BindingDB PrimarySearch

BDBM50191405 (2'Z,3'E)-7-bromoindirubin-3'-oxime::CHEMBL373834

SMILES: Oc1[nH]c2c(Br)cccc2c1-c1[nH]c2ccccc2c1N=O

InChI Key: InChIKey=HYMACPDEJIEMST-UHFFFAOYSA-N

Data: 12 IC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 12 hits for monomerid = 50191405
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Glycogen synthase kinase-3 (Sus scrofa)	BDBM50191405 ((2'Z,3'E)-7-bromoindirubin-3'-oxime \| CHEMBL373834) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
University of Athens Curated by ChEMBL					Assay Description Inhibition of porcine brain GSK3beta using YRRAAVPPSPSLSRHSSPHQSpEDEEE as substrate				ACS Med Chem Lett 4: 22-26 (2013) Article DOI: 10.1021/ml300207a BindingDB Entry DOI: 10.7270/Q2Q81FD1
University of Athens Curated by ChEMBL					More data for this Ligand-Target Pair
Dual-specificity tyrosine-phosphorylation regulated kinase 2 (Homo sapiens (Human))	BDBM50191405 ((2'Z,3'E)-7-bromoindirubin-3'-oxime \| CHEMBL373834) Show SMILES Show InChI	PDB MMDB NCI pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.30E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Athens Curated by ChEMBL					Assay Description Inhibition of human recombinant GST-fused DYRK2 expressed in Escherichia coli using KKISGRLSPIMTEQ as substrate after 30 mins by scintillation counti...				ACS Med Chem Lett 4: 22-26 (2013) Article DOI: 10.1021/ml300207a BindingDB Entry DOI: 10.7270/Q2Q81FD1
University of Athens Curated by ChEMBL					More data for this Ligand-Target Pair
Cyclin-dependent-like kinase 5 (Homo sapiens (Human))	BDBM50191405 ((2'Z,3'E)-7-bromoindirubin-3'-oxime \| CHEMBL373834) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
University of Athens Curated by ChEMBL					Assay Description Inhibition of human recombinant CDK5				ACS Med Chem Lett 4: 22-26 (2013) Article DOI: 10.1021/ml300207a BindingDB Entry DOI: 10.7270/Q2Q81FD1
University of Athens Curated by ChEMBL					More data for this Ligand-Target Pair
Casein kinase I isoform alpha (Sus scrofa)	BDBM50191405 ((2'Z,3'E)-7-bromoindirubin-3'-oxime \| CHEMBL373834) Show SMILES Show InChI	UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
University of Athens Curated by ChEMBL					Assay Description Inhibition of porcine brain CK1 using RRKHAAIGpSAYSITA as substrate				ACS Med Chem Lett 4: 22-26 (2013) Article DOI: 10.1021/ml300207a BindingDB Entry DOI: 10.7270/Q2Q81FD1
University of Athens Curated by ChEMBL					More data for this Ligand-Target Pair
Dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A (RAT)	BDBM50191405 ((2'Z,3'E)-7-bromoindirubin-3'-oxime \| CHEMBL373834) Show SMILES Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.90E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Athens Curated by ChEMBL					Assay Description Inhibition of rat recombinant GST-fused DYRK1A expressed in Escherichia coli using KKISGRLSPIMTEQ as substrate after 30 mins by scintillation countin...				ACS Med Chem Lett 4: 22-26 (2013) Article DOI: 10.1021/ml300207a BindingDB Entry DOI: 10.7270/Q2Q81FD1
University of Athens Curated by ChEMBL					More data for this Ligand-Target Pair
Aryl hydrocarbon receptor (Homo sapiens (Human))	BDBM50191405 ((2'Z,3'E)-7-bromoindirubin-3'-oxime \| CHEMBL373834) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
C.N.R.S. Curated by ChEMBL					Assay Description Survival of mouse AhR +/+ 5L cells after 48 hrs by MTS reduction assay				J Med Chem 49: 4638-49 (2006) Article DOI: 10.1021/jm060314i BindingDB Entry DOI: 10.7270/Q21G0N3Z
C.N.R.S. Curated by ChEMBL					More data for this Ligand-Target Pair
Serine/threonine-protein kinase Aurora-C (Homo sapiens (Human))	BDBM50191405 ((2'Z,3'E)-7-bromoindirubin-3'-oxime \| CHEMBL373834) Show SMILES Show InChI	PDB NCI pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	700	n/a	n/a	n/a	n/a	n/a	n/a
University of Athens Curated by ChEMBL					Assay Description Inhibition of human recombinant aurora C kinase				J Med Chem 50: 4027-37 (2007) Article DOI: 10.1021/jm070077z BindingDB Entry DOI: 10.7270/Q2PC323X
University of Athens Curated by ChEMBL					More data for this Ligand-Target Pair
Aurora kinase A (Homo sapiens (Human))	BDBM50191405 ((2'Z,3'E)-7-bromoindirubin-3'-oxime \| CHEMBL373834) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
University of Athens Curated by ChEMBL					Assay Description Inhibition of human recombinant aurora A kinase				J Med Chem 50: 4027-37 (2007) Article DOI: 10.1021/jm070077z BindingDB Entry DOI: 10.7270/Q2PC323X
University of Athens Curated by ChEMBL					More data for this Ligand-Target Pair
Cyclin-dependent-like kinase 5 (Homo sapiens (Human))	BDBM50191405 ((2'Z,3'E)-7-bromoindirubin-3'-oxime \| CHEMBL373834) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3.30E+4	n/a	n/a	n/a	n/a	n/a	n/a
University of Athens Curated by ChEMBL					Assay Description Inhibition of CDK5				J Nat Prod 72: 2199-202 (2009) Article DOI: 10.1021/np9003905 BindingDB Entry DOI: 10.7270/Q2QZ2B31
University of Athens Curated by ChEMBL					More data for this Ligand-Target Pair
Cyclin-dependent kinase 1 (Homo sapiens (Human))	BDBM50191405 ((2'Z,3'E)-7-bromoindirubin-3'-oxime \| CHEMBL373834) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.20E+4	n/a	n/a	n/a	n/a	n/a	n/a
University of Athens Curated by ChEMBL					Assay Description Inhibition of CDK1				J Nat Prod 72: 2199-202 (2009) Article DOI: 10.1021/np9003905 BindingDB Entry DOI: 10.7270/Q2QZ2B31
University of Athens Curated by ChEMBL					More data for this Ligand-Target Pair
Cyclin-Dependent Kinase 5 (CDK5) (Homo sapiens (Human))	BDBM50191405 ((2'Z,3'E)-7-bromoindirubin-3'-oxime \| CHEMBL373834) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3.30E+4	n/a	n/a	n/a	n/a	n/a	n/a
C.N.R.S. Curated by ChEMBL					Assay Description Inhibition of mammalian CDK5/p25				J Med Chem 49: 4638-49 (2006) Article DOI: 10.1021/jm060314i BindingDB Entry DOI: 10.7270/Q21G0N3Z
C.N.R.S. Curated by ChEMBL					More data for this Ligand-Target Pair
Aurora kinase B (Homo sapiens (Human))	BDBM50191405 ((2'Z,3'E)-7-bromoindirubin-3'-oxime \| CHEMBL373834) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	4.60E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Athens Curated by ChEMBL					Assay Description Inhibition of human recombinant aurora B kinase				J Med Chem 50: 4027-37 (2007) Article DOI: 10.1021/jm070077z BindingDB Entry DOI: 10.7270/Q2PC323X
University of Athens Curated by ChEMBL					More data for this Ligand-Target Pair