BDBM50188944 CHEMBL211578::N-((S)-3-(2,4-dichlorophenyl)-1-hydroxypropan-2-yl)-5-(2-(methylamino)pyrimidin-4-yl)thiophene-2-carboxamide

SMILES: CNc1nccc(n1)-c1ccc(s1)C(=O)N[C@H](CO)Cc1ccc(Cl)cc1Cl

InChI Key: InChIKey=CKMFFXWNBUATPJ-ZDUSSCGKSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50188944   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Serine/threonine-protein kinase AKT (Homo sapiens (Human))	BDBM50188944 (CHEMBL211578 | N-((S)-3-(2,4-dichlorophenyl)-1-hyd...) Show SMILES CNc1nccc(n1)-c1ccc(s1)C(=O)N[C@H](CO)Cc1ccc(Cl)cc1Cl Show InChI InChI=1S/C19H18Cl2N4O2S/c1-22-19-23-7-6-15(25-19)16-4-5-17(28-16)18(27)24-13(10-26)8-11-2-3-12(20)9-14(11)21/h2-7,9,13,26H,8,10H2,1H3,(H,24,27)(H,22,23,25)/t13-/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	280	n/a	n/a	n/a	n/a	n/a	n/a
Chiron Corporation Curated by ChEMBL					Assay Description Inhibition of AKT3 in presence of 0.2 uM ATP				Bioorg Med Chem Lett 16: 4163-8 (2006) Article DOI: 10.1016/j.bmcl.2006.05.092 BindingDB Entry DOI: 10.7270/Q24M945C
					More data for this Ligand-Target Pair