BDBM50189602 2,4-difluoro-N-methyl-5-((2-(pyridin-2-ylamino)thiazol-5-ylmethyl)amino)benzamide::CHEMBL212267

SMILES: CNC(=O)c1cc(NCc2cnc(Nc3ccccn3)s2)c(F)cc1F

InChI Key: InChIKey=JIMHRVUJVAYWAR-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50189602   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM50189602 (2,4-difluoro-N-methyl-5-((2-(pyridin-2-ylamino)thi...) Show SMILES CNC(=O)c1cc(NCc2cnc(Nc3ccccn3)s2)c(F)cc1F Show InChI InChI=1S/C17H15F2N5OS/c1-20-16(25)11-6-14(13(19)7-12(11)18)22-8-10-9-23-17(26-10)24-15-4-2-3-5-21-15/h2-7,9,22H,8H2,1H3,(H,20,25)(H,21,23,24)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	71	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Pharmaceutical Research Institute Curated by ChEMBL					Assay Description Inhibition of FLK1				J Med Chem 49: 3766-9 (2006) Article DOI: 10.1021/jm060347y BindingDB Entry DOI: 10.7270/Q2PG1RBM
					More data for this Ligand-Target Pair