BDBM50186854 4'-{(5-fluoro-6-trifluoromethyl-1H-benzoimidazol-2-yl)-[1-(2-hydroxy-ethyl)-piperidin-4-ylidene]-methyl}-biphenyl-3-carbonitrile::CHEMBL209103

SMILES: OCCN1CCC(CC1)=C(c1nc2cc(c(F)cc2[nH]1)C(F)(F)F)c1ccc(cc1)-c1cccc(c1)C#N

InChI Key: InChIKey=UKULPZWRMPMISI-UHFFFAOYSA-N

Data: 1 KI

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50186854   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Melanin-concentrating hormone receptor (Homo sapiens (Human))	BDBM50186854 (4'-{(5-fluoro-6-trifluoromethyl-1H-benzoimidazol-2...) Show SMILES OCCN1CCC(CC1)=C(c1nc2cc(c(F)cc2[nH]1)C(F)(F)F)c1ccc(cc1)-c1cccc(c1)C#N |(.26,-46.09,;.27,-44.55,;1.6,-43.78,;1.6,-42.24,;.27,-41.47,;.27,-39.93,;1.61,-39.17,;2.94,-39.93,;2.94,-41.47,;1.61,-37.63,;2.94,-36.86,;4.35,-37.48,;5.37,-36.34,;6.9,-36.34,;7.67,-35.01,;6.9,-33.68,;7.67,-32.34,;5.37,-33.68,;4.61,-35,;3.1,-35.33,;9.21,-35.01,;10.75,-35.01,;9.21,-36.55,;9.21,-33.47,;.28,-36.86,;-1.06,-37.63,;-2.39,-36.86,;-2.39,-35.32,;-1.06,-34.55,;.27,-35.31,;-3.73,-34.55,;-5.05,-35.32,;-6.38,-34.56,;-6.39,-33.01,;-5.05,-32.24,;-3.72,-33.01,;-5.06,-30.7,;-5.06,-29.16,)| Show InChI InChI=1S/C29H24F4N4O/c30-24-16-26-25(15-23(24)29(31,32)33)35-28(36-26)27(21-8-10-37(11-9-21)12-13-38)20-6-4-19(5-7-20)22-3-1-2-18(14-22)17-34/h1-7,14-16,38H,8-13H2,(H,35,36)	Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	7.20	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Schering Plough Research Institute Curated by ChEMBL					Assay Description Binding affinity to human MCHR1 assessed as inhibition of MCH-mediated calcium ion influx by FLIPR assay				Bioorg Med Chem Lett 16: 3674-8 (2006) Article DOI: 10.1016/j.bmcl.2006.04.062 BindingDB Entry DOI: 10.7270/Q2XG9QQB
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