Found 34 hits for monomerid = 50187377 Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
5-hydroxytryptamine receptor 1A
(Homo sapiens (Human)) | BDBM50187377
(CHEMBL209821 | N-(3-(4-(4-(cyclohexylmethylsulfona...)Show SMILES CC(=O)Nc1cccc(c1)N1CCN(CCCCNS(=O)(=O)CC2CCCCC2)CC1 Show InChI InChI=1S/C23H38N4O3S/c1-20(28)25-22-10-7-11-23(18-22)27-16-14-26(15-17-27)13-6-5-12-24-31(29,30)19-21-8-3-2-4-9-21/h7,10-11,18,21,24H,2-6,8-9,12-17,19H2,1H3,(H,25,28) | PDB
UniProtKB/SwissProt UniProtKB/TrEMBL
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| Article PubMed
| 5.10 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Predix Pharmaceuticals Ltd.
Curated by ChEMBL
| Assay Description Displacement of [3H]8-OH-DPAT from human 5HT1A receptor in HEK293 cells |
J Med Chem 49: 3116-35 (2006)
Article DOI: 10.1021/jm0508641 BindingDB Entry DOI: 10.7270/Q2319VHC |
More data for this Ligand-Target Pair | |
5-hydroxytryptamine receptor 1A
(Rattus norvegicus (rat)) | BDBM50187377
(CHEMBL209821 | N-(3-(4-(4-(cyclohexylmethylsulfona...)Show SMILES CC(=O)Nc1cccc(c1)N1CCN(CCCCNS(=O)(=O)CC2CCCCC2)CC1 Show InChI InChI=1S/C23H38N4O3S/c1-20(28)25-22-10-7-11-23(18-22)27-16-14-26(15-17-27)13-6-5-12-24-31(29,30)19-21-8-3-2-4-9-21/h7,10-11,18,21,24H,2-6,8-9,12-17,19H2,1H3,(H,25,28) | PDB
KEGG
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| Article PubMed
| 17 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Predix Pharmaceuticals Ltd.
Curated by ChEMBL
| Assay Description Binding affinity to 5HT1A receptor in rat cerebral cortex by radioligand binding assay |
J Med Chem 49: 3116-35 (2006)
Article DOI: 10.1021/jm0508641 BindingDB Entry DOI: 10.7270/Q2319VHC |
More data for this Ligand-Target Pair | |
5-hydroxytryptamine receptor 1A
(Rattus norvegicus (rat)) | BDBM50187377
(CHEMBL209821 | N-(3-(4-(4-(cyclohexylmethylsulfona...)Show SMILES CC(=O)Nc1cccc(c1)N1CCN(CCCCNS(=O)(=O)CC2CCCCC2)CC1 Show InChI InChI=1S/C23H38N4O3S/c1-20(28)25-22-10-7-11-23(18-22)27-16-14-26(15-17-27)13-6-5-12-24-31(29,30)19-21-8-3-2-4-9-21/h7,10-11,18,21,24H,2-6,8-9,12-17,19H2,1H3,(H,25,28) | PDB
KEGG
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| 30 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pierre Fabre Research Center
Curated by ChEMBL
| Assay Description Binding affinity to 5HT1A receptor in rat cortex membrane |
J Med Chem 50: 5024-33 (2007)
Article DOI: 10.1021/jm070714l BindingDB Entry DOI: 10.7270/Q2HH6NTB |
More data for this Ligand-Target Pair | |
Sigma non-opioid intracellular receptor 1
(Homo sapiens (Human)) | BDBM50187377
(CHEMBL209821 | N-(3-(4-(4-(cyclohexylmethylsulfona...)Show SMILES CC(=O)Nc1cccc(c1)N1CCN(CCCCNS(=O)(=O)CC2CCCCC2)CC1 Show InChI InChI=1S/C23H38N4O3S/c1-20(28)25-22-10-7-11-23(18-22)27-16-14-26(15-17-27)13-6-5-12-24-31(29,30)19-21-8-3-2-4-9-21/h7,10-11,18,21,24H,2-6,8-9,12-17,19H2,1H3,(H,25,28) | PDB
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| Article PubMed
| 100 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Predix Pharmaceuticals Ltd.
