BDBM50191280 5,21-Dibromo-4-hydroxy-2-oxa-10,14-diaza-tricyclo[16.2.2.1*3,7*]tricosa-1(21),3,5,7(23),18(22),19-hexaene-11,15-dione::5,21-dibromo-4-hydroxy-2-oxa-10,14-diaza-tricyclo[16.2.2.10,0]-tricosa-1(21),3(23),4,6,18(22),19-hexaene-11,15-dione::CHEMBL213853
SMILES: Oc1c(Br)cc2CCNC(=O)CCNC(=O)CCc3ccc(Oc1c2)c(Br)c3
InChI Key: InChIKey=KAVCIWPHSSAORZ-UHFFFAOYSA-N
Data: 1 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Ryanodine receptor 1 (Homo sapiens (Human)) | BDBM50191280 (5,21-Dibromo-4-hydroxy-2-oxa-10,14-diaza-tricyclo[...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 6.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Polish Academy of Sciences Curated by ChEMBL | Assay Description Binding affinity to RYR1 channels by calcium mobilization assay | Bioorg Med Chem Lett 18: 5734-7 (2009) Article DOI: 10.1016/j.bmcl.2008.09.080 BindingDB Entry DOI: 10.7270/Q2NV9K5T | |||||||||||
More data for this Ligand-Target Pair |