BDBM50192294 1-[(5R,6R,8R,9R)-4-amino-9-(tert-butyl-dimethyl-silanyloxy)-6-(tert-butyl-dimethyl-silanyloxymethyl)-3-(3-hydroxy-propenyl)-2,2-dioxo-1,7-dioxa-2lambda*6*-thia-spiro[4.4]non-3-en-8-yl]-5-methyl-1H-pyrimidine-2,4-dione::CHEMBL379255

SMILES: Cc1cn([C@@H]2O[C@H](CO[Si](C)(C)C(C)(C)C)[C@@]3(OS(=O)(=O)C(=CCCO)C3=N)[C@H]2O[Si](C)(C)C(C)(C)C)c(=O)[nH]c1=O

InChI Key: InChIKey=PPSMYMVWZXRNAT-ZOZFQSSASA-N

Data: 2 IC50  2 EC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50192294   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Human immunodeficiency virus type 1 reverse transcriptase (Human immunodeficiency virus 1)	BDBM50192294 (1-[(5R,6R,8R,9R)-4-amino-9-(tert-butyl-dimethyl-si...) Show SMILES Cc1cn([C@@H]2O[C@H](CO[Si](C)(C)C(C)(C)C)[C@@]3(OS(=O)(=O)C(=CCCO)C3=N)[C@H]2O[Si](C)(C)C(C)(C)C)c(=O)[nH]c1=O |w:22.22| Show InChI InChI=1S/C27H47N3O9SSi2/c1-17-15-30(24(33)29-22(17)32)23-21(38-42(10,11)26(5,6)7)27(19(37-23)16-36-41(8,9)25(2,3)4)20(28)18(13-12-14-31)40(34,35)39-27/h13,15,19,21,23,28,31H,12,14,16H2,1-11H3,(H,29,32,33)/t19-,21+,23-,27+/m1/s1	PDB MMDB UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.60E+4	n/a	n/a	n/a	n/a	n/a	n/a
University of Pittsburgh School of Medicine Curated by ChEMBL					Assay Description Inhibition of FLAG-p66/HIS-p51-mediated HIV1 reverse transcriptase dimerization				J Med Chem 49: 4834-41 (2006) Article DOI: 10.1021/jm0604575 BindingDB Entry DOI: 10.7270/Q2GH9HKC
					More data for this Ligand-Target Pair
Human immunodeficiency virus type 1 reverse transcriptase (Human immunodeficiency virus 1)	BDBM50192294 (1-[(5R,6R,8R,9R)-4-amino-9-(tert-butyl-dimethyl-si...) Show SMILES Cc1cn([C@@H]2O[C@H](CO[Si](C)(C)C(C)(C)C)[C@@]3(OS(=O)(=O)C(=CCCO)C3=N)[C@H]2O[Si](C)(C)C(C)(C)C)c(=O)[nH]c1=O |w:22.22| Show InChI InChI=1S/C27H47N3O9SSi2/c1-17-15-30(24(33)29-22(17)32)23-21(38-42(10,11)26(5,6)7)27(19(37-23)16-36-41(8,9)25(2,3)4)20(28)18(13-12-14-31)40(34,35)39-27/h13,15,19,21,23,28,31H,12,14,16H2,1-11H3,(H,29,32,33)/t19-,21+,23-,27+/m1/s1	PDB MMDB UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	n/a	n/a	>2.00E+3	n/a	n/a	n/a	n/a
Instituto de Qu£mica M£dica (C.S.I.C.) Curated by ChEMBL					Assay Description Effective concentration required to inhibit HIV-1 induced cytopathicity in CEM cell culture by 50%.				J Med Chem 45: 3934-45 (2002) BindingDB Entry DOI: 10.7270/Q2639QXQ
					More data for this Ligand-Target Pair
Human immunodeficiency virus type 1 reverse transcriptase (Human immunodeficiency virus 1)	BDBM50192294 (1-[(5R,6R,8R,9R)-4-amino-9-(tert-butyl-dimethyl-si...) Show SMILES Cc1cn([C@@H]2O[C@H](CO[Si](C)(C)C(C)(C)C)[C@@]3(OS(=O)(=O)C(=CCCO)C3=N)[C@H]2O[Si](C)(C)C(C)(C)C)c(=O)[nH]c1=O |w:22.22| Show InChI InChI=1S/C27H47N3O9SSi2/c1-17-15-30(24(33)29-22(17)32)23-21(38-42(10,11)26(5,6)7)27(19(37-23)16-36-41(8,9)25(2,3)4)20(28)18(13-12-14-31)40(34,35)39-27/h13,15,19,21,23,28,31H,12,14,16H2,1-11H3,(H,29,32,33)/t19-,21+,23-,27+/m1/s1	PDB MMDB UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	n/a	n/a	6.60E+3	n/a	n/a	n/a	n/a
Instituto de Qu£mica M£dica (C.S.I.C.) Curated by ChEMBL					Assay Description Effective concentration required to inhibit HIV-1 induced cytopathicity in MT-4 cell culture by 50%.				J Med Chem 45: 3934-45 (2002) BindingDB Entry DOI: 10.7270/Q2639QXQ
					More data for this Ligand-Target Pair
Human immunodeficiency virus type 1 reverse transcriptase (Human immunodeficiency virus 1)	BDBM50192294 (1-[(5R,6R,8R,9R)-4-amino-9-(tert-butyl-dimethyl-si...) Show SMILES Cc1cn([C@@H]2O[C@H](CO[Si](C)(C)C(C)(C)C)[C@@]3(OS(=O)(=O)C(=CCCO)C3=N)[C@H]2O[Si](C)(C)C(C)(C)C)c(=O)[nH]c1=O |w:22.22| Show InChI InChI=1S/C27H47N3O9SSi2/c1-17-15-30(24(33)29-22(17)32)23-21(38-42(10,11)26(5,6)7)27(19(37-23)16-36-41(8,9)25(2,3)4)20(28)18(13-12-14-31)40(34,35)39-27/h13,15,19,21,23,28,31H,12,14,16H2,1-11H3,(H,29,32,33)/t19-,21+,23-,27+/m1/s1	PDB MMDB UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	4.80E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Pittsburgh School of Medicine Curated by ChEMBL					Assay Description Inhibition of HIV1 reverse transcriptase RNA-dependent DNA polymerase activity				J Med Chem 49: 4834-41 (2006) Article DOI: 10.1021/jm0604575 BindingDB Entry DOI: 10.7270/Q2GH9HKC
					More data for this Ligand-Target Pair