Curated by ChEMBL
| Assay Description Binding affinity to guinea pig sigma receptor by radioligand binding assay |
J Med Chem 49: 3116-35 (2006)
Article DOI: 10.1021/jm0508641 BindingDB Entry DOI: 10.7270/Q2319VHC |
More data for this Ligand-Target Pair | |
5-hydroxytryptamine receptor 7
(Homo sapiens (Human)) | BDBM50187377
(CHEMBL209821 | N-(3-(4-(4-(cyclohexylmethylsulfona...)Show SMILES CC(=O)Nc1cccc(c1)N1CCN(CCCCNS(=O)(=O)CC2CCCCC2)CC1 Show InChI InChI=1S/C23H38N4O3S/c1-20(28)25-22-10-7-11-23(18-22)27-16-14-26(15-17-27)13-6-5-12-24-31(29,30)19-21-8-3-2-4-9-21/h7,10-11,18,21,24H,2-6,8-9,12-17,19H2,1H3,(H,25,28) | Reactome pathway KEGG
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| Article PubMed
| 700 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Predix Pharmaceuticals Ltd.
Curated by ChEMBL
| Assay Description Binding affinity to 5HT7 receptor by radioligand binding assay |
J Med Chem 49: 3116-35 (2006)
Article DOI: 10.1021/jm0508641 BindingDB Entry DOI: 10.7270/Q2319VHC |
More data for this Ligand-Target Pair | |
Alpha-1 Adrenergic Receptor/ adrenergic receptor/ adrenergic receptor
(Rattus norvegicus (rat)-Rattus norvegicus (Rat)) | BDBM50187377
(CHEMBL209821 | N-(3-(4-(4-(cyclohexylmethylsulfona...)Show SMILES CC(=O)Nc1cccc(c1)N1CCN(CCCCNS(=O)(=O)CC2CCCCC2)CC1 Show InChI InChI=1S/C23H38N4O3S/c1-20(28)25-22-10-7-11-23(18-22)27-16-14-26(15-17-27)13-6-5-12-24-31(29,30)19-21-8-3-2-4-9-21/h7,10-11,18,21,24H,2-6,8-9,12-17,19H2,1H3,(H,25,28) | Reactome pathway KEGG
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| 1.60E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Predix Pharmaceuticals Ltd.
Curated by ChEMBL
| Assay Description Displacement of [3H]prazosin from adrenergic alpha-1 receptor in rat cerebral cortex cells |
J Med Chem 49: 3116-35 (2006)
Article DOI: 10.1021/jm0508641 BindingDB Entry DOI: 10.7270/Q2319VHC |
More data for this Ligand-Target Pair | |
Potassium voltage-gated channel subfamily H member 2
(Homo sapiens (Human)) | BDBM50187377
(CHEMBL209821 | N-(3-(4-(4-(cyclohexylmethylsulfona...)Show SMILES CC(=O)Nc1cccc(c1)N1CCN(CCCCNS(=O)(=O)CC2CCCCC2)CC1 Show InChI InChI=1S/C23H38N4O3S/c1-20(28)25-22-10-7-11-23(18-22)27-16-14-26(15-17-27)13-6-5-12-24-31(29,30)19-21-8-3-2-4-9-21/h7,10-11,18,21,24H,2-6,8-9,12-17,19H2,1H3,(H,25,28) | PDB MMDB
Reactome pathway KEGG
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| Article PubMed
| >2.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Predix Pharmaceuticals Ltd.
Curated by ChEMBL
| Assay Description Binding affinity to potassium channel by radioligand binding assay |
J Med Chem 49: 3116-35 (2006)
Article DOI: 10.1021/jm0508641 BindingDB Entry DOI: 10.7270/Q2319VHC |
More data for this Ligand-Target Pair | |
Cholecystokinin receptor
(Homo sapiens (Human)) | BDBM50187377
(CHEMBL209821 | N-(3-(4-(4-(cyclohexylmethylsulfona...)Show SMILES CC(=O)Nc1cccc(c1)N1CCN(CCCCNS(=O)(=O)CC2CCCCC2)CC1 Show InChI InChI=1S/C23H38N4O3S/c1-20(28)25-22-10-7-11-23(18-22)27-16-14-26(15-17-27)13-6-5-12-24-31(29,30)19-21-8-3-2-4-9-21/h7,10-11,18,21,24H,2-6,8-9,12-17,19H2,1H3,(H,25,28) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
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| Article PubMed
| >2.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Predix Pharmaceuticals Ltd.
Curated by ChEMBL
| Assay Description Binding affinity to cholecystokinin receptor by radioligand binding assay |
J Med Chem 49: 3116-35 (2006)
Article DOI: 10.1021/jm0508641 BindingDB Entry DOI: 10.7270/Q2319VHC |
More data for this Ligand-Target Pair | |
Somatostatin receptor
(Homo sapiens (Human)) | BDBM50187377
(CHEMBL209821 | N-(3-(4-(4-(cyclohexylmethylsulfona...)Show SMILES CC(=O)Nc1cccc(c1)N1CCN(CCCCNS(=O)(=O)CC2CCCCC2)CC1 Show InChI InChI=1S/C23H38N4O3S/c1-20(28)25-22-10-7-11-23(18-22)27-16-14-26(15-17-27)13-6-5-12-24-31(29,30)19-21-8-3-2-4-9-21/h7,10-11,18,21,24H,2-6,8-9,12-17,19H2,1H3,(H,25,28) | KEGG
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| Article PubMed
| >2.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Predix Pharmaceuticals Ltd.
