Found 12 hits for monomerid = 50190746 Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Neprilysin
(Rattus norvegicus (Rat)) | BDBM50190746
((R)-2-((1-((5-ethyl-1,3,4-thiadiazol-2-yl)carbamoy...)Show SMILES CCC[C@H](CC1(CCCC1)C(=O)Nc1nnc(CC)s1)C(O)=O Show InChI InChI=1S/C16H25N3O3S/c1-3-7-11(13(20)21)10-16(8-5-6-9-16)14(22)17-15-19-18-12(4-2)23-15/h11H,3-10H2,1-2H3,(H,20,21)(H,17,19,22)/t11-/m1/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet
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CHEMBL MCE PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 14.3 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development
Curated by ChEMBL
| Assay Description Inhibition of rat NEP |
J Med Chem 49: 4409-24 (2006)
Article DOI: 10.1021/jm060133g BindingDB Entry DOI: 10.7270/Q2930SS8 |
More data for this Ligand-Target Pair | |
Neprilysin
(Homo sapiens (Human)) | BDBM50190746
((R)-2-((1-((5-ethyl-1,3,4-thiadiazol-2-yl)carbamoy...)Show SMILES CCC[C@H](CC1(CCCC1)C(=O)Nc1nnc(CC)s1)C(O)=O Show InChI InChI=1S/C16H25N3O3S/c1-3-7-11(13(20)21)10-16(8-5-6-9-16)14(22)17-15-19-18-12(4-2)23-15/h11H,3-10H2,1-2H3,(H,20,21)(H,17,19,22)/t11-/m1/s1 | PDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
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CHEMBL MCE PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 26 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development
Curated by ChEMBL
| Assay Description Inhibition of dog NEP |
J Med Chem 49: 4409-24 (2006)
Article DOI: 10.1021/jm060133g BindingDB Entry DOI: 10.7270/Q2930SS8 |
More data for this Ligand-Target Pair | |
Neprilysin
(Oryctolagus cuniculus (rabbit)) | BDBM50190746
((R)-2-((1-((5-ethyl-1,3,4-thiadiazol-2-yl)carbamoy...)Show SMILES CCC[C@H](CC1(CCCC1)C(=O)Nc1nnc(CC)s1)C(O)=O Show InChI InChI=1S/C16H25N3O3S/c1-3-7-11(13(20)21)10-16(8-5-6-9-16)14(22)17-15-19-18-12(4-2)23-15/h11H,3-10H2,1-2H3,(H,20,21)(H,17,19,22)/t11-/m1/s1 | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet
| Purchase
CHEMBL MCE PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 10.2 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development
Curated by ChEMBL
| Assay Description Inhibition of rabbit NEP |
J Med Chem 49: 4409-24 (2006)
Article DOI: 10.1021/jm060133g BindingDB Entry DOI: 10.7270/Q2930SS8 |
More data for this Ligand-Target Pair | |
Neprilysin
(Homo sapiens (Human)) | BDBM50190746
((R)-2-((1-((5-ethyl-1,3,4-thiadiazol-2-yl)carbamoy...)Show SMILES CCC[C@H](CC1(CCCC1)C(=O)Nc1nnc(CC)s1)C(O)=O Show InChI InChI=1S/C16H25N3O3S/c1-3-7-11(13(20)21)10-16(8-5-6-9-16)14(22)17-15-19-18-12(4-2)23-15/h11H,3-10H2,1-2H3,(H,20,21)(H,17,19,22)/t11-/m1/s1 | PDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL MCE PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 18.9 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development
Curated by ChEMBL
| Assay Description Inhibition of human NEP |
J Med Chem 49: 4409-24 (2006)
