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BDBM50185152 CHEMBL3822475

SMILES: COc1cc(ccc1Nc1ncc(Cl)c(Nc2ccccc2S(C)(=O)=O)n1)N1CCC(CC1)N1CCN(C)CC1

InChI Key: InChIKey=ZCTVEBRXLFXVIK-UHFFFAOYSA-N

Data: 3 IC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50185152   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Insulin receptor


(Homo sapiens (Human))
BDBM50185152
PNG
(CHEMBL3822475)
Show SMILES COc1cc(ccc1Nc1ncc(Cl)c(Nc2ccccc2S(C)(=O)=O)n1)N1CCC(CC1)N1CCN(C)CC1
Show InChI InChI=1S/C28H36ClN7O3S/c1-34-14-16-36(17-15-34)20-10-12-35(13-11-20)21-8-9-23(25(18-21)39-2)32-28-30-19-22(29)27(33-28)31-24-6-4-5-7-26(24)40(3,37)38/h4-9,18-20H,10-17H2,1-3H3,(H2,30,31,32,33)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
PubMed
n/an/a 5.10n/an/an/an/an/an/a



ARIAD Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Inhibition of human InsR using myelin basic protein as substrate and [gamma-33P]ATP measured after 1 hr


J Med Chem 59: 4948-64 (2016)


BindingDB Entry DOI: 10.7270/Q2NK3H0Q
More data for this
Ligand-Target Pair
ALK tyrosine kinase receptor


(Homo sapiens (Human))
BDBM50185152
PNG
(CHEMBL3822475)
Show SMILES COc1cc(ccc1Nc1ncc(Cl)c(Nc2ccccc2S(C)(=O)=O)n1)N1CCC(CC1)N1CCN(C)CC1
Show InChI InChI=1S/C28H36ClN7O3S/c1-34-14-16-36(17-15-34)20-10-12-35(13-11-20)21-8-9-23(25(18-21)39-2)32-28-30-19-22(29)27(33-28)31-24-6-4-5-7-26(24)40(3,37)38/h4-9,18-20H,10-17H2,1-3H3,(H2,30,31,32,33)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
PubMed
n/an/a 0.590n/an/an/an/an/an/a



ARIAD Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Inhibition of human ALK using poly[Glu:Tyr] (4:1) as substrate and [gamma-33P]ATP measured after 1 hr


J Med Chem 59: 4948-64 (2016)


BindingDB Entry DOI: 10.7270/Q2NK3H0Q
More data for this
Ligand-Target Pair
Insulin-like growth factor I receptor


(Homo sapiens (Human))
BDBM50185152
PNG
(CHEMBL3822475)
Show SMILES COc1cc(ccc1Nc1ncc(Cl)c(Nc2ccccc2S(C)(=O)=O)n1)N1CCC(CC1)N1CCN(C)CC1
Show InChI InChI=1S/C28H36ClN7O3S/c1-34-14-16-36(17-15-34)20-10-12-35(13-11-20)21-8-9-23(25(18-21)39-2)32-28-30-19-22(29)27(33-28)31-24-6-4-5-7-26(24)40(3,37)38/h4-9,18-20H,10-17H2,1-3H3,(H2,30,31,32,33)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
PubMed
n/an/a 0.760n/an/an/an/an/an/a



ARIAD Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Inhibition of human IGF1R using KKKSPGEYVNIEFG as substrate and [gamma-33P]ATP measured after 1 hr


J Med Chem 59: 4948-64 (2016)


BindingDB Entry DOI: 10.7270/Q2NK3H0Q
More data for this
Ligand-Target Pair