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Enter Data

BDBM50190568 1-(6-(tritylamino)hexyl)pyrimidine-2,4(1H,3H)-dione::1-(6-tritylaminohexyl)uracil::CHEMBL211120

SMILES: O=c1ccn(CCCCCCNC(c2ccccc2)(c2ccccc2)c2ccccc2)c(=O)[nH]1

InChI Key: InChIKey=VSXSPOQXSWUNCD-UHFFFAOYSA-N

Data: 5 KI

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50190568
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
dUTP pyrophosphatase (Plasmodium falciparum)	BDBM50190568 (1-(6-(tritylamino)hexyl)pyrimidine-2,4(1H,3H)-dion...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	1.80E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Wales Cardiff Curated by ChEMBL					Assay Description Inhibition of Plasmodium falciparum dUTPase				Eur J Med Chem 44: 678-88 (2009) Article DOI: 10.1016/j.ejmech.2008.05.018 BindingDB Entry DOI: 10.7270/Q20K28CG
University of Wales Cardiff Curated by ChEMBL					More data for this Ligand-Target Pair
dUTP pyrophosphatase (Plasmodium falciparum)	BDBM50190568 (1-(6-(tritylamino)hexyl)pyrimidine-2,4(1H,3H)-dion...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	1.80E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Cardiff University Curated by ChEMBL					Assay Description Inhibition of Plasmodium falciparum dUTPase				J Med Chem 49: 4183-95 (2006) Article DOI: 10.1021/jm060126s BindingDB Entry DOI: 10.7270/Q22J6BF0
Cardiff University Curated by ChEMBL					More data for this Ligand-Target Pair
Deoxyuridine 5'-triphosphate nucleotidohydrolase (dUTPase) (Homo sapiens (Human))	BDBM50190568 (1-(6-(tritylamino)hexyl)pyrimidine-2,4(1H,3H)-dion...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	>1.00E+6	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Instituto de Parasitolog£a y Biomedicina L£pez-Neyra Curated by ChEMBL					Assay Description Inhibition of human dUTPase using dUTP as substrate by spectrophotometric analysis				Eur J Med Chem 46: 3309-14 (2011) Article DOI: 10.1016/j.ejmech.2011.04.052 BindingDB Entry DOI: 10.7270/Q27S7Q1H
					More data for this Ligand-Target Pair
Deoxyuridine 5'-triphosphate nucleotidohydrolase (dUTPase) (Homo sapiens (Human))	BDBM50190568 (1-(6-(tritylamino)hexyl)pyrimidine-2,4(1H,3H)-dion...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	>1.00E+6	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Cardiff University Curated by ChEMBL					Assay Description Inhibition of human recombinant dUTPase				J Med Chem 49: 4183-95 (2006) Article DOI: 10.1021/jm060126s BindingDB Entry DOI: 10.7270/Q22J6BF0
Cardiff University Curated by ChEMBL					More data for this Ligand-Target Pair
Deoxyuridine 5'-triphosphate nucleotidohydrolase (dUTPase) (Homo sapiens (Human))	BDBM50190568 (1-(6-(tritylamino)hexyl)pyrimidine-2,4(1H,3H)-dion...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	>1.00E+6	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Wales Cardiff Curated by ChEMBL					Assay Description Inhibition of human dUTPase				Eur J Med Chem 44: 678-88 (2009) Article DOI: 10.1016/j.ejmech.2008.05.018 BindingDB Entry DOI: 10.7270/Q20K28CG
University of Wales Cardiff Curated by ChEMBL					More data for this Ligand-Target Pair