BDBM50185158 CHEMBL210091::H-Tyr-Val-Gln-Leu-VE

SMILES: CCOC(=O)\C=C\[C@H](CC(C)C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(C)C

InChI Key: InChIKey=JSGMPWLDSQFOIU-YLKYAQCOSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50185158   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Proteasome Macropain subunit (Homo sapiens (Human))	BDBM50185158 (CHEMBL210091 | H-Tyr-Val-Gln-Leu-VE) Show SMILES CCOC(=O)\C=C\[C@H](CC(C)C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(C)C Show InChI InChI=1S/C29H45N5O7/c1-6-41-25(37)14-9-20(15-17(2)3)32-28(39)23(12-13-24(31)36)33-29(40)26(18(4)5)34-27(38)22(30)16-19-7-10-21(35)11-8-19/h7-11,14,17-18,20,22-23,26,35H,6,12-13,15-16,30H2,1-5H3,(H2,31,36)(H,32,39)(H,33,40)(H,34,38)/b14-9+/t20-,22+,23+,26+/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	83	n/a	n/a	n/a	n/a	n/a	n/a
University of Ferrara Curated by ChEMBL					Assay Description Inhibition of trypsin like activity of proteasome				Bioorg Med Chem Lett 16: 3125-30 (2006) Article DOI: 10.1016/j.bmcl.2006.03.070 BindingDB Entry DOI: 10.7270/Q2TX3G5J
					More data for this Ligand-Target Pair
20S proteasome chymotrypsin-like (Homo sapiens (Human))	BDBM50185158 (CHEMBL210091 | H-Tyr-Val-Gln-Leu-VE) Show SMILES CCOC(=O)\C=C\[C@H](CC(C)C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(C)C Show InChI InChI=1S/C29H45N5O7/c1-6-41-25(37)14-9-20(15-17(2)3)32-28(39)23(12-13-24(31)36)33-29(40)26(18(4)5)34-27(38)22(30)16-19-7-10-21(35)11-8-19/h7-11,14,17-18,20,22-23,26,35H,6,12-13,15-16,30H2,1-5H3,(H2,31,36)(H,32,39)(H,33,40)(H,34,38)/b14-9+/t20-,22+,23+,26+/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	4.32E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Ferrara Curated by ChEMBL					Assay Description Inhibition of chymotrypsin like activity of proteasome				Bioorg Med Chem Lett 16: 3125-30 (2006) Article DOI: 10.1016/j.bmcl.2006.03.070 BindingDB Entry DOI: 10.7270/Q2TX3G5J
					More data for this Ligand-Target Pair