BDBM50189450 CHEMBL3828071

SMILES: Cn1cc(cn1)-c1ccc(cc1)-c1cnc(N)c2ccc(nc12)C(=O)N1CC(F)(F)C1

InChI Key: InChIKey=QBMVSTFFMINBKY-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50189450   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Cyclin-C (Homo sapiens (Human))	BDBM50189450 (CHEMBL3828071) Show SMILES Cn1cc(cn1)-c1ccc(cc1)-c1cnc(N)c2ccc(nc12)C(=O)N1CC(F)(F)C1 Show InChI InChI=1S/C22H18F2N6O/c1-29-10-15(8-27-29)13-2-4-14(5-3-13)17-9-26-20(25)16-6-7-18(28-19(16)17)21(31)30-11-22(23,24)12-30/h2-10H,11-12H2,1H3,(H2,25,26)	PDB UniProtKB/SwissProt UniProtKB/TrEMBL GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	17	n/a	n/a	n/a	n/a	n/a	n/a
The Institute of Cancer Research Curated by ChEMBL					Assay Description Competitive binding affinity to full length His-tagged human recombinant CDK8/cyclin C expressed in baculovirus after 20 mins in presence of Alexa647...				ACS Med Chem Lett 7: 573-8 (2016) BindingDB Entry DOI: 10.7270/Q2N87CRB
					More data for this Ligand-Target Pair
Cyclin-dependent kinase 8 (Homo sapiens (Human))	BDBM50189450 (CHEMBL3828071) Show SMILES Cn1cc(cn1)-c1ccc(cc1)-c1cnc(N)c2ccc(nc12)C(=O)N1CC(F)(F)C1 Show InChI InChI=1S/C22H18F2N6O/c1-29-10-15(8-27-29)13-2-4-14(5-3-13)17-9-26-20(25)16-6-7-18(28-19(16)17)21(31)30-11-22(23,24)12-30/h2-10H,11-12H2,1H3,(H2,25,26)	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	5.80	n/a	n/a	n/a	n/a	n/a	n/a
The Institute of Cancer Research Curated by ChEMBL					Assay Description Binding affinity to CDK8 (unknown origin) expressed in human 7dF3 cells preincubated for 2 hrs followed by beta-oestradiol addition measured after 24...				ACS Med Chem Lett 7: 573-8 (2016) BindingDB Entry DOI: 10.7270/Q2N87CRB
					More data for this Ligand-Target Pair