BDBM50191469 CHEMBL3895703

SMILES: CNc1n[nH]c2ccc(cc12)C(=O)N1CCC[C@H]1c1ccc(Cl)cc1

InChI Key: InChIKey=CUQBBHUITNFLKO-KRWDZBQOSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50191469   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Cyclin-C (Homo sapiens (Human))	BDBM50191469 (CHEMBL3895703) Show SMILES CNc1n[nH]c2ccc(cc12)C(=O)N1CCC[C@H]1c1ccc(Cl)cc1 |r| Show InChI InChI=1S/C19H19ClN4O/c1-21-18-15-11-13(6-9-16(15)22-23-18)19(25)24-10-2-3-17(24)12-4-7-14(20)8-5-12/h4-9,11,17H,2-3,10H2,1H3,(H2,21,22,23)/t17-/m0/s1	PDB UniProtKB/SwissProt UniProtKB/TrEMBL GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	5.40	n/a	n/a	n/a	n/a	n/a	n/a
Merck KGaA Curated by ChEMBL					Assay Description Inhibition of Alexa647 tracer binding to full length recombinant human His-tagged CDK8/cyclin C expressed in Baculovirus expression system preincubat...				J Med Chem 59: 9337-9349 (2016) BindingDB Entry DOI: 10.7270/Q2K64M1C
					More data for this Ligand-Target Pair
Cyclin-dependent kinase 8 (Homo sapiens (Human))	BDBM50191469 (CHEMBL3895703) Show SMILES CNc1n[nH]c2ccc(cc12)C(=O)N1CCC[C@H]1c1ccc(Cl)cc1 |r| Show InChI InChI=1S/C19H19ClN4O/c1-21-18-15-11-13(6-9-16(15)22-23-18)19(25)24-10-2-3-17(24)12-4-7-14(20)8-5-12/h4-9,11,17H,2-3,10H2,1H3,(H2,21,22,23)/t17-/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	12	n/a	n/a	n/a	n/a	n/a	n/a
Merck KGaA Curated by ChEMBL					Assay Description Inhibition of CDK8 in human 7dF3 cells preincubated for 2 hrs followed by beta-oestradiol addition measured after 24 hrs by luciferase reporter gene ...				J Med Chem 59: 9337-9349 (2016) BindingDB Entry DOI: 10.7270/Q2K64M1C
					More data for this Ligand-Target Pair