Curated by ChEMBL
| Assay Description Binding affinity to somatostatin receptor by radioligand binding assay |
J Med Chem 49: 3116-35 (2006)
Article DOI: 10.1021/jm0508641 BindingDB Entry DOI: 10.7270/Q2319VHC |
More data for this Ligand-Target Pair | |
Nociceptin receptor
(Homo sapiens (Human)) | BDBM50187377
(CHEMBL209821 | N-(3-(4-(4-(cyclohexylmethylsulfona...)Show SMILES CC(=O)Nc1cccc(c1)N1CCN(CCCCNS(=O)(=O)CC2CCCCC2)CC1 Show InChI InChI=1S/C23H38N4O3S/c1-20(28)25-22-10-7-11-23(18-22)27-16-14-26(15-17-27)13-6-5-12-24-31(29,30)19-21-8-3-2-4-9-21/h7,10-11,18,21,24H,2-6,8-9,12-17,19H2,1H3,(H,25,28) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
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| Article PubMed
| >2.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Predix Pharmaceuticals Ltd.
Curated by ChEMBL
| Assay Description Binding affinity to orphanin receptor by radioligand binding assay |
J Med Chem 49: 3116-35 (2006)
Article DOI: 10.1021/jm0508641 BindingDB Entry DOI: 10.7270/Q2319VHC |
More data for this Ligand-Target Pair | |
D(2) dopamine receptor
(Homo sapiens (Human)) | BDBM50187377
(CHEMBL209821 | N-(3-(4-(4-(cyclohexylmethylsulfona...)Show SMILES CC(=O)Nc1cccc(c1)N1CCN(CCCCNS(=O)(=O)CC2CCCCC2)CC1 Show InChI InChI=1S/C23H38N4O3S/c1-20(28)25-22-10-7-11-23(18-22)27-16-14-26(15-17-27)13-6-5-12-24-31(29,30)19-21-8-3-2-4-9-21/h7,10-11,18,21,24H,2-6,8-9,12-17,19H2,1H3,(H,25,28) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt UniProtKB/TrEMBL
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| Article PubMed
| >2.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Predix Pharmaceuticals Ltd.
Curated by ChEMBL
| Assay Description Binding affinity to D2 receptor by radioligand binding assay |
J Med Chem 49: 3116-35 (2006)
Article DOI: 10.1021/jm0508641 BindingDB Entry DOI: 10.7270/Q2319VHC |
More data for this Ligand-Target Pair | |
Sodium-dependent dopamine transporter
(Homo sapiens (Human)) | BDBM50187377
(CHEMBL209821 | N-(3-(4-(4-(cyclohexylmethylsulfona...)Show SMILES CC(=O)Nc1cccc(c1)N1CCN(CCCCNS(=O)(=O)CC2CCCCC2)CC1 Show InChI InChI=1S/C23H38N4O3S/c1-20(28)25-22-10-7-11-23(18-22)27-16-14-26(15-17-27)13-6-5-12-24-31(29,30)19-21-8-3-2-4-9-21/h7,10-11,18,21,24H,2-6,8-9,12-17,19H2,1H3,(H,25,28) | NCI pathway Reactome pathway KEGG
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| Article PubMed
| >2.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Predix Pharmaceuticals Ltd.
Curated by ChEMBL
| Assay Description Binding affinity to dopamine transporter by radioligand binding assay |
J Med Chem 49: 3116-35 (2006)
Article DOI: 10.1021/jm0508641 BindingDB Entry DOI: 10.7270/Q2319VHC |
More data for this Ligand-Target Pair | |
Serotonin 1B/1D receptor
(Rattus norvegicus (Rat)) | BDBM50187377
(CHEMBL209821 | N-(3-(4-(4-(cyclohexylmethylsulfona...)Show SMILES CC(=O)Nc1cccc(c1)N1CCN(CCCCNS(=O)(=O)CC2CCCCC2)CC1 Show InChI InChI=1S/C23H38N4O3S/c1-20(28)25-22-10-7-11-23(18-22)27-16-14-26(15-17-27)13-6-5-12-24-31(29,30)19-21-8-3-2-4-9-21/h7,10-11,18,21,24H,2-6,8-9,12-17,19H2,1H3,(H,25,28) | PDB
Reactome pathway KEGG
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| Article PubMed
| >2.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Predix Pharmaceuticals Ltd.
