BDBM50186841 4'-[(5-fluoro-6-trifluoromethyl-1H-benzoimidazol-2-yl)-piperidin-4-ylidene-methyl]-biphenyl-3-carbonitrile::CHEMBL209993

SMILES: Fc1cc2[nH]c(nc2cc1C(F)(F)F)C(=C1CCNCC1)c1ccc(cc1)-c1cccc(c1)C#N

InChI Key: InChIKey=QZSGUXROLZTHQT-UHFFFAOYSA-N

Data: 1 KI

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50186841   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Melanin-concentrating hormone receptor (Homo sapiens (Human))	BDBM50186841 (4'-[(5-fluoro-6-trifluoromethyl-1H-benzoimidazol-2...) Show SMILES Fc1cc2[nH]c(nc2cc1C(F)(F)F)C(=C1CCNCC1)c1ccc(cc1)-c1cccc(c1)C#N |(25.89,-15.32,;25.13,-16.65,;23.6,-16.65,;22.83,-17.98,;21.33,-18.3,;21.17,-19.83,;22.58,-20.46,;23.6,-19.31,;25.13,-19.31,;25.9,-17.98,;27.44,-17.98,;28.98,-17.98,;27.44,-19.52,;27.44,-16.44,;19.84,-20.6,;19.84,-22.14,;18.5,-22.9,;18.5,-24.44,;19.83,-25.21,;21.17,-24.44,;21.17,-22.9,;18.5,-19.84,;17.17,-20.61,;15.83,-19.84,;15.83,-18.29,;17.16,-17.52,;18.5,-18.29,;14.5,-17.52,;13.18,-18.29,;11.84,-17.53,;11.84,-15.98,;13.17,-15.21,;14.5,-15.98,;13.16,-13.67,;13.16,-12.13,)| Show InChI InChI=1S/C27H20F4N4/c28-22-14-24-23(13-21(22)27(29,30)31)34-26(35-24)25(19-8-10-33-11-9-19)18-6-4-17(5-7-18)20-3-1-2-16(12-20)15-32/h1-7,12-14,33H,8-11H2,(H,34,35)	Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	3.60	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Schering Plough Research Institute Curated by ChEMBL					Assay Description Binding affinity to human MCHR1 assessed as inhibition of MCH-mediated calcium ion influx by FLIPR assay				Bioorg Med Chem Lett 16: 3674-8 (2006) Article DOI: 10.1016/j.bmcl.2006.04.062 BindingDB Entry DOI: 10.7270/Q2XG9QQB
					More data for this Ligand-Target Pair