q2XP74KT
Neurogen Corporation Curated by ChEMBL					More data for this Ligand-Target Pair