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Enter Data

BDBM50187345 (5-Hydroxy-1H-indol-2-yl)-(4-methyl-1H-indol-2-yl)-methanone::CHEMBL207858

SMILES: Cc1cccc2[nH]c(cc12)C(=O)c1cc2cc(O)ccc2[nH]1

InChI Key: InChIKey=QNNCAUNEIPNZAQ-UHFFFAOYSA-N

Data: 6 IC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50187345
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Platelet-derived growth factor receptor beta (Homo sapiens (Human))	BDBM50187345 ((5-Hydroxy-1H-indol-2-yl)-(4-methyl-1H-indol-2-yl)...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	458	n/a	n/a	n/a	n/a	n/a	n/a
University of Regensburg Curated by ChEMBL					Assay Description Inhibition of human PDGFR beta				J Med Chem 49: 3101-15 (2006) Article DOI: 10.1021/jm058033i BindingDB Entry DOI: 10.7270/Q26T0M7B
University of Regensburg Curated by ChEMBL					More data for this Ligand-Target Pair
Mast/stem cell growth factor receptor Kit (Homo sapiens (Human))	BDBM50187345 ((5-Hydroxy-1H-indol-2-yl)-(4-methyl-1H-indol-2-yl)...) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	500	n/a	n/a	n/a	n/a	n/a	n/a
University of Regensburg Curated by ChEMBL					Assay Description Inhibition of DNA synthesis in IL3 dependent FDC-P1 cells expressing wildtype KIT				J Med Chem 49: 3101-15 (2006) Article DOI: 10.1021/jm058033i BindingDB Entry DOI: 10.7270/Q26T0M7B
University of Regensburg Curated by ChEMBL					More data for this Ligand-Target Pair
Receptor-type tyrosine-protein kinase FLT3 (Homo sapiens (Human))	BDBM50187345 ((5-Hydroxy-1H-indol-2-yl)-(4-methyl-1H-indol-2-yl)...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	60	n/a	n/a	n/a	n/a	n/a	n/a
University of Regensburg Curated by ChEMBL					Assay Description Inhibition of endogenous FLT3 in EOL1 cells				J Med Chem 49: 3101-15 (2006) Article DOI: 10.1021/jm058033i BindingDB Entry DOI: 10.7270/Q26T0M7B
University of Regensburg Curated by ChEMBL					More data for this Ligand-Target Pair
PDGFR-beta/Platelet-derived growth factor receptor alpha (Mus musculus (mouse))	BDBM50187345 ((5-Hydroxy-1H-indol-2-yl)-(4-methyl-1H-indol-2-yl)...) Show SMILES Show InChI	MMDB KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	960	n/a	n/a	n/a	n/a	n/a	n/a
University of Regensburg Curated by ChEMBL					Assay Description Inhibition of endogenous PDGFR in Swiss3T3 fibroblasts				J Med Chem 49: 3101-15 (2006) Article DOI: 10.1021/jm058033i BindingDB Entry DOI: 10.7270/Q26T0M7B
University of Regensburg Curated by ChEMBL					More data for this Ligand-Target Pair
Receptor-type tyrosine-protein kinase FLT3 (Homo sapiens (Human))	BDBM50187345 ((5-Hydroxy-1H-indol-2-yl)-(4-methyl-1H-indol-2-yl)...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	70	n/a	n/a	n/a	n/a	n/a	n/a
University of Regensburg Curated by ChEMBL					Assay Description Inhibition of human FLT3				J Med Chem 49: 3101-15 (2006) Article DOI: 10.1021/jm058033i BindingDB Entry DOI: 10.7270/Q26T0M7B
University of Regensburg Curated by ChEMBL					More data for this Ligand-Target Pair
Mast/stem cell growth factor receptor Kit (Homo sapiens (Human))	BDBM50187345 ((5-Hydroxy-1H-indol-2-yl)-(4-methyl-1H-indol-2-yl)...) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	500	n/a	n/a	n/a	n/a	n/a	n/a
University of Regensburg Curated by ChEMBL					Assay Description Inhibition of DNA synthesis in IL3 dependent FDC-P1 cells expressing KIT V558D mutant				J Med Chem 49: 3101-15 (2006) Article DOI: 10.1021/jm058033i BindingDB Entry DOI: 10.7270/Q26T0M7B
University of Regensburg Curated by ChEMBL					More data for this Ligand-Target Pair