BDBM50191925 4-(1H-pyrrolo[2,3-b]pyridin-3-yl)-N-o-tolylpyrimidin-2-amine::CHEMBL212491

SMILES: Cc1ccccc1Nc1nccc(n1)-c1c[nH]c2ncccc12

InChI Key: InChIKey=XDAVVOMFBOEFCG-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50191925   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Proto-oncogene tyrosine-protein kinase receptor Ret (Homo sapiens (Human))	BDBM50191925 (4-(1H-pyrrolo[2,3-b]pyridin-3-yl)-N-o-tolylpyrimid...) Show SMILES Cc1ccccc1Nc1nccc(n1)-c1c[nH]c2ncccc12 Show InChI InChI=1S/C18H15N5/c1-12-5-2-3-7-15(12)22-18-20-10-8-16(23-18)14-11-21-17-13(14)6-4-9-19-17/h2-11H,1H3,(H,19,21)(H,20,22,23)	PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
National Tsing Hua University Curated by ChEMBL					Assay Description Inhibition of RET kinase				Bioorg Med Chem Lett 21: 4490-7 (2011) Article DOI: 10.1016/j.bmcl.2011.06.003 BindingDB Entry DOI: 10.7270/Q2BV7H06
					More data for this Ligand-Target Pair
Cyclin B/Cyclin-Dependent Kinase 1 (CDK1)/G2/mitotic-specific cyclin B2/G2/mitotic-specific cyclin B3 (Homo sapiens (Human))	BDBM50191925 (4-(1H-pyrrolo[2,3-b]pyridin-3-yl)-N-o-tolylpyrimid...) Show SMILES Cc1ccccc1Nc1nccc(n1)-c1c[nH]c2ncccc12 Show InChI InChI=1S/C18H15N5/c1-12-5-2-3-7-15(12)22-18-20-10-8-16(23-18)14-11-21-17-13(14)6-4-9-19-17/h2-11H,1H3,(H,19,21)(H,20,22,23)	PDB UniProtKB/SwissProt antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	3	n/a	n/a	n/a	n/a	n/a	n/a
Johnson & Johnson Pharmaceutical Research & Development Curated by ChEMBL					Assay Description Inhibition of CDK1/cyclinB by Flashplate assay				Bioorg Med Chem Lett 16: 4818-21 (2006) Article DOI: 10.1016/j.bmcl.2006.06.073 BindingDB Entry DOI: 10.7270/Q2571BNM
					More data for this Ligand-Target Pair