BDBM50186073 CHEMBL210229::N-(2-(dimethylamino)ethyl)-8-isopropyl-9-oxo-8,9-dihydrothiazolo[5,4-f]quinazoline-2-carboxamidine::N-(2-Dimethylamino-ethyl)-8-isopopyl-9-oxo-8,9-dihydro[1,3]thiazolo[5,4-f]quinazoline-2-carboxamidine

SMILES: CC(C)n1cnc2ccc3nc(sc3c2c1=O)C(=N)NCCN(C)C

InChI Key: InChIKey=QIYPQJHMRBXGMO-UHFFFAOYSA-N

Data: 6 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50186073   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Cyclin B/Cyclin-Dependent Kinase 1 (CDK1)/G2/mitotic-specific cyclin B2/G2/mitotic-specific cyclin B3 (Homo sapiens (Human))	BDBM50186073 (CHEMBL210229 | N-(2-(dimethylamino)ethyl)-8-isopro...) Show SMILES CC(C)n1cnc2ccc3nc(sc3c2c1=O)C(=N)NCCN(C)C Show InChI InChI=1S/C17H22N6OS/c1-10(2)23-9-20-11-5-6-12-14(13(11)17(23)24)25-16(21-12)15(18)19-7-8-22(3)4/h5-6,9-10H,7-8H2,1-4H3,(H2,18,19)	PDB UniProtKB/SwissProt antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Université de La Rochelle Curated by ChEMBL					Assay Description Inhibition of CDK1/cyclinB in presence of 15 uM ATP				Bioorg Med Chem Lett 16: 3419-23 (2006) Article DOI: 10.1016/j.bmcl.2006.04.006 BindingDB Entry DOI: 10.7270/Q29W0F33
					More data for this Ligand-Target Pair
Cyclin-Dependent Kinase 5 (CDK5) (Homo sapiens (Human))	BDBM50186073 (CHEMBL210229 | N-(2-(dimethylamino)ethyl)-8-isopro...) Show SMILES CC(C)n1cnc2ccc3nc(sc3c2c1=O)C(=N)NCCN(C)C Show InChI InChI=1S/C17H22N6OS/c1-10(2)23-9-20-11-5-6-12-14(13(11)17(23)24)25-16(21-12)15(18)19-7-8-22(3)4/h5-6,9-10H,7-8H2,1-4H3,(H2,18,19)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	4.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Université de La Rochelle Curated by ChEMBL					Assay Description Inhibition of CDK5/p25 in presence of 15 uM ATP				Bioorg Med Chem Lett 16: 3419-23 (2006) Article DOI: 10.1016/j.bmcl.2006.04.006 BindingDB Entry DOI: 10.7270/Q29W0F33
					More data for this Ligand-Target Pair
Cyclin-dependent kinase 1 (Homo sapiens (Human))	BDBM50186073 (CHEMBL210229 | N-(2-(dimethylamino)ethyl)-8-isopro...) Show SMILES CC(C)n1cnc2ccc3nc(sc3c2c1=O)C(=N)NCCN(C)C Show InChI InChI=1S/C17H22N6OS/c1-10(2)23-9-20-11-5-6-12-14(13(11)17(23)24)25-16(21-12)15(18)19-7-8-22(3)4/h5-6,9-10H,7-8H2,1-4H3,(H2,18,19)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Université de Nantes Curated by ChEMBL					Assay Description Inhibition of CDK1 (unknown origin)				Eur J Med Chem 43: 1469-77 (2008) Article DOI: 10.1016/j.ejmech.2007.09.020 BindingDB Entry DOI: 10.7270/Q24M9495
					More data for this Ligand-Target Pair
Cyclin-dependent-like kinase 5 (Homo sapiens (Human))	BDBM50186073 (CHEMBL210229 | N-(2-(dimethylamino)ethyl)-8-isopro...) Show SMILES CC(C)n1cnc2ccc3nc(sc3c2c1=O)C(=N)NCCN(C)C Show InChI InChI=1S/C17H22N6OS/c1-10(2)23-9-20-11-5-6-12-14(13(11)17(23)24)25-16(21-12)15(18)19-7-8-22(3)4/h5-6,9-10H,7-8H2,1-4H3,(H2,18,19)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	4.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Université de Nantes Curated by ChEMBL					Assay Description Inhibition of CDK5/p25 (unknown origin)				Eur J Med Chem 43: 1469-77 (2008) Article DOI: 10.1016/j.ejmech.2007.09.020 BindingDB Entry DOI: 10.7270/Q24M9495
					More data for this Ligand-Target Pair
Glycogen synthase kinase-3 (Homo sapiens (Human))	BDBM50186073 (CHEMBL210229 | N-(2-(dimethylamino)ethyl)-8-isopro...) Show SMILES CC(C)n1cnc2ccc3nc(sc3c2c1=O)C(=N)NCCN(C)C Show InChI InChI=1S/C17H22N6OS/c1-10(2)23-9-20-11-5-6-12-14(13(11)17(23)24)25-16(21-12)15(18)19-7-8-22(3)4/h5-6,9-10H,7-8H2,1-4H3,(H2,18,19)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	560	n/a	n/a	n/a	n/a	n/a	n/a
Université de Nantes Curated by ChEMBL					Assay Description Inhibition of GSK3alpha/beta (unknown origin)				Eur J Med Chem 43: 1469-77 (2008) Article DOI: 10.1016/j.ejmech.2007.09.020 BindingDB Entry DOI: 10.7270/Q24M9495
					More data for this Ligand-Target Pair
Cyclin-dependent kinase 1 (Homo sapiens (Human))	BDBM50186073 (CHEMBL210229 | N-(2-(dimethylamino)ethyl)-8-isopro...) Show SMILES CC(C)n1cnc2ccc3nc(sc3c2c1=O)C(=N)NCCN(C)C Show InChI InChI=1S/C17H22N6OS/c1-10(2)23-9-20-11-5-6-12-14(13(11)17(23)24)25-16(21-12)15(18)19-7-8-22(3)4/h5-6,9-10H,7-8H2,1-4H3,(H2,18,19)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Université de Nantes Curated by ChEMBL					Assay Description Inhibition of CDK1/cyclinB (unknown origin)				Eur J Med Chem 43: 1469-77 (2008) Article DOI: 10.1016/j.ejmech.2007.09.020 BindingDB Entry DOI: 10.7270/Q24M9495
					More data for this Ligand-Target Pair