BindingDB PrimarySearch

BDBM50191854 CHEMBL436774::N-(1-acetyl-piperidin-4-yl)-N'-(adamantan-1-yl)urea::N-(1-acetylpiperidin-4-yl)-N'-(adamant-1-yl)urea

SMILES: CC(=O)N1CCC(CC1)NC(=O)NC12CC3CC(CC(C3)C1)C2

InChI Key: InChIKey=HUDQLWBKJOMXSZ-UHFFFAOYSA-N

Data: 10 IC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 12 hits for monomerid = 50191854
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
EBifunctional epoxide hydrolase 2 (Homo sapiens (Human))	BDBM50191854 (CHEMBL436774 \| N-(1-acetyl-piperidin-4-yl)-N'-(ada...) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars		20	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
TBA					More data for this Ligand-Target Pair
Soluble epoxide hydrolase (sEH) (Mus musculus (Mouse))	BDBM50191854 (CHEMBL436774 \| N-(1-acetyl-piperidin-4-yl)-N'-(ada...) Show SMILES Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	3	n/a	n/a	n/a	n/a	n/a	n/a
Ar£te Therapeutics, Inc. Curated by ChEMBL					Assay Description Inhibition of mouse soluble epoxide hydrolase				Bioorg Med Chem Lett 21: 983-8 (2011) Article DOI: 10.1016/j.bmcl.2010.12.042 BindingDB Entry DOI: 10.7270/Q20865KB
Ar£te Therapeutics, Inc. Curated by ChEMBL					More data for this Ligand-Target Pair
EBifunctional epoxide hydrolase 2 (Homo sapiens (Human))	BDBM50191854 (CHEMBL436774 \| N-(1-acetyl-piperidin-4-yl)-N'-(ada...) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	8	n/a	n/a	n/a	n/a	n/a	n/a
Ar£te Therapeutics, Inc. Curated by ChEMBL					Assay Description Inhibition of human soluble epoxide hydrolase				Bioorg Med Chem Lett 21: 983-8 (2011) Article DOI: 10.1016/j.bmcl.2010.12.042 BindingDB Entry DOI: 10.7270/Q20865KB
Ar£te Therapeutics, Inc. Curated by ChEMBL					More data for this Ligand-Target Pair
EBifunctional epoxide hydrolase 2 (Homo sapiens (Human))	BDBM50191854 (CHEMBL436774 \| N-(1-acetyl-piperidin-4-yl)-N'-(ada...) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	57	n/a	n/a	n/a	n/a	n/a	n/a
Ar£te Therapeutics, Inc. Curated by ChEMBL					Assay Description Inhibition of soluble epoxide hydrolase in HUVEC assessed inhibition of as conversion of 14, 15-EET to 14, 15-DHET				Bioorg Med Chem Lett 21: 983-8 (2011) Article DOI: 10.1016/j.bmcl.2010.12.042 BindingDB Entry DOI: 10.7270/Q20865KB
Ar£te Therapeutics, Inc. Curated by ChEMBL					More data for this Ligand-Target Pair
EBifunctional epoxide hydrolase 2 (Homo sapiens (Human))	BDBM50191854 (CHEMBL436774 \| N-(1-acetyl-piperidin-4-yl)-N'-(ada...) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	7	n/a	n/a	n/a	n/a	n/a	n/a
Columbia University Curated by ChEMBL					Assay Description Inhibition of human soluble epoxide hydrolase using CMNPC as substrate after 5 mins by fluorescent assay				Bioorg Med Chem Lett 22: 601-5 (2011) Article DOI: 10.1016/j.bmcl.2011.10.074 BindingDB Entry DOI: 10.7270/Q2TM7BJ7
Columbia University Curated by ChEMBL					More data for this Ligand-Target Pair
EBifunctional epoxide hydrolase 2 (Homo sapiens (Human))	BDBM50191854 (CHEMBL436774 \| N-(1-acetyl-piperidin-4-yl)-N'-(ada...) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars		n/a	n/a	8	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
TBA					More data for this Ligand-Target Pair
