BDBM50185797 1-((R)-3-amino-2-hydroxypropyl)-3-(1-(1,2-dihydroacenaphthylen-1-yl)-1,2,3,6-tetrahydropyridin-4-yl)-1H-indole-5-carbonitrile::CHEMBL378453
SMILES: NC[C@@H](O)Cn1cc(C2=CCN(CC2)C2Cc3cccc4cccc2c34)c2cc(ccc12)C#N
InChI Key: InChIKey=CTZWWIABADGLMN-YFIOFSHDSA-N
Data: 4 KI
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
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Nociceptin receptor (Homo sapiens (Human)) | BDBM50185797 (1-((R)-3-amino-2-hydroxypropyl)-3-(1-(1,2-dihydroa...) | PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 1.65E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Johnson & Johnson Pharmaceutical Research and Development Curated by ChEMBL | Assay Description Agonist activity at ORL1 receptor expressed in HEK293 cells by calciun flux assay | Bioorg Med Chem Lett 16: 3524-8 (2006) Article DOI: 10.1016/j.bmcl.2006.03.094 BindingDB Entry DOI: 10.7270/Q2VT1RQJ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Mu-type opioid receptor (Homo sapiens (Human)) | BDBM50185797 (1-((R)-3-amino-2-hydroxypropyl)-3-(1-(1,2-dihydroa...) | PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 4.14E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Johnson & Johnson Pharmaceutical Research and Development Curated by ChEMBL | Assay Description Displacement of [3H]DAMGO from mu opioid receptor expressed in HEK293 cells | Bioorg Med Chem Lett 16: 3524-8 (2006) Article DOI: 10.1016/j.bmcl.2006.03.094 BindingDB Entry DOI: 10.7270/Q2VT1RQJ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Delta-type opioid receptor (Homo sapiens (Human)) | BDBM50185797 (1-((R)-3-amino-2-hydroxypropyl)-3-(1-(1,2-dihydroa...) | PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | >5.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Johnson & Johnson Pharmaceutical Research and Development Curated by ChEMBL | Assay Description Displacement of [3H]DDPDE from delta opioid receptor expressed in HEK293 cells | Bioorg Med Chem Lett 16: 3524-8 (2006) Article DOI: 10.1016/j.bmcl.2006.03.094 BindingDB Entry DOI: 10.7270/Q2VT1RQJ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Kappa-type opioid receptor (Homo sapiens (Human)) | BDBM50185797 (1-((R)-3-amino-2-hydroxypropyl)-3-(1-(1,2-dihydroa...) | PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | >5.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Johnson & Johnson Pharmaceutical Research and Development Curated by ChEMBL | Assay Description Displacement of [3H]U-69593 from kappa opioid receptor expressed in HEK293 cells | Bioorg Med Chem Lett 16: 3524-8 (2006) Article DOI: 10.1016/j.bmcl.2006.03.094 BindingDB Entry DOI: 10.7270/Q2VT1RQJ | |||||||||||
More data for this Ligand-Target Pair |