BDBM50185751 CHEMBL1602143

SMILES: COc1ccc2nc(Nc3nc(O)cc(CSc4nnnn4-c4ccccc4)n3)nc(C)c2c1

InChI Key: InChIKey=WPETYAZUCHPYIM-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50185751   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Histone-lysine N-methyltransferase EZH2 (Homo sapiens (Human))	BDBM50185751 (CHEMBL1602143) Show SMILES COc1ccc2nc(Nc3nc(O)cc(CSc4nnnn4-c4ccccc4)n3)nc(C)c2c1 Show InChI InChI=1S/C22H19N9O2S/c1-13-17-11-16(33-2)8-9-18(17)25-20(23-13)27-21-24-14(10-19(32)26-21)12-34-22-28-29-30-31(22)15-6-4-3-5-7-15/h3-11H,12H2,1-2H3,(H2,23,24,25,26,27,32)	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	2.26E+4	n/a	n/a	n/a	n/a	n/a	n/a
College of Chemical and Environmental Engineering Curated by ChEMBL					Assay Description Inhibition of PRC2 EZH2 sub unit (unknown origin) assessed as inhibition of SAM-mediated methyl transfer process preincubated for 15 mins followed by...				Bioorg Med Chem Lett 26: 3813-7 (2016) BindingDB Entry DOI: 10.7270/Q23N259Z
					More data for this Ligand-Target Pair