BDBM50187261 (2R,5S)-1-(2-(1-(butoxymethyl)cyclopentylamino)acetyl)pyrrolidine-2,5-dicarbonitrile::CHEMBL209994

SMILES: CCCCOCC1(CCCC1)NCC(=O)N1[C@@H](CC[C@@H]1C#N)C#N

InChI Key: InChIKey=MAPHXEDRFCDTJT-IYBDPMFKSA-N

Data: 7 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50187261   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Fibroblast activation protein alpha (Homo sapiens (Human))	BDBM50187261 ((2R,5S)-1-(2-(1-(butoxymethyl)cyclopentylamino)ace...) Show SMILES CCCCOCC1(CCCC1)NCC(=O)N1[C@@H](CC[C@@H]1C#N)C#N Show InChI InChI=1S/C18H28N4O2/c1-2-3-10-24-14-18(8-4-5-9-18)21-13-17(23)22-15(11-19)6-7-16(22)12-20/h15-16,21H,2-10,13-14H2,1H3/t15-,16+	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>3.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Global Research and Development Curated by ChEMBL					Assay Description Inhibition of FAP				J Med Chem 49: 3068-76 (2006) Article DOI: 10.1021/jm0600085 BindingDB Entry DOI: 10.7270/Q2BG2NM7
					More data for this Ligand-Target Pair
Dipeptidyl peptidase 2 (DPP II) (Homo sapiens (Human))	BDBM50187261 ((2R,5S)-1-(2-(1-(butoxymethyl)cyclopentylamino)ace...) Show SMILES CCCCOCC1(CCCC1)NCC(=O)N1[C@@H](CC[C@@H]1C#N)C#N Show InChI InChI=1S/C18H28N4O2/c1-2-3-10-24-14-18(8-4-5-9-18)21-13-17(23)22-15(11-19)6-7-16(22)12-20/h15-16,21H,2-10,13-14H2,1H3/t15-,16+	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>3.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Global Research and Development Curated by ChEMBL					Assay Description Inhibition of DPP2				J Med Chem 49: 3068-76 (2006) Article DOI: 10.1021/jm0600085 BindingDB Entry DOI: 10.7270/Q2BG2NM7
					More data for this Ligand-Target Pair
Xaa-Pro aminopeptidase 1 (Homo sapiens (Human))	BDBM50187261 ((2R,5S)-1-(2-(1-(butoxymethyl)cyclopentylamino)ace...) Show SMILES CCCCOCC1(CCCC1)NCC(=O)N1[C@@H](CC[C@@H]1C#N)C#N Show InChI InChI=1S/C18H28N4O2/c1-2-3-10-24-14-18(8-4-5-9-18)21-13-17(23)22-15(11-19)6-7-16(22)12-20/h15-16,21H,2-10,13-14H2,1H3/t15-,16+	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>3.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Global Research and Development Curated by ChEMBL					Assay Description Inhibition of APP				J Med Chem 49: 3068-76 (2006) Article DOI: 10.1021/jm0600085 BindingDB Entry DOI: 10.7270/Q2BG2NM7
					More data for this Ligand-Target Pair
Dipeptidyl peptidase VIII (Homo sapiens (Human))	BDBM50187261 ((2R,5S)-1-(2-(1-(butoxymethyl)cyclopentylamino)ace...) Show SMILES CCCCOCC1(CCCC1)NCC(=O)N1[C@@H](CC[C@@H]1C#N)C#N Show InChI InChI=1S/C18H28N4O2/c1-2-3-10-24-14-18(8-4-5-9-18)21-13-17(23)22-15(11-19)6-7-16(22)12-20/h15-16,21H,2-10,13-14H2,1H3/t15-,16+	PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>3.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Global Research and Development Curated by ChEMBL					Assay Description Inhibition of DPP8				J Med Chem 49: 3068-76 (2006) Article DOI: 10.1021/jm0600085 BindingDB Entry DOI: 10.7270/Q2BG2NM7
					More data for this Ligand-Target Pair
Dipeptidyl peptidase 9 (Homo sapiens (Human))	BDBM50187261 ((2R,5S)-1-(2-(1-(butoxymethyl)cyclopentylamino)ace...) Show SMILES CCCCOCC1(CCCC1)NCC(=O)N1[C@@H](CC[C@@H]1C#N)C#N Show InChI InChI=1S/C18H28N4O2/c1-2-3-10-24-14-18(8-4-5-9-18)21-13-17(23)22-15(11-19)6-7-16(22)12-20/h15-16,21H,2-10,13-14H2,1H3/t15-,16+	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>3.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Global Research and Development Curated by ChEMBL					Assay Description Inhibition of DPP9				J Med Chem 49: 3068-76 (2006) Article DOI: 10.1021/jm0600085 BindingDB Entry DOI: 10.7270/Q2BG2NM7
					More data for this Ligand-Target Pair
Dipeptidyl peptidase 4 (Homo sapiens (Human))	BDBM50187261 ((2R,5S)-1-(2-(1-(butoxymethyl)cyclopentylamino)ace...) Show SMILES CCCCOCC1(CCCC1)NCC(=O)N1[C@@H](CC[C@@H]1C#N)C#N Show InChI InChI=1S/C18H28N4O2/c1-2-3-10-24-14-18(8-4-5-9-18)21-13-17(23)22-15(11-19)6-7-16(22)12-20/h15-16,21H,2-10,13-14H2,1H3/t15-,16+	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	91	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Global Research and Development Curated by ChEMBL					Assay Description Inhibition of human recombinant DPP4				J Med Chem 49: 3068-76 (2006) Article DOI: 10.1021/jm0600085 BindingDB Entry DOI: 10.7270/Q2BG2NM7
					More data for this Ligand-Target Pair
Dipeptidyl peptidase III (Homo sapiens (Human))	BDBM50187261 ((2R,5S)-1-(2-(1-(butoxymethyl)cyclopentylamino)ace...) Show SMILES CCCCOCC1(CCCC1)NCC(=O)N1[C@@H](CC[C@@H]1C#N)C#N Show InChI InChI=1S/C18H28N4O2/c1-2-3-10-24-14-18(8-4-5-9-18)21-13-17(23)22-15(11-19)6-7-16(22)12-20/h15-16,21H,2-10,13-14H2,1H3/t15-,16+	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>3.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Global Research and Development Curated by ChEMBL					Assay Description Inhibition of DPP3				J Med Chem 49: 3068-76 (2006) Article DOI: 10.1021/jm0600085 BindingDB Entry DOI: 10.7270/Q2BG2NM7
					More data for this Ligand-Target Pair