Article DOI: 10.1021/jm060133g BindingDB Entry DOI: 10.7270/Q2930SS8 |
More data for this Ligand-Target Pair | |
Acetylcholinesterase
(Homo sapiens (Human)) | BDBM50190746
((R)-2-((1-((5-ethyl-1,3,4-thiadiazol-2-yl)carbamoy...)Show SMILES CCC[C@H](CC1(CCCC1)C(=O)Nc1nnc(CC)s1)C(O)=O Show InChI InChI=1S/C16H25N3O3S/c1-3-7-11(13(20)21)10-16(8-5-6-9-16)14(22)17-15-19-18-12(4-2)23-15/h11H,3-10H2,1-2H3,(H,20,21)(H,17,19,22)/t11-/m1/s1 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL MCE PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | >3.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development
Curated by ChEMBL
| Assay Description Inhibition of dog ACE |
J Med Chem 49: 4409-24 (2006)
Article DOI: 10.1021/jm060133g BindingDB Entry DOI: 10.7270/Q2930SS8 |
More data for this Ligand-Target Pair | |
Neprilysin
(Homo sapiens (Human)) | BDBM50190746
((R)-2-((1-((5-ethyl-1,3,4-thiadiazol-2-yl)carbamoy...)Show SMILES CCC[C@H](CC1(CCCC1)C(=O)Nc1nnc(CC)s1)C(O)=O Show InChI InChI=1S/C16H25N3O3S/c1-3-7-11(13(20)21)10-16(8-5-6-9-16)14(22)17-15-19-18-12(4-2)23-15/h11H,3-10H2,1-2H3,(H,20,21)(H,17,19,22)/t11-/m1/s1 | PDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL MCE PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 18.9 | n/a | n/a | n/a | n/a | 7.0 | n/a |
Pfizer Global Research and Development
Curated by ChEMBL
| Assay Description Inhibition of human kidney NEP at pH 7 |
Bioorg Med Chem 15: 142-59 (2006)
Article DOI: 10.1016/j.bmc.2006.10.002 BindingDB Entry DOI: 10.7270/Q2ZS2W4J |
More data for this Ligand-Target Pair | |
Neprilysin
(Homo sapiens (Human)) | BDBM50190746
((R)-2-((1-((5-ethyl-1,3,4-thiadiazol-2-yl)carbamoy...)Show SMILES CCC[C@H](CC1(CCCC1)C(=O)Nc1nnc(CC)s1)C(O)=O Show InChI InChI=1S/C16H25N3O3S/c1-3-7-11(13(20)21)10-16(8-5-6-9-16)14(22)17-15-19-18-12(4-2)23-15/h11H,3-10H2,1-2H3,(H,20,21)(H,17,19,22)/t11-/m1/s1 | PDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL MCE PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 19.7 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development
Curated by ChEMBL
| Assay Description Inhibition of human recombinant NEP |
J Med Chem 49: 4409-24 (2006)
Article DOI: 10.1021/jm060133g BindingDB Entry DOI: 10.7270/Q2930SS8 |
More data for this Ligand-Target Pair | |
Neprilysin
(Oryctolagus cuniculus (rabbit)) | BDBM50190746
((R)-2-((1-((5-ethyl-1,3,4-thiadiazol-2-yl)carbamoy...)Show SMILES CCC[C@H](CC1(CCCC1)C(=O)Nc1nnc(CC)s1)C(O)=O Show InChI InChI=1S/C16H25N3O3S/c1-3-7-11(13(20)21)10-16(8-5-6-9-16)14(22)17-15-19-18-12(4-2)23-15/h11H,3-10H2,1-2H3,(H,20,21)(H,17,19,22)/t11-/m1/s1 | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet
| Purchase
CHEMBL MCE PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 10.2 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development
Curated by ChEMBL
| Assay Description Inhibition of rabbit NEP |
Bioorg Med Chem 15: 142-59 (2006)
Article DOI: 10.1016/j.bmc.2006.10.002 BindingDB Entry DOI: 10.7270/Q2ZS2W4J |