Curated by ChEMBL
| Assay Description Binding affinity to 5HT1B receptor in rat cerebral cortex by radioligand binding assay |
J Med Chem 49: 3116-35 (2006)
Article DOI: 10.1021/jm0508641 BindingDB Entry DOI: 10.7270/Q2319VHC |
More data for this Ligand-Target Pair | |
Adrenergic receptor beta
(Homo sapiens (Human)) | BDBM50187377
(CHEMBL209821 | N-(3-(4-(4-(cyclohexylmethylsulfona...)Show SMILES CC(=O)Nc1cccc(c1)N1CCN(CCCCNS(=O)(=O)CC2CCCCC2)CC1 Show InChI InChI=1S/C23H38N4O3S/c1-20(28)25-22-10-7-11-23(18-22)27-16-14-26(15-17-27)13-6-5-12-24-31(29,30)19-21-8-3-2-4-9-21/h7,10-11,18,21,24H,2-6,8-9,12-17,19H2,1H3,(H,25,28) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt UniProtKB/TrEMBL
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Patents
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| Article PubMed
| >2.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Predix Pharmaceuticals Ltd.
Curated by ChEMBL
| Assay Description Binding affinity to beta adrenergic receptor by radioligand binding assay |
J Med Chem 49: 3116-35 (2006)
Article DOI: 10.1021/jm0508641 BindingDB Entry DOI: 10.7270/Q2319VHC |
More data for this Ligand-Target Pair | |
Angiotensin II receptor
(Homo sapiens (Human)) | BDBM50187377
(CHEMBL209821 | N-(3-(4-(4-(cyclohexylmethylsulfona...)Show SMILES CC(=O)Nc1cccc(c1)N1CCN(CCCCNS(=O)(=O)CC2CCCCC2)CC1 Show InChI InChI=1S/C23H38N4O3S/c1-20(28)25-22-10-7-11-23(18-22)27-16-14-26(15-17-27)13-6-5-12-24-31(29,30)19-21-8-3-2-4-9-21/h7,10-11,18,21,24H,2-6,8-9,12-17,19H2,1H3,(H,25,28) | PDB
Reactome pathway KEGG
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| Article PubMed
| >2.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Predix Pharmaceuticals Ltd.
Curated by ChEMBL
| Assay Description Binding affinity to angiotensin2 receptor by radioligand binding assay |
J Med Chem 49: 3116-35 (2006)
Article DOI: 10.1021/jm0508641 BindingDB Entry DOI: 10.7270/Q2319VHC |
More data for this Ligand-Target Pair | |
Dopamine receptor
(Homo sapiens (Human)) | BDBM50187377
(CHEMBL209821 | N-(3-(4-(4-(cyclohexylmethylsulfona...)Show SMILES CC(=O)Nc1cccc(c1)N1CCN(CCCCNS(=O)(=O)CC2CCCCC2)CC1 Show InChI InChI=1S/C23H38N4O3S/c1-20(28)25-22-10-7-11-23(18-22)27-16-14-26(15-17-27)13-6-5-12-24-31(29,30)19-21-8-3-2-4-9-21/h7,10-11,18,21,24H,2-6,8-9,12-17,19H2,1H3,(H,25,28) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt UniProtKB/TrEMBL
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Patents
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| Article PubMed
| >2.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Predix Pharmaceuticals Ltd.
Curated by ChEMBL
| Assay Description Binding affinity to dopamine receptor by radioligand binding assay |
J Med Chem 49: 3116-35 (2006)
Article DOI: 10.1021/jm0508641 BindingDB Entry DOI: 10.7270/Q2319VHC |
More data for this Ligand-Target Pair | |
Muscarinic acetylcholine receptor
(Homo sapiens (Human)) | BDBM50187377
(CHEMBL209821 | N-(3-(4-(4-(cyclohexylmethylsulfona...)Show SMILES CC(=O)Nc1cccc(c1)N1CCN(CCCCNS(=O)(=O)CC2CCCCC2)CC1 Show InChI InChI=1S/C23H38N4O3S/c1-20(28)25-22-10-7-11-23(18-22)27-16-14-26(15-17-27)13-6-5-12-24-31(29,30)19-21-8-3-2-4-9-21/h7,10-11,18,21,24H,2-6,8-9,12-17,19H2,1H3,(H,25,28) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt UniProtKB/TrEMBL
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CHEMBL PC cid PC sid UniChem
Patents
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| Article PubMed
| >2.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Predix Pharmaceuticals Ltd.
