BDBM50189415 CHEMBL3828637
SMILES: CNC(=O)c1ccc2cncc(-c3ccc4N(C)S(=O)(=O)Cc4c3)c2n1
InChI Key: InChIKey=DFYVDBLGPYTIAT-UHFFFAOYSA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
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Cyclin-dependent kinase 8 (Homo sapiens (Human)) | BDBM50189415 (CHEMBL3828637) | PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid PDB UniChem Similars | PDB PubMed | n/a | n/a | 1.70 | n/a | n/a | n/a | n/a | n/a | n/a |
The Institute of Cancer Research Curated by ChEMBL | Assay Description Binding affinity to CDK8 (unknown origin) expressed in human 7dF3 cells preincubated for 2 hrs followed by beta-oestradiol addition measured after 24... | ACS Med Chem Lett 7: 573-8 (2016) BindingDB Entry DOI: 10.7270/Q2N87CRB | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Cyclin-dependent kinase 8 (Homo sapiens (Human)) | BDBM50189415 (CHEMBL3828637) | PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid PDB UniChem Similars | PDB Article PubMed | n/a | n/a | 0.900 | n/a | n/a | n/a | n/a | n/a | n/a |
University of California Curated by ChEMBL | Assay Description Inhibition of CDK8 (unknown origin) | ACS Med Chem Lett 11: 127-132 (2020) Article DOI: 10.1021/acsmedchemlett.9b00480 | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Cyclin-C (Homo sapiens (Human)) | BDBM50189415 (CHEMBL3828637) | PDB UniProtKB/SwissProt UniProtKB/TrEMBL GoogleScholar AffyNet | CHEMBL PC cid PC sid PDB UniChem Similars | PDB PubMed | n/a | n/a | 0.900 | n/a | n/a | n/a | n/a | n/a | n/a |
The Institute of Cancer Research Curated by ChEMBL | Assay Description Competitive binding affinity to full length His-tagged human recombinant CDK8/cyclin C expressed in baculovirus after 20 mins in presence of Alexa647... | ACS Med Chem Lett 7: 573-8 (2016) BindingDB Entry DOI: 10.7270/Q2N87CRB | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) |