EBifunctional epoxide hydrolase 2 (Homo sapiens (Human))	BDBM50191854 (CHEMBL436774 \| N-(1-acetyl-piperidin-4-yl)-N'-(ada...) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	15	n/a	n/a	n/a	n/a	n/a	n/a
University of California-Davis Curated by ChEMBL					Assay Description Inhibition of human sEH by fluorescent assay				J Med Chem 50: 3825-40 (2007) Article DOI: 10.1021/jm070270t BindingDB Entry DOI: 10.7270/Q2TQ62BW
University of California-Davis Curated by ChEMBL					More data for this Ligand-Target Pair
Soluble epoxide hydrolase (sEH) (Mus musculus (Mouse))	BDBM50191854 (CHEMBL436774 \| N-(1-acetyl-piperidin-4-yl)-N'-(ada...) Show SMILES Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	9	n/a	n/a	n/a	n/a	n/a	n/a
University of California-Davis Curated by ChEMBL					Assay Description Inhibition of mouse recombinant soluble epoxide hydrolase by fluorescent assay				J Med Chem 50: 3825-40 (2007) Article DOI: 10.1021/jm070270t BindingDB Entry DOI: 10.7270/Q2TQ62BW
University of California-Davis Curated by ChEMBL					More data for this Ligand-Target Pair
EBifunctional epoxide hydrolase 2 (Homo sapiens (Human))	BDBM50191854 (CHEMBL436774 \| N-(1-acetyl-piperidin-4-yl)-N'-(ada...) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	8	n/a	n/a	n/a	n/a	n/a	n/a
Universitat de Barcelona Curated by ChEMBL					Assay Description Inhibition of recombinant human liver soluble epoxide hydrolase expressed in baculovirus infected Sf21 cells using NEPC as substrate by fluorescence ...				Bioorg Med Chem 27: (2019) Article DOI: 10.1016/j.bmc.2019.115078
Universitat de Barcelona Curated by ChEMBL					More data for this Ligand-Target Pair
Epoxide hydratase (Mus musculus (Mouse))	BDBM50191854 (CHEMBL436774 \| N-(1-acetyl-piperidin-4-yl)-N'-(ada...) Show SMILES Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	3	n/a	n/a	n/a	n/a	n/a	n/a
Universitat de Barcelona Curated by ChEMBL					Assay Description Inhibition of murine soluble epoxide hydrolase expressed in baculovirus infected Sf21 cells using NEPC as substrate by fluorescence based assay				Bioorg Med Chem 27: (2019) Article DOI: 10.1016/j.bmc.2019.115078
Universitat de Barcelona Curated by ChEMBL					More data for this Ligand-Target Pair
EBifunctional epoxide hydrolase 2 (Homo sapiens (Human))	BDBM50191854 (CHEMBL436774 \| N-(1-acetyl-piperidin-4-yl)-N'-(ada...) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	7	n/a	n/a	n/a	n/a	n/a	n/a
University of California Curated by ChEMBL					Assay Description Inhibition of soluble epoxide hydroxylase by kinetic fluorescent assay				Bioorg Med Chem Lett 16: 5212-6 (2006) Article DOI: 10.1016/j.bmcl.2006.07.009 BindingDB Entry DOI: 10.7270/Q29023DS
University of California Curated by ChEMBL					More data for this Ligand-Target Pair
Epoxide hydrolase 2 (Rattus norvegicus)	BDBM50191854 (CHEMBL436774 \| N-(1-acetyl-piperidin-4-yl)-N'-(ada...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	6	n/a	n/a	n/a	n/a	n/a	n/a
University of California-Davis Curated by ChEMBL					Assay Description Inhibition of rat recombinant soluble epoxide hydrolase by fluorescent assay				J Med Chem 50: 3825-40 (2007) Article DOI: 10.1021/jm070270t BindingDB Entry DOI: 10.7270/Q2TQ62BW
University of California-Davis Curated by ChEMBL					More data for this Ligand-Target Pair