BDBM50192145 CHEMBL383945::methyl 1-(4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl)-2-phenylpiperidine-2-carboxylate

SMILES: COC(=O)C1(CCCCN1c1ccc(cc1)C(O)(C(F)(F)F)C(F)(F)F)c1ccccc1

InChI Key: InChIKey=HFFCHXHRFPTTEV-UHFFFAOYSA-N

Data: 2 IC50  2 EC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50192145   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Oxysterols receptor LXR-beta (Homo sapiens (Human))	BDBM50192145 (CHEMBL383945 | methyl 1-(4-(1,1,1,3,3,3-hexafluoro...) Show SMILES COC(=O)C1(CCCCN1c1ccc(cc1)C(O)(C(F)(F)F)C(F)(F)F)c1ccccc1 Show InChI InChI=1S/C22H21F6NO3/c1-32-18(30)19(15-7-3-2-4-8-15)13-5-6-14-29(19)17-11-9-16(10-12-17)20(31,21(23,24)25)22(26,27)28/h2-4,7-12,31H,5-6,13-14H2,1H3	UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	30	n/a	n/a	n/a	n/a	n/a	n/a
F. Hoffmann-La Roche Ltd. Curated by ChEMBL					Assay Description Binding affinity to LXRbeta by radioligand displacement assay				Bioorg Med Chem Lett 16: 5231-7 (2006) Article DOI: 10.1016/j.bmcl.2006.06.081 BindingDB Entry DOI: 10.7270/Q2HD7V80
					More data for this Ligand-Target Pair
Oxysterols receptor LXR-alpha (Homo sapiens (Human))	BDBM50192145 (CHEMBL383945 | methyl 1-(4-(1,1,1,3,3,3-hexafluoro...) Show SMILES COC(=O)C1(CCCCN1c1ccc(cc1)C(O)(C(F)(F)F)C(F)(F)F)c1ccccc1 Show InChI InChI=1S/C22H21F6NO3/c1-32-18(30)19(15-7-3-2-4-8-15)13-5-6-14-29(19)17-11-9-16(10-12-17)20(31,21(23,24)25)22(26,27)28/h2-4,7-12,31H,5-6,13-14H2,1H3	UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	90	n/a	n/a	n/a	n/a
F. Hoffmann-La Roche Ltd. Curated by ChEMBL					Assay Description Transactivation of LXRalpha by luciferase reporter gene assay				Bioorg Med Chem Lett 16: 5231-7 (2006) Article DOI: 10.1016/j.bmcl.2006.06.081 BindingDB Entry DOI: 10.7270/Q2HD7V80
					More data for this Ligand-Target Pair
Oxysterols receptor LXR-beta (Homo sapiens (Human))	BDBM50192145 (CHEMBL383945 | methyl 1-(4-(1,1,1,3,3,3-hexafluoro...) Show SMILES COC(=O)C1(CCCCN1c1ccc(cc1)C(O)(C(F)(F)F)C(F)(F)F)c1ccccc1 Show InChI InChI=1S/C22H21F6NO3/c1-32-18(30)19(15-7-3-2-4-8-15)13-5-6-14-29(19)17-11-9-16(10-12-17)20(31,21(23,24)25)22(26,27)28/h2-4,7-12,31H,5-6,13-14H2,1H3	UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	40	n/a	n/a	n/a	n/a
F. Hoffmann-La Roche Ltd. Curated by ChEMBL					Assay Description Transactivation of LXRbeta by luciferase reporter gene assay				Bioorg Med Chem Lett 16: 5231-7 (2006) Article DOI: 10.1016/j.bmcl.2006.06.081 BindingDB Entry DOI: 10.7270/Q2HD7V80
					More data for this Ligand-Target Pair
Oxysterols receptor LXR-alpha (Homo sapiens (Human))	BDBM50192145 (CHEMBL383945 | methyl 1-(4-(1,1,1,3,3,3-hexafluoro...) Show SMILES COC(=O)C1(CCCCN1c1ccc(cc1)C(O)(C(F)(F)F)C(F)(F)F)c1ccccc1 Show InChI InChI=1S/C22H21F6NO3/c1-32-18(30)19(15-7-3-2-4-8-15)13-5-6-14-29(19)17-11-9-16(10-12-17)20(31,21(23,24)25)22(26,27)28/h2-4,7-12,31H,5-6,13-14H2,1H3	UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	60	n/a	n/a	n/a	n/a	n/a	n/a
F. Hoffmann-La Roche Ltd. Curated by ChEMBL					Assay Description Binding affinity to LXRalpha by radioligand displacement assay				Bioorg Med Chem Lett 16: 5231-7 (2006) Article DOI: 10.1016/j.bmcl.2006.06.081 BindingDB Entry DOI: 10.7270/Q2HD7V80
					More data for this Ligand-Target Pair