BDBM50189572 3-(4-bromo-phenyl)-5-methylene-7-aza-tricyclo[5.3.0.0*4,8*]decane::CHEMBL212452
SMILES: Brc1ccc(cc1)C1CC2CCC3C1C(=C)CN23
InChI Key: InChIKey=KVHKGSIWONIENO-UHFFFAOYSA-N
Data: 3 KI
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Sodium-dependent serotonin transporter (Homo sapiens (Human)) | BDBM50189572 (3-(4-bromo-phenyl)-5-methylene-7-aza-tricyclo[5.3....) | PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 0.280 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Emory University Curated by ChEMBL | Assay Description Displacement of [3H]citalopram from human SERT transfected in HEK293 cells | Bioorg Med Chem Lett 16: 4661-3 (2006) Article DOI: 10.1016/j.bmcl.2006.05.098 BindingDB Entry DOI: 10.7270/Q22R3R93 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium-dependent noradrenaline transporter (Homo sapiens (Human)) | BDBM50189572 (3-(4-bromo-phenyl)-5-methylene-7-aza-tricyclo[5.3....) | Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 2.94 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Emory University Curated by ChEMBL | Assay Description Displacement of [3H]nisoxetine from human NET transfected in HEK293 cells | Bioorg Med Chem Lett 16: 4661-3 (2006) Article DOI: 10.1016/j.bmcl.2006.05.098 BindingDB Entry DOI: 10.7270/Q22R3R93 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium-dependent dopamine transporter (Homo sapiens (Human)) | BDBM50189572 (3-(4-bromo-phenyl)-5-methylene-7-aza-tricyclo[5.3....) | NCI pathway Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 41.9 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Emory University Curated by ChEMBL | Assay Description Displacement of [125I]RTI-55 from human DAT transfected in HEK293 cells | Bioorg Med Chem Lett 16: 4661-3 (2006) Article DOI: 10.1016/j.bmcl.2006.05.098 BindingDB Entry DOI: 10.7270/Q22R3R93 | |||||||||||
More data for this Ligand-Target Pair |