Curated by ChEMBL
| Assay Description Binding affinity to muscarinic receptor by radioligand binding assay |
J Med Chem 49: 3116-35 (2006)
Article DOI: 10.1021/jm0508641 BindingDB Entry DOI: 10.7270/Q2319VHC |
More data for this Ligand-Target Pair | |
Opioid receptors; mu/kappa/delta
(Homo sapiens (Human)) | BDBM50187377
(CHEMBL209821 | N-(3-(4-(4-(cyclohexylmethylsulfona...)Show SMILES CC(=O)Nc1cccc(c1)N1CCN(CCCCNS(=O)(=O)CC2CCCCC2)CC1 Show InChI InChI=1S/C23H38N4O3S/c1-20(28)25-22-10-7-11-23(18-22)27-16-14-26(15-17-27)13-6-5-12-24-31(29,30)19-21-8-3-2-4-9-21/h7,10-11,18,21,24H,2-6,8-9,12-17,19H2,1H3,(H,25,28) | PDB
UniProtKB/SwissProt
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CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| >2.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Predix Pharmaceuticals Ltd.
Curated by ChEMBL
| Assay Description Binding affinity to opioid receptor by radioligand binding assay |
J Med Chem 49: 3116-35 (2006)
Article DOI: 10.1021/jm0508641 BindingDB Entry DOI: 10.7270/Q2319VHC |
More data for this Ligand-Target Pair | |
Translocator protein
(Homo sapiens (Human)) | BDBM50187377
(CHEMBL209821 | N-(3-(4-(4-(cyclohexylmethylsulfona...)Show SMILES CC(=O)Nc1cccc(c1)N1CCN(CCCCNS(=O)(=O)CC2CCCCC2)CC1 Show InChI InChI=1S/C23H38N4O3S/c1-20(28)25-22-10-7-11-23(18-22)27-16-14-26(15-17-27)13-6-5-12-24-31(29,30)19-21-8-3-2-4-9-21/h7,10-11,18,21,24H,2-6,8-9,12-17,19H2,1H3,(H,25,28) | KEGG
UniProtKB/SwissProt
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CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| >2.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Predix Pharmaceuticals Ltd.
Curated by ChEMBL
| Assay Description Binding affinity to benzodiazepine receptor by radioligand binding assay |
J Med Chem 49: 3116-35 (2006)
Article DOI: 10.1021/jm0508641 BindingDB Entry DOI: 10.7270/Q2319VHC |
More data for this Ligand-Target Pair | |
Endothelin receptor, ET-A/ET-B
(Homo sapiens (Human)) | BDBM50187377
(CHEMBL209821 | N-(3-(4-(4-(cyclohexylmethylsulfona...)Show SMILES CC(=O)Nc1cccc(c1)N1CCN(CCCCNS(=O)(=O)CC2CCCCC2)CC1 Show InChI InChI=1S/C23H38N4O3S/c1-20(28)25-22-10-7-11-23(18-22)27-16-14-26(15-17-27)13-6-5-12-24-31(29,30)19-21-8-3-2-4-9-21/h7,10-11,18,21,24H,2-6,8-9,12-17,19H2,1H3,(H,25,28) | PDB
KEGG
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| >2.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Predix Pharmaceuticals Ltd.
Curated by ChEMBL
| Assay Description Binding affinity to endothelin receptor by radioligand binding assay |
J Med Chem 49: 3116-35 (2006)
Article DOI: 10.1021/jm0508641 BindingDB Entry DOI: 10.7270/Q2319VHC |
More data for this Ligand-Target Pair | |
5-hydroxytryptamine receptor 2A
(Homo sapiens (Human)) | BDBM50187377
(CHEMBL209821 | N-(3-(4-(4-(cyclohexylmethylsulfona...)Show SMILES CC(=O)Nc1cccc(c1)N1CCN(CCCCNS(=O)(=O)CC2CCCCC2)CC1 Show InChI InChI=1S/C23H38N4O3S/c1-20(28)25-22-10-7-11-23(18-22)27-16-14-26(15-17-27)13-6-5-12-24-31(29,30)19-21-8-3-2-4-9-21/h7,10-11,18,21,24H,2-6,8-9,12-17,19H2,1H3,(H,25,28) | PDB MMDB
Reactome pathway KEGG
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| Article PubMed
| >2.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Predix Pharmaceuticals Ltd.
Curated by ChEMBL
| Assay Description Binding affinity to 5HT2A receptor by radioligand binding assay |
J Med Chem 49: 3116-35 (2006)
Article DOI: 10.1021/jm0508641 BindingDB Entry DOI: 10.7270/Q2319VHC |
More data for this Ligand-Target Pair | |
Sigma non-opioid intracellular receptor 1
(Homo sapiens (Human)) | BDBM50187377
(CHEMBL209821 | N-(3-(4-(4-(cyclohexylmethylsulfona...)Show SMILES CC(=O)Nc1cccc(c1)N1CCN(CCCCNS(=O)(=O)CC2CCCCC2)CC1 Show InChI InChI=1S/C23H38N4O3S/c1-20(28)25-22-10-7-11-23(18-22)27-16-14-26(15-17-27)13-6-5-12-24-31(29,30)19-21-8-3-2-4-9-21/h7,10-11,18,21,24H,2-6,8-9,12-17,19H2,1H3,(H,25,28) | PDB
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| >2.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Predix Pharmaceuticals Ltd.
