BDBM50186846 4'-{(5-fluoro-6-trifluoromethyl-1H-benzoimidazol-2-yl)-[1-(1-methyl-1H-pyrrole-2-carbonyl)-piperidin-4-ylidene]-methyl}-biphenyl-3-carbonitrile::CHEMBL268938
SMILES: Cn1cccc1C(=O)N1CCC(CC1)=C(c1nc2cc(c(F)cc2[nH]1)C(F)(F)F)c1ccc(cc1)-c1cccc(c1)C#N
InChI Key: InChIKey=AIHZWBYMNAHLJI-UHFFFAOYSA-N
Data: 1 KI
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Melanin-concentrating hormone receptor (Homo sapiens (Human)) | BDBM50186846 (4'-{(5-fluoro-6-trifluoromethyl-1H-benzoimidazol-2...) | Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 10 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Schering Plough Research Institute Curated by ChEMBL | Assay Description Binding affinity to human MCHR1 assessed as inhibition of MCH-mediated calcium ion influx by FLIPR assay | Bioorg Med Chem Lett 16: 3674-8 (2006) Article DOI: 10.1016/j.bmcl.2006.04.062 BindingDB Entry DOI: 10.7270/Q2XG9QQB | |||||||||||
More data for this Ligand-Target Pair |