BDBM50189871 CHEMBL3827594

SMILES: CC(Oc1ccc2[nH]nc(-c3nc4cc(ccc4[nH]3)N3CCCN(C)CC3)c2c1)c1c(Cl)cncc1Cl

InChI Key: InChIKey=JQKDGGRZIBHFLB-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50189871   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Fibroblast growth factor receptor 1 (Homo sapiens (Human))	BDBM50189871 (CHEMBL3827594) Show SMILES CC(Oc1ccc2[nH]nc(-c3nc4cc(ccc4[nH]3)N3CCCN(C)CC3)c2c1)c1c(Cl)cncc1Cl Show InChI InChI=1S/C27H27Cl2N7O/c1-16(25-20(28)14-30-15-21(25)29)37-18-5-7-22-19(13-18)26(34-33-22)27-31-23-6-4-17(12-24(23)32-27)36-9-3-8-35(2)10-11-36/h4-7,12-16H,3,8-11H2,1-2H3,(H,31,32)(H,33,34)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	7.60	n/a	n/a	n/a	n/a	n/a	n/a
East China University of Science& Technology Curated by ChEMBL					Assay Description Inhibition of recombinant human FGFR1 using poly (Glu, Tyr) 4:1 as substrate after 60 mins by ELISA				J Med Chem 59: 6690-708 (2016) BindingDB Entry DOI: 10.7270/Q2474CT3
					More data for this Ligand-Target Pair