More data for this Ligand-Target Pair | |
Neprilysin
(Homo sapiens (Human)) | BDBM50190746
((R)-2-((1-((5-ethyl-1,3,4-thiadiazol-2-yl)carbamoy...)Show SMILES CCC[C@H](CC1(CCCC1)C(=O)Nc1nnc(CC)s1)C(O)=O Show InChI InChI=1S/C16H25N3O3S/c1-3-7-11(13(20)21)10-16(8-5-6-9-16)14(22)17-15-19-18-12(4-2)23-15/h11H,3-10H2,1-2H3,(H,20,21)(H,17,19,22)/t11-/m1/s1 | PDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL MCE PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 19.7 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development
Curated by ChEMBL
| Assay Description Inhibition of human recombinant NEP |
Bioorg Med Chem 15: 142-59 (2006)
Article DOI: 10.1016/j.bmc.2006.10.002 BindingDB Entry DOI: 10.7270/Q2ZS2W4J |
More data for this Ligand-Target Pair | |
Neprilysin
(Homo sapiens (Human)) | BDBM50190746
((R)-2-((1-((5-ethyl-1,3,4-thiadiazol-2-yl)carbamoy...)Show SMILES CCC[C@H](CC1(CCCC1)C(=O)Nc1nnc(CC)s1)C(O)=O Show InChI InChI=1S/C16H25N3O3S/c1-3-7-11(13(20)21)10-16(8-5-6-9-16)14(22)17-15-19-18-12(4-2)23-15/h11H,3-10H2,1-2H3,(H,20,21)(H,17,19,22)/t11-/m1/s1 | PDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL MCE PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 31.8 | n/a | n/a | n/a | n/a | 7.4 | n/a |
Pfizer Global Research and Development
Curated by ChEMBL
| Assay Description Inhibition of human kidney NEP at pH 7.4 |
Bioorg Med Chem 15: 142-59 (2006)
Article DOI: 10.1016/j.bmc.2006.10.002 BindingDB Entry DOI: 10.7270/Q2ZS2W4J |
More data for this Ligand-Target Pair | |
Neprilysin
(Rattus norvegicus (Rat)) | BDBM50190746
((R)-2-((1-((5-ethyl-1,3,4-thiadiazol-2-yl)carbamoy...)Show SMILES CCC[C@H](CC1(CCCC1)C(=O)Nc1nnc(CC)s1)C(O)=O Show InChI InChI=1S/C16H25N3O3S/c1-3-7-11(13(20)21)10-16(8-5-6-9-16)14(22)17-15-19-18-12(4-2)23-15/h11H,3-10H2,1-2H3,(H,20,21)(H,17,19,22)/t11-/m1/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet
| Purchase
CHEMBL MCE PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 14.3 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development
Curated by ChEMBL
| Assay Description Inhibition of rat NEP |
Bioorg Med Chem 15: 142-59 (2006)
Article DOI: 10.1016/j.bmc.2006.10.002 BindingDB Entry DOI: 10.7270/Q2ZS2W4J |
More data for this Ligand-Target Pair | |
Endothelin-converting enzyme 1
(Homo sapiens (Human)) | BDBM50190746
((R)-2-((1-((5-ethyl-1,3,4-thiadiazol-2-yl)carbamoy...)Show SMILES CCC[C@H](CC1(CCCC1)C(=O)Nc1nnc(CC)s1)C(O)=O Show InChI InChI=1S/C16H25N3O3S/c1-3-7-11(13(20)21)10-16(8-5-6-9-16)14(22)17-15-19-18-12(4-2)23-15/h11H,3-10H2,1-2H3,(H,20,21)(H,17,19,22)/t11-/m1/s1 | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL MCE PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | >3.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development
Curated by ChEMBL
| Assay Description Inhibition of human ECE1 |
J Med Chem 49: 4409-24 (2006)
Article DOI: 10.1021/jm060133g BindingDB Entry DOI: 10.7270/Q2930SS8 |
More data for this Ligand-Target Pair | |