null

SMILES: Cn1cc(cn1)-c1ccc(cc1)-c1cncc2ccc(cc12)S(N)(=O)=O

InChI Key: InChIKey=VGQVYKSVLZIXPH-UHFFFAOYSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50189444   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Cyclin-C (Homo sapiens (Human))	BDBM50189444 (CHEMBL3827333) Show SMILES Cn1cc(cn1)-c1ccc(cc1)-c1cncc2ccc(cc12)S(N)(=O)=O Show InChI InChI=1S/C19H16N4O2S/c1-23-12-16(10-22-23)13-2-4-14(5-3-13)19-11-21-9-15-6-7-17(8-18(15)19)26(20,24)25/h2-12H,1H3,(H2,20,24,25)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	5.60	n/a	n/a	n/a	n/a	n/a	n/a
The Institute of Cancer Research Curated by ChEMBL					Assay Description Competitive binding affinity to full length His-tagged human recombinant CDK8/cyclin C expressed in baculovirus after 20 mins in presence of Alexa647...				ACS Med Chem Lett 7: 573-8 (2016) Article DOI: 10.1021/acsmedchemlett.6b00022 BindingDB Entry DOI: 10.7270/Q2N87CRB
					More data for this Ligand-Target Pair
Cyclin-dependent kinase 8 (Homo sapiens (Human))	BDBM50189444 (CHEMBL3827333) Show SMILES Cn1cc(cn1)-c1ccc(cc1)-c1cncc2ccc(cc12)S(N)(=O)=O Show InChI InChI=1S/C19H16N4O2S/c1-23-12-16(10-22-23)13-2-4-14(5-3-13)19-11-21-9-15-6-7-17(8-18(15)19)26(20,24)25/h2-12H,1H3,(H2,20,24,25)	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	43	n/a	n/a	n/a	n/a	n/a	n/a
The Institute of Cancer Research Curated by ChEMBL					Assay Description Binding affinity to CDK8 (unknown origin) expressed in human 7dF3 cells preincubated for 2 hrs followed by beta-oestradiol addition measured after 24...				ACS Med Chem Lett 7: 573-8 (2016) Article DOI: 10.1021/acsmedchemlett.6b00022 BindingDB Entry DOI: 10.7270/Q2N87CRB
					More data for this Ligand-Target Pair