BindingDB PrimarySearch

BDBM50187381 CHEMBL209324::N-(4-(4-(2-methoxyphenyl)piperazin-1-yl)butyl)-4-methylbenzenesulfonamide

SMILES: COc1ccccc1N1CCN(CCCCNS(=O)(=O)c2ccc(C)cc2)CC1

InChI Key: InChIKey=YMFRPPUSWRHMPF-UHFFFAOYSA-N

Data: 7 KI 2 IC50 1 EC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 10 hits for monomerid = 50187381
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
5-hydroxytryptamine receptor 1A (Homo sapiens (Human))	BDBM50187381 (CHEMBL209324 \| N-(4-(4-(2-methoxyphenyl)piperazin-...) Show SMILES Show InChI	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	1	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Predix Pharmaceuticals Ltd. Curated by ChEMBL					Assay Description Displacement of [3H]8-OH-DPAT from human 5HT1A receptor in HEK293 cells				J Med Chem 49: 3116-35 (2006) Article DOI: 10.1021/jm0508641 BindingDB Entry DOI: 10.7270/Q2319VHC
Predix Pharmaceuticals Ltd. Curated by ChEMBL					More data for this Ligand-Target Pair
Alpha-1 Adrenergic Receptor/ adrenergic receptor/ adrenergic receptor (Rattus norvegicus (rat)-Rattus norvegicus (Rat))	BDBM50187381 (CHEMBL209324 \| N-(4-(4-(2-methoxyphenyl)piperazin-...) Show SMILES Show InChI	Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	6	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Predix Pharmaceuticals Ltd. Curated by ChEMBL					Assay Description Displacement of [3H]prazosin from adrenergic alpha-1 receptor in rat cerebral cortex cells				J Med Chem 49: 3116-35 (2006) Article DOI: 10.1021/jm0508641 BindingDB Entry DOI: 10.7270/Q2319VHC
Predix Pharmaceuticals Ltd. Curated by ChEMBL					More data for this Ligand-Target Pair
Alpha-2A adrenergic receptor (Rattus norvegicus (rat))	BDBM50187381 (CHEMBL209324 \| N-(4-(4-(2-methoxyphenyl)piperazin-...) Show SMILES Show InChI	Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	12	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Predix Pharmaceuticals Ltd. Curated by ChEMBL					Assay Description Displacement of [3H]RX 821002 from Adrenergic alpha-2a receptor in rat cerebral cortex cells				J Med Chem 49: 3116-35 (2006) Article DOI: 10.1021/jm0508641 BindingDB Entry DOI: 10.7270/Q2319VHC
Predix Pharmaceuticals Ltd. Curated by ChEMBL					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 7 (Homo sapiens (Human))	BDBM50187381 (CHEMBL209324 \| N-(4-(4-(2-methoxyphenyl)piperazin-...) Show SMILES Show InChI	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	30	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Predix Pharmaceuticals Ltd. Curated by ChEMBL					Assay Description Binding affinity to 5HT7 receptor by radioligand binding assay				J Med Chem 49: 3116-35 (2006) Article DOI: 10.1021/jm0508641 BindingDB Entry DOI: 10.7270/Q2319VHC
Predix Pharmaceuticals Ltd. Curated by ChEMBL					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 2B (Homo sapiens (Human))	BDBM50187381 (CHEMBL209324 \| N-(4-(4-(2-methoxyphenyl)piperazin-...) Show SMILES Show InChI	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	53	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Predix Pharmaceuticals Ltd. Curated by ChEMBL					Assay Description Binding affinity to 5HT2B receptor by radioligand binding assay				J Med Chem 49: 3116-35 (2006) Article DOI: 10.1021/jm0508641 BindingDB Entry DOI: 10.7270/Q2319VHC
Predix Pharmaceuticals Ltd. Curated by ChEMBL					More data for this Ligand-Target Pair
Sodium-dependent serotonin transporter (Homo sapiens (Human))	BDBM50187381 (CHEMBL209324 \| N-(4-(4-(2-methoxyphenyl)piperazin-...) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	200	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Predix Pharmaceuticals Ltd. Curated by ChEMBL					Assay Description Binding affinity to 5HT transporter by radioligand binding assay				J Med Chem 49: 3116-35 (2006) Article DOI: 10.1021/jm0508641 BindingDB Entry DOI: 10.7270/Q2319VHC
Predix Pharmaceuticals Ltd. Curated by ChEMBL					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 2A (Homo sapiens (Human))	BDBM50187381 (CHEMBL209324 \| N-(4-(4-(2-methoxyphenyl)piperazin-...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	490	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Predix Pharmaceuticals Ltd. Curated by ChEMBL					Assay Description Binding affinity to 5HT2A receptor by radioligand binding assay				J Med Chem 49: 3116-35 (2006) Article DOI: 10.1021/jm0508641 BindingDB Entry DOI: 10.7270/Q2319VHC
Predix Pharmaceuticals Ltd. Curated by ChEMBL					More data for this Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2 (Homo sapiens (Human))	BDBM50187381 (CHEMBL209324 \| N-(4-(4-(2-methoxyphenyl)piperazin-...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>5.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Predix Pharmaceuticals Ltd. Curated by ChEMBL					Assay Description Inhibition of hERG potassium channel in HEK293 cells by patch clamp assay				J Med Chem 49: 3116-35 (2006) Article DOI: 10.1021/jm0508641 BindingDB Entry DOI: 10.7270/Q2319VHC
Predix Pharmaceuticals Ltd. Curated by ChEMBL					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 1A (Homo sapiens (Human))	BDBM50187381 (CHEMBL209324 \| N-(4-(4-(2-methoxyphenyl)piperazin-...) Show SMILES Show InChI	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	21	n/a	n/a	n/a	n/a
Predix Pharmaceuticals Ltd. Curated by ChEMBL					Assay Description Activity against 5HT1A receptor by Gi-[35S]GTPgammaS binding assay				J Med Chem 49: 3116-35 (2006) Article DOI: 10.1021/jm0508641 BindingDB Entry DOI: 10.7270/Q2319VHC
Predix Pharmaceuticals Ltd. Curated by ChEMBL					More data for this Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2 (Homo sapiens (Human))	BDBM50187381 (CHEMBL209324 \| N-(4-(4-(2-methoxyphenyl)piperazin-...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	5.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca Curated by ChEMBL					Assay Description Inhibition of human ERG channel				J Med Chem 52: 4266-76 (2009) Article DOI: 10.1021/jm900002x BindingDB Entry DOI: 10.7270/Q2MK6DT2
AstraZeneca Curated by ChEMBL					More data for this Ligand-Target Pair