BDBM50188055 1-(1-phenyl-2-(2-propoxyphenyl)ethyl)piperazine::CHEMBL213754
SMILES: CCCOc1ccccc1CC(N1CCNCC1)c1ccccc1
InChI Key: InChIKey=PSIGDYKJTYBHDY-UHFFFAOYSA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
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Sodium-dependent serotonin transporter (Homo sapiens (Human)) | BDBM50188055 (1-(1-phenyl-2-(2-propoxyphenyl)ethyl)piperazine | ...) | PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 18 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development Curated by ChEMBL | Assay Description Displacement of [3H]citalopram from human SERT expressed in HEK293 cells by scintillation proximity assay | Bioorg Med Chem Lett 20: 3788-92 (2010) Article DOI: 10.1016/j.bmcl.2010.04.052 BindingDB Entry DOI: 10.7270/Q2SN09X4 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium-dependent noradrenaline transporter (Homo sapiens (Human)) | BDBM50188055 (1-(1-phenyl-2-(2-propoxyphenyl)ethyl)piperazine | ...) | Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 31 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development Curated by ChEMBL | Assay Description Displacement of [3H]nisoxetine from human NET expressed in HEK293 cells by scintillation proximity assay | Bioorg Med Chem Lett 20: 3788-92 (2010) Article DOI: 10.1016/j.bmcl.2010.04.052 BindingDB Entry DOI: 10.7270/Q2SN09X4 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium-dependent dopamine transporter (Homo sapiens (Human)) | BDBM50188055 (1-(1-phenyl-2-(2-propoxyphenyl)ethyl)piperazine | ...) | NCI pathway Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 1.95E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development Curated by ChEMBL | Assay Description Displacement of [3H]dopamine from human DAT expressed in HEK293 cells by scintillation proximity assay | Bioorg Med Chem Lett 20: 3788-92 (2010) Article DOI: 10.1016/j.bmcl.2010.04.052 BindingDB Entry DOI: 10.7270/Q2SN09X4 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium-dependent noradrenaline transporter (Homo sapiens (Human)) | BDBM50188055 (1-(1-phenyl-2-(2-propoxyphenyl)ethyl)piperazine | ...) | Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 31 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development Curated by ChEMBL | Assay Description Inhibition of [3H]NA uptake at NA transporter expressed in HEK293 cells | Bioorg Med Chem Lett 16: 4345-8 (2006) Article DOI: 10.1016/j.bmcl.2006.05.051 BindingDB Entry DOI: 10.7270/Q2H99608 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Potassium voltage-gated channel subfamily H member 2 (Homo sapiens (Human)) | BDBM50188055 (1-(1-phenyl-2-(2-propoxyphenyl)ethyl)piperazine | ...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 5.84E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development Curated by ChEMBL | Assay Description Displacement of [3H]dofetilide from human ERG | Bioorg Med Chem Lett 20: 3788-92 (2010) Article DOI: 10.1016/j.bmcl.2010.04.052 BindingDB Entry DOI: 10.7270/Q2SN09X4 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium-dependent serotonin transporter (Homo sapiens (Human)) | BDBM50188055 (1-(1-phenyl-2-(2-propoxyphenyl)ethyl)piperazine | ...) | PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 22 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development Curated by ChEMBL | Assay Description Inhibition of [3H]5-HT uptake at 5HT transporter expressed in HEK293 cells | Bioorg Med Chem Lett 16: 4345-8 (2006) Article DOI: 10.1016/j.bmcl.2006.05.051 BindingDB Entry DOI: 10.7270/Q2H99608 | |||||||||||
More data for this Ligand-Target Pair |