BDBM50188939 1-(2,4-dichlorobenzyl)-3-(5-(2-(methylamino)pyrimidin-4-yl)thiophen-2-yl)urea::CHEMBL376424

SMILES: CNc1nccc(n1)-c1ccc(NC(=O)NCc2ccc(Cl)cc2Cl)s1

InChI Key: InChIKey=BPVVIEDOOWXNGJ-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50188939   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Serine/threonine-protein kinase AKT (Homo sapiens (Human))	BDBM50188939 (1-(2,4-dichlorobenzyl)-3-(5-(2-(methylamino)pyrimi...) Show SMILES CNc1nccc(n1)-c1ccc(NC(=O)NCc2ccc(Cl)cc2Cl)s1 Show InChI InChI=1S/C17H15Cl2N5OS/c1-20-16-21-7-6-13(23-16)14-4-5-15(26-14)24-17(25)22-9-10-2-3-11(18)8-12(10)19/h2-8H,9H2,1H3,(H,20,21,23)(H2,22,24,25)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents	Article PubMed	n/a	n/a	2.10E+3	n/a	n/a	n/a	n/a	n/a	n/a
Chiron Corporation Curated by ChEMBL					Assay Description Inhibition of AKT3 in presence of 0.2 uM ATP				Bioorg Med Chem Lett 16: 4163-8 (2006) Article DOI: 10.1016/j.bmcl.2006.05.092 BindingDB Entry DOI: 10.7270/Q24M945C
					More data for this Ligand-Target Pair