BDBM50189413 CHEMBL3827774

SMILES: CNC(=O)c1ccc2cncc(-c3ccc4n(C)ncc4c3)c2n1

InChI Key: InChIKey=QDMGVWHKVHTJPB-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50189413   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Cyclin-C (Homo sapiens (Human))	BDBM50189413 (CHEMBL3827774) Show SMILES CNC(=O)c1ccc2cncc(-c3ccc4n(C)ncc4c3)c2n1 Show InChI InChI=1S/C18H15N5O/c1-19-18(24)15-5-3-12-8-20-10-14(17(12)22-15)11-4-6-16-13(7-11)9-21-23(16)2/h3-10H,1-2H3,(H,19,24)	PDB UniProtKB/SwissProt UniProtKB/TrEMBL GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	5.40	n/a	n/a	n/a	n/a	n/a	n/a
The Institute of Cancer Research Curated by ChEMBL					Assay Description Competitive binding affinity to full length His-tagged human recombinant CDK8/cyclin C expressed in baculovirus after 20 mins in presence of Alexa647...				ACS Med Chem Lett 7: 573-8 (2016) BindingDB Entry DOI: 10.7270/Q2N87CRB
					More data for this Ligand-Target Pair
Cyclin-dependent kinase 8 (Homo sapiens (Human))	BDBM50189413 (CHEMBL3827774) Show SMILES CNC(=O)c1ccc2cncc(-c3ccc4n(C)ncc4c3)c2n1 Show InChI InChI=1S/C18H15N5O/c1-19-18(24)15-5-3-12-8-20-10-14(17(12)22-15)11-4-6-16-13(7-11)9-21-23(16)2/h3-10H,1-2H3,(H,19,24)	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	3.40	n/a	n/a	n/a	n/a	n/a	n/a
The Institute of Cancer Research Curated by ChEMBL					Assay Description Binding affinity to CDK8 (unknown origin) expressed in human 7dF3 cells preincubated for 2 hrs followed by beta-oestradiol addition measured after 24...				ACS Med Chem Lett 7: 573-8 (2016) BindingDB Entry DOI: 10.7270/Q2N87CRB
					More data for this Ligand-Target Pair