Curated by ChEMBL
| Assay Description Binding affinity to sigma receptor by radioligand binding assay |
J Med Chem 49: 3116-35 (2006)
Article DOI: 10.1021/jm0508641 BindingDB Entry DOI: 10.7270/Q2319VHC |
More data for this Ligand-Target Pair | |
Sodium-dependent noradrenaline transporter
(Homo sapiens (Human)) | BDBM50187377
(CHEMBL209821 | N-(3-(4-(4-(cyclohexylmethylsulfona...)Show SMILES CC(=O)Nc1cccc(c1)N1CCN(CCCCNS(=O)(=O)CC2CCCCC2)CC1 Show InChI InChI=1S/C23H38N4O3S/c1-20(28)25-22-10-7-11-23(18-22)27-16-14-26(15-17-27)13-6-5-12-24-31(29,30)19-21-8-3-2-4-9-21/h7,10-11,18,21,24H,2-6,8-9,12-17,19H2,1H3,(H,25,28) | Reactome pathway KEGG
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| >2.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Predix Pharmaceuticals Ltd.
Curated by ChEMBL
| Assay Description Binding affinity to norepinephrine transporter by radioligand binding assay |
J Med Chem 49: 3116-35 (2006)
Article DOI: 10.1021/jm0508641 BindingDB Entry DOI: 10.7270/Q2319VHC |
More data for this Ligand-Target Pair | |
5-hydroxytryptamine receptor 1D
(Homo sapiens (Human)) | BDBM50187377
(CHEMBL209821 | N-(3-(4-(4-(cyclohexylmethylsulfona...)Show SMILES CC(=O)Nc1cccc(c1)N1CCN(CCCCNS(=O)(=O)CC2CCCCC2)CC1 Show InChI InChI=1S/C23H38N4O3S/c1-20(28)25-22-10-7-11-23(18-22)27-16-14-26(15-17-27)13-6-5-12-24-31(29,30)19-21-8-3-2-4-9-21/h7,10-11,18,21,24H,2-6,8-9,12-17,19H2,1H3,(H,25,28) | PDB
Reactome pathway KEGG
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| >2.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Predix Pharmaceuticals Ltd.
Curated by ChEMBL
| Assay Description Binding affinity to bovine 5HT1D receptor by radioligand binding assay |
J Med Chem 49: 3116-35 (2006)
Article DOI: 10.1021/jm0508641 BindingDB Entry DOI: 10.7270/Q2319VHC |
More data for this Ligand-Target Pair | |
5-hydroxytryptamine receptor 4 (5-HT4)
(Homo sapiens (Human)) | BDBM50187377
(CHEMBL209821 | N-(3-(4-(4-(cyclohexylmethylsulfona...)Show SMILES CC(=O)Nc1cccc(c1)N1CCN(CCCCNS(=O)(=O)CC2CCCCC2)CC1 Show InChI InChI=1S/C23H38N4O3S/c1-20(28)25-22-10-7-11-23(18-22)27-16-14-26(15-17-27)13-6-5-12-24-31(29,30)19-21-8-3-2-4-9-21/h7,10-11,18,21,24H,2-6,8-9,12-17,19H2,1H3,(H,25,28) | UniProtKB/SwissProt UniProtKB/TrEMBL
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| >5.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Predix Pharmaceuticals Ltd.
Curated by ChEMBL
| Assay Description Binding affinity to human 5HT4e receptor by radioligand binding assay |
J Med Chem 49: 3116-35 (2006)
Article DOI: 10.1021/jm0508641 BindingDB Entry DOI: 10.7270/Q2319VHC |
More data for this Ligand-Target Pair | |
5-hydroxytryptamine receptor 5A
(Homo sapiens (Human)) | BDBM50187377
(CHEMBL209821 | N-(3-(4-(4-(cyclohexylmethylsulfona...)Show SMILES CC(=O)Nc1cccc(c1)N1CCN(CCCCNS(=O)(=O)CC2CCCCC2)CC1 Show InChI InChI=1S/C23H38N4O3S/c1-20(28)25-22-10-7-11-23(18-22)27-16-14-26(15-17-27)13-6-5-12-24-31(29,30)19-21-8-3-2-4-9-21/h7,10-11,18,21,24H,2-6,8-9,12-17,19H2,1H3,(H,25,28) | KEGG
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CHEMBL PC cid PC sid UniChem
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| Article PubMed
| >5.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Predix Pharmaceuticals Ltd.
