BindingDB PrimarySearch

BDBM50186375 CHEMBL210540::N-(5-(2-(cyclohexyloxy)-6-methylpyrimidin-4-yl)thiazol-2-yl)-5-((4-methylpiperazin-1-yl)methyl)pyrazin-2-amine

SMILES: CN1CCN(Cc2cnc(Nc3ncc(s3)-c3cc(C)nc(OC4CCCCC4)n3)cn2)CC1

InChI Key: InChIKey=DLIDUXYWQPLFEM-UHFFFAOYSA-N

Data: 7 IC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50186375
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Cyclin-dependent kinase 7 (Homo sapiens (Human))	BDBM50186375 (CHEMBL210540 \| N-(5-(2-(cyclohexyloxy)-6-methylpyr...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents	Article PubMed	n/a	n/a	530	n/a	n/a	n/a	n/a	n/a	n/a
Banyu Tsukuba Research Institute Curated by ChEMBL					Assay Description Inhibition of CDK7				Bioorg Med Chem Lett 16: 3751-4 (2006) Article DOI: 10.1016/j.bmcl.2006.04.048 BindingDB Entry DOI: 10.7270/Q2N29WK0
Banyu Tsukuba Research Institute Curated by ChEMBL					More data for this Ligand-Target Pair
Cyclin-dependent kinase 6 (Homo sapiens (Human))	BDBM50186375 (CHEMBL210540 \| N-(5-(2-(cyclohexyloxy)-6-methylpyr...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents	Article PubMed	n/a	n/a	7.80	n/a	n/a	n/a	n/a	n/a	n/a
Banyu Tsukuba Research Institute Curated by ChEMBL					Assay Description Inhibition of CDK6				Bioorg Med Chem Lett 16: 3751-4 (2006) Article DOI: 10.1016/j.bmcl.2006.04.048 BindingDB Entry DOI: 10.7270/Q2N29WK0
Banyu Tsukuba Research Institute Curated by ChEMBL					More data for this Ligand-Target Pair
Cyclin-dependent kinase 4 (Homo sapiens (Human))	BDBM50186375 (CHEMBL210540 \| N-(5-(2-(cyclohexyloxy)-6-methylpyr...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents	Article PubMed	n/a	n/a	9.20	n/a	n/a	n/a	n/a	n/a	n/a
Banyu Tsukuba Research Institute Curated by ChEMBL					Assay Description Inhibition of CDK4				Bioorg Med Chem Lett 16: 3751-4 (2006) Article DOI: 10.1016/j.bmcl.2006.04.048 BindingDB Entry DOI: 10.7270/Q2N29WK0
Banyu Tsukuba Research Institute Curated by ChEMBL					More data for this Ligand-Target Pair
Cyclin-dependent kinase 9 (Homo sapiens (Human))	BDBM50186375 (CHEMBL210540 \| N-(5-(2-(cyclohexyloxy)-6-methylpyr...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents	Article PubMed	n/a	n/a	2.50E+3	n/a	n/a	n/a	n/a	n/a	n/a
Banyu Tsukuba Research Institute Curated by ChEMBL					Assay Description Inhibition of CDK9				Bioorg Med Chem Lett 16: 3751-4 (2006) Article DOI: 10.1016/j.bmcl.2006.04.048 BindingDB Entry DOI: 10.7270/Q2N29WK0
Banyu Tsukuba Research Institute Curated by ChEMBL					More data for this Ligand-Target Pair
Cyclin-dependent kinase 2 (Homo sapiens (Human))	BDBM50186375 (CHEMBL210540 \| N-(5-(2-(cyclohexyloxy)-6-methylpyr...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents	Article PubMed	n/a	n/a	1.70E+3	n/a	n/a	n/a	n/a	n/a	n/a
Banyu Tsukuba Research Institute Curated by ChEMBL					Assay Description Inhibition of CDK2				Bioorg Med Chem Lett 16: 3751-4 (2006) Article DOI: 10.1016/j.bmcl.2006.04.048 BindingDB Entry DOI: 10.7270/Q2N29WK0
Banyu Tsukuba Research Institute Curated by ChEMBL					More data for this Ligand-Target Pair
Cyclin-dependent-like kinase 5 (Homo sapiens (Human))	BDBM50186375 (CHEMBL210540 \| N-(5-(2-(cyclohexyloxy)-6-methylpyr...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents	Article PubMed	n/a	n/a	3.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Banyu Tsukuba Research Institute Curated by ChEMBL					Assay Description Inhibition of CDK5				Bioorg Med Chem Lett 16: 3751-4 (2006) Article DOI: 10.1016/j.bmcl.2006.04.048 BindingDB Entry DOI: 10.7270/Q2N29WK0
Banyu Tsukuba Research Institute Curated by ChEMBL					More data for this Ligand-Target Pair
Cyclin-dependent kinase 1 (Homo sapiens (Human))	BDBM50186375 (CHEMBL210540 \| N-(5-(2-(cyclohexyloxy)-6-methylpyr...) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents	Article PubMed	n/a	n/a	600	n/a	n/a	n/a	n/a	n/a	n/a
Banyu Tsukuba Research Institute Curated by ChEMBL					Assay Description Inhibition of CDK1				Bioorg Med Chem Lett 16: 3751-4 (2006) Article DOI: 10.1016/j.bmcl.2006.04.048 BindingDB Entry DOI: 10.7270/Q2N29WK0
Banyu Tsukuba Research Institute Curated by ChEMBL					More data for this Ligand-Target Pair