Found 5 hits for monomerid = 50185884 Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Matrix metalloproteinase-9
(Homo sapiens (Human)) | BDBM50185884
(4-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-2-(4-p-tol...)Show SMILES Cc1ccc(cc1)C#Cc1ccc(cc1)S(=O)(=O)C(CCN1C(=O)c2ccccc2C1=O)C(O)=O Show InChI InChI=1S/C27H21NO6S/c1-18-6-8-19(9-7-18)10-11-20-12-14-21(15-13-20)35(33,34)24(27(31)32)16-17-28-25(29)22-4-2-3-5-23(22)26(28)30/h2-9,12-15,24H,16-17H2,1H3,(H,31,32) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 0.5 | n/a | n/a | n/a | n/a | n/a | n/a |
Johnson & Johnson Pharmaceutical Research and Development
Curated by ChEMBL
| Assay Description Inhibition of MMP9 |
Bioorg Med Chem Lett 16: 3096-100 (2006)
Article DOI: 10.1016/j.bmcl.2006.03.065 BindingDB Entry DOI: 10.7270/Q2M90886 |
More data for this Ligand-Target Pair | |
Collagenase 3
(Homo sapiens (Human)) | BDBM50185884
(4-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-2-(4-p-tol...)Show SMILES Cc1ccc(cc1)C#Cc1ccc(cc1)S(=O)(=O)C(CCN1C(=O)c2ccccc2C1=O)C(O)=O Show InChI InChI=1S/C27H21NO6S/c1-18-6-8-19(9-7-18)10-11-20-12-14-21(15-13-20)35(33,34)24(27(31)32)16-17-28-25(29)22-4-2-3-5-23(22)26(28)30/h2-9,12-15,24H,16-17H2,1H3,(H,31,32) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 1.40 | n/a | n/a | n/a | n/a | n/a | n/a |
Johnson & Johnson Pharmaceutical Research and Development
Curated by ChEMBL
| Assay Description Inhibition of MMP13 |
Bioorg Med Chem Lett 16: 3096-100 (2006)
Article DOI: 10.1016/j.bmcl.2006.03.065 BindingDB Entry DOI: 10.7270/Q2M90886 |
More data for this Ligand-Target Pair | |
72 kDa type IV collagenase
(Homo sapiens (Human)) | BDBM50185884
(4-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-2-(4-p-tol...)Show SMILES Cc1ccc(cc1)C#Cc1ccc(cc1)S(=O)(=O)C(CCN1C(=O)c2ccccc2C1=O)C(O)=O Show InChI InChI=1S/C27H21NO6S/c1-18-6-8-19(9-7-18)10-11-20-12-14-21(15-13-20)35(33,34)24(27(31)32)16-17-28-25(29)22-4-2-3-5-23(22)26(28)30/h2-9,12-15,24H,16-17H2,1H3,(H,31,32) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 0.700 | n/a | n/a | n/a | n/a | n/a | n/a |
Johnson & Johnson Pharmaceutical Research and Development
Curated by ChEMBL
| Assay Description Inhibition of MMP2 |
Bioorg Med Chem Lett 16: 3096-100 (2006)
Article DOI: 10.1016/j.bmcl.2006.03.065 BindingDB Entry DOI: 10.7270/Q2M90886 |
More data for this Ligand-Target Pair | |
Stromelysin-1
(Homo sapiens (Human)) | BDBM50185884
(4-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-2-(4-p-tol...)Show SMILES Cc1ccc(cc1)C#Cc1ccc(cc1)S(=O)(=O)C(CCN1C(=O)c2ccccc2C1=O)C(O)=O Show InChI InChI=1S/C27H21NO6S/c1-18-6-8-19(9-7-18)10-11-20-12-14-21(15-13-20)35(33,34)24(27(31)32)16-17-28-25(29)22-4-2-3-5-23(22)26(28)30/h2-9,12-15,24H,16-17H2,1H3,(H,31,32) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 28 | n/a | n/a | n/a | n/a | n/a | n/a |
Johnson & Johnson Pharmaceutical Research and Development
Curated by ChEMBL
| Assay Description Inhibition of MMP3 |
Bioorg Med Chem Lett 16: 3096-100 (2006)
Article DOI: 10.1016/j.bmcl.2006.03.065 BindingDB Entry DOI: 10.7270/Q2M90886 |
More data for this Ligand-Target Pair | |
Interstitial collagenase
(Homo sapiens (Human)) | BDBM50185884
(4-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-2-(4-p-tol...)Show SMILES Cc1ccc(cc1)C#Cc1ccc(cc1)S(=O)(=O)C(CCN1C(=O)c2ccccc2C1=O)C(O)=O Show InChI InChI=1S/C27H21NO6S/c1-18-6-8-19(9-7-18)10-11-20-12-14-21(15-13-20)35(33,34)24(27(31)32)16-17-28-25(29)22-4-2-3-5-23(22)26(28)30/h2-9,12-15,24H,16-17H2,1H3,(H,31,32) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | >1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Johnson & Johnson Pharmaceutical Research and Development
Curated by ChEMBL
| Assay Description Inhibition of MMP1 |
Bioorg Med Chem Lett 16: 3096-100 (2006)
Article DOI: 10.1016/j.bmcl.2006.03.065 BindingDB Entry DOI: 10.7270/Q2M90886 |
More data for this Ligand-Target Pair | |