BDBM50190226 CHEMBL379874::thiophene-2-carboxylic acid [8-chloro-11-(4-methyl-piperazin-1-yl)-dibenzo[b,e][1,4]diazepin-5-yl]-amide

SMILES: CN1CCN(CC1)C1=Nc2cc(Cl)ccc2N(NC(=O)c2cccs2)c2ccccc12

InChI Key: InChIKey=FLKZGKHMMRPRAS-UHFFFAOYSA-N

Data: 2 KI

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50190226   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
D(1A) dopamine receptor (Homo sapiens (Human))	BDBM50190226 (CHEMBL379874 | thiophene-2-carboxylic acid [8-chlo...) Show SMILES CN1CCN(CC1)C1=Nc2cc(Cl)ccc2N(NC(=O)c2cccs2)c2ccccc12 |t:8| Show InChI InChI=1S/C23H22ClN5OS/c1-27-10-12-28(13-11-27)22-17-5-2-3-6-19(17)29(26-23(30)21-7-4-14-31-21)20-9-8-16(24)15-18(20)25-22/h2-9,14-15H,10-13H2,1H3,(H,26,30)	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	14	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Schering-Plough Research Institute Curated by ChEMBL					Assay Description Displacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cells				Bioorg Med Chem Lett 16: 4543-7 (2006) Article DOI: 10.1016/j.bmcl.2006.06.022 BindingDB Entry DOI: 10.7270/Q2GT5MSW
					More data for this Ligand-Target Pair
D(2) dopamine receptor (Homo sapiens (Human))	BDBM50190226 (CHEMBL379874 | thiophene-2-carboxylic acid [8-chlo...) Show SMILES CN1CCN(CC1)C1=Nc2cc(Cl)ccc2N(NC(=O)c2cccs2)c2ccccc12 |t:8| Show InChI InChI=1S/C23H22ClN5OS/c1-27-10-12-28(13-11-27)22-17-5-2-3-6-19(17)29(26-23(30)21-7-4-14-31-21)20-9-8-16(24)15-18(20)25-22/h2-9,14-15H,10-13H2,1H3,(H,26,30)	PDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	1.47E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Schering-Plough Research Institute Curated by ChEMBL					Assay Description Displacement of [3H]methylspiperone from human dopamine D2 receptor expressed in CHO cells				Bioorg Med Chem Lett 16: 4543-7 (2006) Article DOI: 10.1016/j.bmcl.2006.06.022 BindingDB Entry DOI: 10.7270/Q2GT5MSW
					More data for this Ligand-Target Pair