BDBM50191943 CHEMBL3910291

SMILES: Cc1cccc(c1)-c1cc2c3n(cnc3cnc2cn1)-c1ccc2nc[nH]c2c1

InChI Key: InChIKey=RMBNGICVQYNHSG-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50191943   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Mitogen-activated protein kinase kinase kinase 8 (Homo sapiens (Human))	BDBM50191943 (CHEMBL3910291) Show SMILES Cc1cccc(c1)-c1cc2c3n(cnc3cnc2cn1)-c1ccc2nc[nH]c2c1 Show InChI InChI=1S/C23H16N6/c1-14-3-2-4-15(7-14)19-9-17-21(10-24-19)25-11-22-23(17)29(13-28-22)16-5-6-18-20(8-16)27-12-26-18/h2-13H,1H3,(H,26,27)	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	200	n/a	n/a	n/a	n/a	n/a	n/a
Novartis Institutes for BioMedical Research Curated by ChEMBL					Assay Description Inhibition of human COT (66 to 395 residues) expressed in Sf21 cells using 5-Fluo-Ahx-AGAGSGQLIDSNleANSFVGTR-NH2 as substrate after 60 mins by calipe...				J Med Chem 59: 7544-60 (2016) BindingDB Entry DOI: 10.7270/Q29P33MR
					More data for this Ligand-Target Pair