BDBM50189874 CHEMBL3828022

SMILES: C[C@H](Oc1ccc2[nH]nc(-c3nc4cc(ccc4[nH]3)N3CCN(C)CC3)c2c1)c1c(Cl)cncc1Cl

InChI Key: InChIKey=BAWZESLJEVSFRN-HNNXBMFYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50189874   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Fibroblast growth factor receptor 1 (Homo sapiens (Human))	BDBM50189874 (CHEMBL3828022) Show SMILES C[C@H](Oc1ccc2[nH]nc(-c3nc4cc(ccc4[nH]3)N3CCN(C)CC3)c2c1)c1c(Cl)cncc1Cl |r| Show InChI InChI=1S/C26H25Cl2N7O/c1-15(24-19(27)13-29-14-20(24)28)36-17-4-6-21-18(12-17)25(33-32-21)26-30-22-5-3-16(11-23(22)31-26)35-9-7-34(2)8-10-35/h3-6,11-15H,7-10H2,1-2H3,(H,30,31)(H,32,33)/t15-/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	9.40	n/a	n/a	n/a	n/a	n/a	n/a
East China University of Science& Technology Curated by ChEMBL					Assay Description Inhibition of recombinant human FGFR1 using poly (Glu, Tyr) 4:1 as substrate after 60 mins by ELISA				J Med Chem 59: 6690-708 (2016) BindingDB Entry DOI: 10.7270/Q2474CT3
					More data for this Ligand-Target Pair