BindingDB PrimarySearch

BDBM50187266 (2R,5S)-1-(2-(1-(hydroxymethyl)cyclopentylamino)acetyl)pyrrolidine-2,5-dicarbonitrile::CHEMBL379522

SMILES: OCC1(CCCC1)NCC(=O)N1[C@@H](CC[C@@H]1C#N)C#N

InChI Key: InChIKey=VZOVKVCGZDERPK-TXEJJXNPSA-N

Data: 11 IC50

PDB links: 1 PDB ID matches this monomer.

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 11 hits for monomerid = 50187266
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Dipeptidyl peptidase 4 (Homo sapiens (Human))	BDBM50187266 ((2R,5S)-1-(2-(1-(hydroxymethyl)cyclopentylamino)ac...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	92	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Global Research and Development Curated by ChEMBL					Assay Description Inhibition of DPP4 in cynomolgus monkey plasma				J Med Chem 49: 3068-76 (2006) Article DOI: 10.1021/jm0600085 BindingDB Entry DOI: 10.7270/Q2BG2NM7
Pfizer Global Research and Development Curated by ChEMBL					More data for this Ligand-Target Pair
Dipeptidyl peptidase 4 (Homo sapiens (Human))	BDBM50187266 ((2R,5S)-1-(2-(1-(hydroxymethyl)cyclopentylamino)ac...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	109	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Global Research and Development Curated by ChEMBL					Assay Description Inhibition of DPP4 in beagle dog plasma				J Med Chem 49: 3068-76 (2006) Article DOI: 10.1021/jm0600085 BindingDB Entry DOI: 10.7270/Q2BG2NM7
Pfizer Global Research and Development Curated by ChEMBL					More data for this Ligand-Target Pair
Dipeptidyl peptidase 4 (Homo sapiens (Human))	BDBM50187266 ((2R,5S)-1-(2-(1-(hydroxymethyl)cyclopentylamino)ac...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	104	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Global Research and Development Curated by ChEMBL					Assay Description Inhibition of human recombinant DPP4				J Med Chem 49: 3068-76 (2006) Article DOI: 10.1021/jm0600085 BindingDB Entry DOI: 10.7270/Q2BG2NM7
Pfizer Global Research and Development Curated by ChEMBL					More data for this Ligand-Target Pair
Fibroblast activation protein alpha (Homo sapiens (Human))	BDBM50187266 ((2R,5S)-1-(2-(1-(hydroxymethyl)cyclopentylamino)ac...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	>3.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Global Research and Development Curated by ChEMBL					Assay Description Inhibition of FAP				J Med Chem 49: 3068-76 (2006) Article DOI: 10.1021/jm0600085 BindingDB Entry DOI: 10.7270/Q2BG2NM7
Pfizer Global Research and Development Curated by ChEMBL					More data for this Ligand-Target Pair
Dipeptidyl peptidase 9 (Homo sapiens (Human))	BDBM50187266 ((2R,5S)-1-(2-(1-(hydroxymethyl)cyclopentylamino)ac...) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	>3.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Global Research and Development Curated by ChEMBL					Assay Description Inhibition of DPP9				J Med Chem 49: 3068-76 (2006) Article DOI: 10.1021/jm0600085 BindingDB Entry DOI: 10.7270/Q2BG2NM7
Pfizer Global Research and Development Curated by ChEMBL					More data for this Ligand-Target Pair
Dipeptidyl peptidase III (Homo sapiens (Human))	BDBM50187266 ((2R,5S)-1-(2-(1-(hydroxymethyl)cyclopentylamino)ac...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	>3.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Global Research and Development Curated by ChEMBL					Assay Description Inhibition of DPP3				J Med Chem 49: 3068-76 (2006) Article DOI: 10.1021/jm0600085 BindingDB Entry DOI: 10.7270/Q2BG2NM7
Pfizer Global Research and Development Curated by ChEMBL					More data for this Ligand-Target Pair
Dipeptidyl peptidase 2 (DPP II) (Homo sapiens (Human))	BDBM50187266 ((2R,5S)-1-(2-(1-(hydroxymethyl)cyclopentylamino)ac...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	>3.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Global Research and Development Curated by ChEMBL					Assay Description Inhibition of DPP2				J Med Chem 49: 3068-76 (2006) Article DOI: 10.1021/jm0600085 BindingDB Entry DOI: 10.7270/Q2BG2NM7
Pfizer Global Research and Development Curated by ChEMBL					More data for this Ligand-Target Pair
Xaa-Pro aminopeptidase 1 (Homo sapiens (Human))	BDBM50187266 ((2R,5S)-1-(2-(1-(hydroxymethyl)cyclopentylamino)ac...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	>3.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Global Research and Development Curated by ChEMBL					Assay Description Inhibition of APP				J Med Chem 49: 3068-76 (2006) Article DOI: 10.1021/jm0600085 BindingDB Entry DOI: 10.7270/Q2BG2NM7
Pfizer Global Research and Development Curated by ChEMBL					More data for this Ligand-Target Pair
Dipeptidyl peptidase VIII (Homo sapiens (Human))	BDBM50187266 ((2R,5S)-1-(2-(1-(hydroxymethyl)cyclopentylamino)ac...) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	>3.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Global Research and Development Curated by ChEMBL					Assay Description Inhibition of DPP8				J Med Chem 49: 3068-76 (2006) Article DOI: 10.1021/jm0600085 BindingDB Entry DOI: 10.7270/Q2BG2NM7
Pfizer Global Research and Development Curated by ChEMBL					More data for this Ligand-Target Pair
Dipeptidyl peptidase 4 (Homo sapiens (Human))	BDBM50187266 ((2R,5S)-1-(2-(1-(hydroxymethyl)cyclopentylamino)ac...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	69	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Global Research and Development Curated by ChEMBL					Assay Description Inhibition of DPP4 in beagle dog plasma				J Med Chem 49: 3068-76 (2006) Article DOI: 10.1021/jm0600085 BindingDB Entry DOI: 10.7270/Q2BG2NM7
Pfizer Global Research and Development Curated by ChEMBL					More data for this Ligand-Target Pair
Dipeptidyl peptidase IV (Rattus norvegicus (rat))	BDBM50187266 ((2R,5S)-1-(2-(1-(hydroxymethyl)cyclopentylamino)ac...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	38	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Global Research and Development Curated by ChEMBL					Assay Description Inhibition of DPP4 in Sprague-Dawley rat plasma				J Med Chem 49: 3068-76 (2006) Article DOI: 10.1021/jm0600085 BindingDB Entry DOI: 10.7270/Q2BG2NM7
Pfizer Global Research and Development Curated by ChEMBL					More data for this Ligand-Target Pair