BDBM50189867 CHEMBL3828649

SMILES: CNc1ccc2[nH]c(nc2c1)-c1n[nH]c2ccc(OC(C)c3c(Cl)cncc3Cl)cc12

InChI Key: InChIKey=AZMWGZVPAMERHK-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50189867   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Fibroblast growth factor receptor 1 (Homo sapiens (Human))	BDBM50189867 (CHEMBL3828649) Show SMILES CNc1ccc2[nH]c(nc2c1)-c1n[nH]c2ccc(OC(C)c3c(Cl)cncc3Cl)cc12 Show InChI InChI=1S/C22H18Cl2N6O/c1-11(20-15(23)9-26-10-16(20)24)31-13-4-6-17-14(8-13)21(30-29-17)22-27-18-5-3-12(25-2)7-19(18)28-22/h3-11,25H,1-2H3,(H,27,28)(H,29,30)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents	PubMed	n/a	n/a	2.10	n/a	n/a	n/a	n/a	n/a	n/a
East China University of Science& Technology Curated by ChEMBL					Assay Description Inhibition of recombinant human FGFR1 using poly (Glu, Tyr) 4:1 as substrate after 60 mins by ELISA				J Med Chem 59: 6690-708 (2016) BindingDB Entry DOI: 10.7270/Q2474CT3
					More data for this Ligand-Target Pair