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BDBM50186968 1-(3-isopropyl-2-methyl-5-oxo-1-(pyrimidin-5-yl)-2,5-dihydro-1H-pyrazol-4-yl)-3-(4-(methylthio)phenyl)urea::CHEMBL211220

SMILES: CSc1ccc(NC(=O)Nc2c(C(C)C)n(C)n(-c3cncnc3)c2=O)cc1

InChI Key: InChIKey=MKWQMWMCGACQFF-UHFFFAOYSA-N

Data: 1 EC50

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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50186968   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
N-formyl peptide receptor 2


(Homo sapiens (Human))
BDBM50186968
PNG
(1-(3-isopropyl-2-methyl-5-oxo-1-(pyrimidin-5-yl)-2...)
Show SMILES CSc1ccc(NC(=O)Nc2c(C(C)C)n(C)n(-c3cncnc3)c2=O)cc1
Show InChI InChI=1S/C19H22N6O2S/c1-12(2)17-16(18(26)25(24(17)3)14-9-20-11-21-10-14)23-19(27)22-13-5-7-15(28-4)8-6-13/h5-12H,1-4H3,(H2,22,23,27)
NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/an/an/a 43n/an/an/an/a



Amgen, Inc.

Curated by ChEMBL


Assay Description
Activity at human FPRL1-mediated calcium mobilization in CHO cells


Bioorg Med Chem Lett 16: 3713-8 (2006)


Article DOI: 10.1016/j.bmcl.2006.04.068
BindingDB Entry DOI: 10.7270/Q2DF6QTJ
More data for this
Ligand-Target Pair