Curated by ChEMBL
| Assay Description Binding affinity to human 5HT5A receptor by radioligand binding assay |
J Med Chem 49: 3116-35 (2006)
Article DOI: 10.1021/jm0508641 BindingDB Entry DOI: 10.7270/Q2319VHC |
More data for this Ligand-Target Pair | |
5-hydroxytryptamine receptor 2C
(Homo sapiens (Human)) | BDBM50187377
(CHEMBL209821 | N-(3-(4-(4-(cyclohexylmethylsulfona...)Show SMILES CC(=O)Nc1cccc(c1)N1CCN(CCCCNS(=O)(=O)CC2CCCCC2)CC1 Show InChI InChI=1S/C23H38N4O3S/c1-20(28)25-22-10-7-11-23(18-22)27-16-14-26(15-17-27)13-6-5-12-24-31(29,30)19-21-8-3-2-4-9-21/h7,10-11,18,21,24H,2-6,8-9,12-17,19H2,1H3,(H,25,28) | Reactome pathway KEGG
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| Article PubMed
| >5.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Predix Pharmaceuticals Ltd.
Curated by ChEMBL
| Assay Description Binding affinity to human 5HT2C receptor by radioligand binding assay |
J Med Chem 49: 3116-35 (2006)
Article DOI: 10.1021/jm0508641 BindingDB Entry DOI: 10.7270/Q2319VHC |
More data for this Ligand-Target Pair | |
Serotonin 3 receptor (5HT3)
(Mus musculus (house mouse)) | BDBM50187377
(CHEMBL209821 | N-(3-(4-(4-(cyclohexylmethylsulfona...)Show SMILES CC(=O)Nc1cccc(c1)N1CCN(CCCCNS(=O)(=O)CC2CCCCC2)CC1 Show InChI InChI=1S/C23H38N4O3S/c1-20(28)25-22-10-7-11-23(18-22)27-16-14-26(15-17-27)13-6-5-12-24-31(29,30)19-21-8-3-2-4-9-21/h7,10-11,18,21,24H,2-6,8-9,12-17,19H2,1H3,(H,25,28) | PDB
Reactome pathway KEGG
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| Article PubMed
| >5.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Predix Pharmaceuticals Ltd.
Curated by ChEMBL
| Assay Description Binding affinity to mouse 5HT3 receptor by radioligand binding assay |
J Med Chem 49: 3116-35 (2006)
Article DOI: 10.1021/jm0508641 BindingDB Entry DOI: 10.7270/Q2319VHC |
More data for this Ligand-Target Pair | |
5-hydroxytryptamine receptor 6
(Homo sapiens (Human)) | BDBM50187377
(CHEMBL209821 | N-(3-(4-(4-(cyclohexylmethylsulfona...)Show SMILES CC(=O)Nc1cccc(c1)N1CCN(CCCCNS(=O)(=O)CC2CCCCC2)CC1 Show InChI InChI=1S/C23H38N4O3S/c1-20(28)25-22-10-7-11-23(18-22)27-16-14-26(15-17-27)13-6-5-12-24-31(29,30)19-21-8-3-2-4-9-21/h7,10-11,18,21,24H,2-6,8-9,12-17,19H2,1H3,(H,25,28) | Reactome pathway KEGG
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| Article PubMed
| >5.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Predix Pharmaceuticals Ltd.
Curated by ChEMBL
| Assay Description Binding affinity to human 5HT6 receptor by radioligand binding assay |
J Med Chem 49: 3116-35 (2006)
Article DOI: 10.1021/jm0508641 BindingDB Entry DOI: 10.7270/Q2319VHC |
More data for this Ligand-Target Pair | |
5-hydroxytryptamine receptor 2B
(Homo sapiens (Human)) | BDBM50187377
(CHEMBL209821 | N-(3-(4-(4-(cyclohexylmethylsulfona...)Show SMILES CC(=O)Nc1cccc(c1)N1CCN(CCCCNS(=O)(=O)CC2CCCCC2)CC1 Show InChI InChI=1S/C23H38N4O3S/c1-20(28)25-22-10-7-11-23(18-22)27-16-14-26(15-17-27)13-6-5-12-24-31(29,30)19-21-8-3-2-4-9-21/h7,10-11,18,21,24H,2-6,8-9,12-17,19H2,1H3,(H,25,28) | Reactome pathway KEGG
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CHEMBL PC cid PC sid UniChem
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| Article PubMed
| >5.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Predix Pharmaceuticals Ltd.
