BDBM50188343 4-(2,6-dichloro-phenyl)-8-[4-(2-diethylamino-ethoxy)-phenylamino]-1,2-dihydro-3a,7,9,9b-tetraaza-cyclopenta[a]naphthalen-3-one::CHEMBL379517
SMILES: CCN(CC)CCOc1ccc(Nc2ncc3C=C(N4N(CCC4=O)c3n2)c2c(Cl)cccc2Cl)cc1
InChI Key: InChIKey=TYCSETQHBQUZAZ-UHFFFAOYSA-N
Data: 3 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Tyrosine-protein kinase Lck (Homo sapiens (Human)) | BDBM50188343 (4-(2,6-dichloro-phenyl)-8-[4-(2-diethylamino-ethox...) | PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 2 | n/a | n/a | n/a | n/a | n/a | n/a |
Procter and Gamble Pharmaceuticals Curated by ChEMBL | Assay Description Inhibition of human recombinant Lck in presence of 10 mM ATP | Bioorg Med Chem Lett 16: 4257-61 (2006) Article DOI: 10.1016/j.bmcl.2006.05.072 BindingDB Entry DOI: 10.7270/Q22V2FQD | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Proto-oncogene tyrosine-protein kinase Src (Homo sapiens (Human)) | BDBM50188343 (4-(2,6-dichloro-phenyl)-8-[4-(2-diethylamino-ethox...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 3 | n/a | n/a | n/a | n/a | n/a | n/a |
Procter and Gamble Pharmaceuticals Curated by ChEMBL | Assay Description Inhibition of human recombinant Src in presence of 10 mM ATP | Bioorg Med Chem Lett 16: 4257-61 (2006) Article DOI: 10.1016/j.bmcl.2006.05.072 BindingDB Entry DOI: 10.7270/Q22V2FQD | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tyrosine-protein kinase HCK (Homo sapiens (Human)) | BDBM50188343 (4-(2,6-dichloro-phenyl)-8-[4-(2-diethylamino-ethox...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 48 | n/a | n/a | n/a | n/a | n/a | n/a |
Procter and Gamble Pharmaceuticals Curated by ChEMBL | Assay Description Inhibition of human recombinant Hck in presence of 10 mM ATP | Bioorg Med Chem Lett 16: 4257-61 (2006) Article DOI: 10.1016/j.bmcl.2006.05.072 BindingDB Entry DOI: 10.7270/Q22V2FQD | |||||||||||
More data for this Ligand-Target Pair |