BDBM50188000 1-(4-(4-aminoisothiazolo[5,4-d]pyrimidin-3-yl)phenyl)-3-(3-ethylphenyl)urea::CHEMBL445570

SMILES: CCc1cccc(NC(=O)Nc2ccc(cc2)-c2nsc3ncnc(N)c23)c1

InChI Key: InChIKey=YIQCCYWMXOJNTG-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50188000   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM50188000 (1-(4-(4-aminoisothiazolo[5,4-d]pyrimidin-3-yl)phen...) Show SMILES CCc1cccc(NC(=O)Nc2ccc(cc2)-c2nsc3ncnc(N)c23)c1 Show InChI InChI=1S/C20H18N6OS/c1-2-12-4-3-5-15(10-12)25-20(27)24-14-8-6-13(7-9-14)17-16-18(21)22-11-23-19(16)28-26-17/h3-11H,2H2,1H3,(H2,21,22,23)(H2,24,25,27)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	5	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description Inhibition of KDR				Bioorg Med Chem Lett 16: 4326-30 (2006) Article DOI: 10.1016/j.bmcl.2006.05.057 BindingDB Entry DOI: 10.7270/Q2W958S9
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM50188000 (1-(4-(4-aminoisothiazolo[5,4-d]pyrimidin-3-yl)phen...) Show SMILES CCc1cccc(NC(=O)Nc2ccc(cc2)-c2nsc3ncnc(N)c23)c1 Show InChI InChI=1S/C20H18N6OS/c1-2-12-4-3-5-15(10-12)25-20(27)24-14-8-6-13(7-9-14)17-16-18(21)22-11-23-19(16)28-26-17/h3-11H,2H2,1H3,(H2,21,22,23)(H2,24,25,27)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	5	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description Inhibition of KDR by cellular assay				Bioorg Med Chem Lett 16: 4326-30 (2006) Article DOI: 10.1016/j.bmcl.2006.05.057 BindingDB Entry DOI: 10.7270/Q2W958S9
					More data for this Ligand-Target Pair