Curated by ChEMBL
| Assay Description Binding affinity to 5HT2B receptor by radioligand binding assay |
J Med Chem 49: 3116-35 (2006)
Article DOI: 10.1021/jm0508641 BindingDB Entry DOI: 10.7270/Q2319VHC |
More data for this Ligand-Target Pair | |
5-hydroxytryptamine receptor 1A
(Homo sapiens (Human)) | BDBM50187377
(CHEMBL209821 | N-(3-(4-(4-(cyclohexylmethylsulfona...)Show SMILES CC(=O)Nc1cccc(c1)N1CCN(CCCCNS(=O)(=O)CC2CCCCC2)CC1 Show InChI InChI=1S/C23H38N4O3S/c1-20(28)25-22-10-7-11-23(18-22)27-16-14-26(15-17-27)13-6-5-12-24-31(29,30)19-21-8-3-2-4-9-21/h7,10-11,18,21,24H,2-6,8-9,12-17,19H2,1H3,(H,25,28) | PDB
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| n/a | n/a | n/a | n/a | 20 | n/a | n/a | n/a | n/a |
Predix Pharmaceuticals Ltd.
Curated by ChEMBL
| Assay Description Activity against 5HT1A receptor by Gi-[35S]GTPgammaS binding assay |
J Med Chem 49: 3116-35 (2006)
Article DOI: 10.1021/jm0508641 BindingDB Entry DOI: 10.7270/Q2319VHC |
More data for this Ligand-Target Pair | |
Potassium voltage-gated channel subfamily H member 2
(Homo sapiens (Human)) | BDBM50187377
(CHEMBL209821 | N-(3-(4-(4-(cyclohexylmethylsulfona...)Show SMILES CC(=O)Nc1cccc(c1)N1CCN(CCCCNS(=O)(=O)CC2CCCCC2)CC1 Show InChI InChI=1S/C23H38N4O3S/c1-20(28)25-22-10-7-11-23(18-22)27-16-14-26(15-17-27)13-6-5-12-24-31(29,30)19-21-8-3-2-4-9-21/h7,10-11,18,21,24H,2-6,8-9,12-17,19H2,1H3,(H,25,28) | PDB MMDB
Reactome pathway KEGG
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CHEMBL PC cid PC sid UniChem
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| Article PubMed
| n/a | n/a | 3.80E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Predix Pharmaceuticals Ltd.
Curated by ChEMBL
| Assay Description Inhibition of hERG potassium channel in HEK293 cells by patch clamp assay |
J Med Chem 49: 3116-35 (2006)
Article DOI: 10.1021/jm0508641 BindingDB Entry DOI: 10.7270/Q2319VHC |
More data for this Ligand-Target Pair | |
Potassium voltage-gated channel subfamily H member 2
(Homo sapiens (Human)) | BDBM50187377
(CHEMBL209821 | N-(3-(4-(4-(cyclohexylmethylsulfona...)Show SMILES CC(=O)Nc1cccc(c1)N1CCN(CCCCNS(=O)(=O)CC2CCCCC2)CC1 Show InChI InChI=1S/C23H38N4O3S/c1-20(28)25-22-10-7-11-23(18-22)27-16-14-26(15-17-27)13-6-5-12-24-31(29,30)19-21-8-3-2-4-9-21/h7,10-11,18,21,24H,2-6,8-9,12-17,19H2,1H3,(H,25,28) | PDB MMDB
Reactome pathway KEGG
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CHEMBL PC cid PC sid UniChem
Patents
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| Article PubMed
| n/a | n/a | 3.80E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description Inhibition of human ERG channel |
J Med Chem 52: 4266-76 (2009)
Article DOI: 10.1021/jm900002x BindingDB Entry DOI: 10.7270/Q2MK6DT2 |
More data for this Ligand-Target Pair | |
5-hydroxytryptamine receptor 1A
(Homo sapiens (Human)) | BDBM50187377
(CHEMBL209821 | N-(3-(4-(4-(cyclohexylmethylsulfona...)Show SMILES CC(=O)Nc1cccc(c1)N1CCN(CCCCNS(=O)(=O)CC2CCCCC2)CC1 Show InChI InChI=1S/C23H38N4O3S/c1-20(28)25-22-10-7-11-23(18-22)27-16-14-26(15-17-27)13-6-5-12-24-31(29,30)19-21-8-3-2-4-9-21/h7,10-11,18,21,24H,2-6,8-9,12-17,19H2,1H3,(H,25,28) | PDB
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| n/a | n/a | n/a | n/a | 93 | n/a | n/a | n/a | n/a |
Pierre Fabre Research Center
Curated by ChEMBL
| Assay Description Agonist activity at human 5HT1A receptor expressed in C6 cells assessed as stimulation of [35S]GTPgammaS binding |
J Med Chem 50: 5024-33 (2007)
Article DOI: 10.1021/jm070714l BindingDB Entry DOI: 10.7270/Q2HH6NTB |
More data for this Ligand-Target Pair | |